| Gene Symbol | TGF |
| Full Name | β Receptor 1 (TGFBR1) Protein |
| Function | TGF-β Receptor 1 (TGFBR1) is a transmembrane serine/threonine kinase that serves as the primary type I receptor for transforming growth factor-beta ligands in the nervous system. |
| Molecular Weight | ~56 kDa |
| Amino Acids | 503 amino acids |
| Pathways | unfolded protein response, TGF-beta signaling, neurotrophin signaling, NF-kB signaling, oxidative stress response |
| GeneCards | TGF |
| Human Protein Atlas | TGF |
| cysteine-rich domain (CR) | Mediates ligand binding and receptor oligomerization |
| Glycine-serine (GS) rich region | Flexible linker connecting extracellular and transmembrane domains |
| Activation loop | Contains key serine residues (Ser465, Ser467) phosphorylated by type II receptor |
| GS domain | Region containing multiple glycine-serine repeats that regulates kinase activity |
| Substrate binding pocket | Recognizes SMAD2/3 proteins |
| Associated Diseases | ALS, Alzheimer, Alzheimer's disease, cancer, cardiovascular disease, glioblastoma |
| Known Drugs/Compounds | curcumin, rapamycin |
| Interactions | ADAMTS4, AKT, AMPK, ANGPT1, APP, AQP1 |
| KG Connections | 251 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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