concept

MKI67

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MKI67: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

83Connections

0Hypotheses

0Analyses

45Outgoing

38Incoming

0Experiments

0Debates

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💡 Concept Info

Name	MKI67
Key Genes/Proteins	AKT, AKT1, AMPK, APC, ATG, AURKB
Related Diseases	Alzheimer's disease, cancer
Related Pathways	autophagy pathway

Pathway Diagram

graph TD
    MKI67[MKI67]
    MKI67 -.biomarker for.-> High_Grade_Serous_Ovarian_Canc[High-Grade Serous Ovarian Cancer]
    MKI67 -->|activates| MTOR[MTOR]
    MKI67 -->|activates| PI3K[PI3K]
    MKI67 -->|activates| PIK3CA[PIK3CA]
    MKI67 -->|activates| PSMA1[PSMA1]
    MKI67 -->|activates| PSMB5[PSMB5]
    MKI67 -->|activates| RPS6KB1[RPS6KB1]
    MKI67 -->|activates| SQSTM1[SQSTM1]
    MKI67 -->|activates| TP53[TP53]
    MKI67 -->|activates| MYC[MYC]
    AKT[AKT] -->|activates| MKI67
    CDKN1A[CDKN1A] -->|activates| MKI67
    CDKN2A[CDKN2A] -->|activates| MKI67
    EIF4EBP1[EIF4EBP1] -->|activates| MKI67
    GLB1[GLB1] -->|activates| MKI67
    LC3[LC3] -->|activates| MKI67
    APC[APC] -->|activates| MKI67
    AXIN2[AXIN2] -->|activates| MKI67
    BECN1[BECN1] -->|activates| MKI67
    CTNNB1[CTNNB1] -->|activates| MKI67

Outgoing (45)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:MKI67	data_in	dataset_row	0.00
High-Grade Serous Ovarian Cancer	biomarker_for	disease	0.85
RNA	activates	gene	0.60
MMP1	activates	gene	0.60
MMP9	activates	gene	0.60
NFKB1	targets	gene	0.60
NLRP3	targets	gene	0.60
TLR4	targets	gene	0.60
PI3K-AKT-mTOR signaling	participates_in	pathway	0.60
MTOR	activates	gene	0.60
PI3K	activates	gene	0.60
PIK3CA	activates	gene	0.60
PSMA1	activates	gene	0.60
PSMB5	activates	gene	0.60
RPS6KB1	activates	gene	0.60
SQSTM1	activates	gene	0.60
ROS	activates	gene	0.60
TP53	activates	gene	0.60
PCNA	activates	gene	0.60
SMAD	activates	gene	0.60
TGFB	activates	gene	0.60
Alzheimer's disease	activates	disease	0.60
Parkinson's disease	activates	disease	0.60
autophagy pathway	participates_in	pathway	0.60
oxidative stress response	participates_in	pathway	0.60
senescence	participates_in	pathway	0.60
ubiquitin-proteasome	participates_in	pathway	0.60
TGF-beta signaling	participates_in	pathway	0.60
RAS	activates	gene	0.60
TSPAN1	activates	gene	0.60
WNT	activates	gene	0.60
Wnt signaling	participates_in	pathway	0.60
NF-kB signaling	participates_in	pathway	0.60
PLK1	activates	gene	0.60
MYC	activates	gene	0.60
RAB7A	activates	gene	0.60
TCF4	activates	gene	0.60
cancer	activates	disease	0.60
NEFH	associated_with	gene	0.60
NEFL	associated_with	gene	0.60
PVALB	associated_with	gene	0.60
SST	associated_with	gene	0.60
TPR	associated_with	gene	0.60
PVALB	interacts_with	gene	0.60
SST	interacts_with	gene	0.60

Incoming (38)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:MKI67	data_in	dataset_row	0.00
APC	activates	gene	0.60
AXIN2	activates	gene	0.60
BECN1	activates	gene	0.60
CTNNB1	activates	gene	0.60
GAPDH	activates	gene	0.60
GSK3B	activates	gene	0.60
LAMP1	activates	gene	0.60
ATG	activates	gene	0.60
DMSO	activates	gene	0.60
MAP1LC3	activates	gene	0.60
rapamycin	targets	drug	0.60
AMPK	activates	gene	0.60
CCND1	activates	gene	0.60
CSNK1A1	activates	gene	0.60
FAM83A	activates	gene	0.60
GFP	activates	gene	0.60
MIR454	activates	gene	0.60
CDK1	activates	gene	0.60
AKT	activates	gene	0.60
CDKN1A	activates	gene	0.60
CDKN2A	activates	gene	0.60
EIF4EBP1	activates	gene	0.60
GLB1	activates	gene	0.60
LC3	activates	gene	0.60
AKT1	targets	gene	0.60
CASP1	targets	gene	0.60
IL1B	targets	gene	0.60
BUB1	activates	gene	0.60
AURKB	associated_with	gene	0.60
CALM1	associated_with	gene	0.60
CDC42	associated_with	gene	0.60
GAP43	associated_with	gene	0.60
KIF15	associated_with	gene	0.60
KIF5B	associated_with	gene	0.60
AURKB	interacts_with	gene	0.60
CALM1	interacts_with	gene	0.60
KIF5B	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning MKI67 in their description or question text

No additional research found