gene

SMAD2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SMAD2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

260Connections

1Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

SMAD2 is a gene implicated in neurodegeneration research. Key relationships include: activates, regulates, therapeutic target. Associated with Aging, Als, Autoimmune. Connected to 153 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	SMAD2
Full Name	SMAD Family Member 2
Chromosome	18q21.1
Function	is an important component in the neurobiology of neurodegenerative diseases.
Subcellular Localization	(cytoplasmic vs. nuclear) is dynamically regulated by TGF-beta signaling[@schilling2008]
Amino Acids	467 aa
Pathways	TGF-β, TGF-β signaling, TGF-β Signaling
UniProt ID	Q99716
NCBI Gene ID	4092
Ensembl ID	ENSG00000175387
OMIM	601023
GeneCards	SMAD2
Human Protein Atlas	SMAD2
MH1 domain (N-terminal)	Contains the DNA-binding domain that recognizes SMAD-binding elements (SBE) in target gene promoters
MH2 domain (C-terminal)	Mediates protein-protein interactions with receptors, co-SMADs, and transcriptional regulators
Associated Diseases	Aging, Als, Alzheimer, Cancer, Colorectal Cancer, Tumor
Known Drugs/Compounds	APIGENIN, lycopene
Interactions	AKT, ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, APOPTOSIS, APP
KG Connections	259 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: SMAD2 — AlphaFold Q99716 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

SMAD2 Gene

gene · 890 words

→

SMAD2 Protein

protein · 732 words

→

Pathway Diagram

graph TD
    SMAD2["SMAD2"] -->|"regulates"| mitophagy["mitophagy"]
    SMAD2["SMAD2"] -->|"activates"| Inflammation["Inflammation"]
    SMAD2["SMAD2"] -->|"expressed in"| Fibrosis["Fibrosis"]
    SMAD2["SMAD2"] -->|"activates"| Als["Als"]
    SMAD2["SMAD2"] -->|"activates"| Ms["Ms"]
    SMAD2["SMAD2"] -->|"therapeutic target"| Multiple_Sclerosis["Multiple Sclerosis"]
    lycopene["lycopene"] -.->|"inhibits"| SMAD2["SMAD2"]
    SQSTM1["SQSTM1"] -->|"expressed in"| SMAD2["SMAD2"]
    MAP1LC3["MAP1LC3"] -->|"expressed in"| SMAD2["SMAD2"]
    P62["P62"] -->|"expressed in"| SMAD2["SMAD2"]
    style SMAD2 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (193)

Target	Relation	Type	Str
mitophagy	regulates	pathway	0.90
TGF-beta signaling	component_of	pathway	0.90
alpha-synuclein induced toxicity	protects_against	process	0.90
Tissue Fibrosis	associated_with	disease	0.80
Renal Fibrosis	involved_in	disease	0.80
Renal Fibrosis	contributes_to	disease	0.78
Als	activates	disease	0.75
Als	associated_with	disease	0.75
Inflammation	activates	disease	0.75
Tumor	activates	disease	0.75
TGF-beta signaling	participates_in	pathway	0.70
MITOPHAGY	activates	gene	0.70
SMAD3	regulates	gene	0.70
Tgf-Β	regulates	pathway	0.70
AKT	activates	gene	0.70
Hepatic Fibrosis	inhibits	disease	0.70
INFLAMMATION	activates	gene	0.70
Mitophagy	activates	pathway	0.70
Cancer	associated_with	disease	0.65
Fibrosis	expressed_in	disease	0.65
Tumor	associated_with	disease	0.65
Colorectal Cancer	associated_with	disease	0.65
Aging	associated_with	disease	0.65
ALS	activates	disease	0.65
Fibrosis	activates	disease	0.65
Senescence	activates	disease	0.65
Ms	activates	disease	0.65
Multiple Sclerosis	therapeutic_target	disease	0.65
Autoimmune	therapeutic_target	disease	0.65
Cardiac	regulates	disease	0.65
Cancer	regulates	disease	0.65
Fibrosis	regulates	disease	0.65
Ms	therapeutic_target	disease	0.65
Als	regulates	disease	0.65
Diabetes	inhibits	disease	0.65
Tumor	therapeutic_target	disease	0.65
Cancer	therapeutic_target	disease	0.65
Aging	therapeutic_target	disease	0.65
Aging	inhibits	disease	0.65
Stroke	inhibits	disease	0.65
Als	inhibits	disease	0.65
Ischemia	inhibits	disease	0.65
Tumor	regulates	disease	0.65
Ms	inhibits	disease	0.65
Cancer	activates	disease	0.65
Chronic Kidney Disease	activates	disease	0.65
Breast Cancer	activates	disease	0.65
Prostate Cancer	activates	disease	0.65
Carcinoma	activates	disease	0.65
Alzheimer	activates	disease	0.65

Incoming (67)

Source	Relation	Type	Str
lycopene	inhibits	drug	0.80
AKT	activates	gene	0.70
SMAD7	inhibits	gene	0.70
APIGENIN	activates	drug	0.70
APIGENIN	inhibits	drug	0.70
SIRT1	inhibits	gene	0.65
APIGENIN	associated_with	drug	0.65
MAPK	causes	gene	0.60
KRAS	inhibits	gene	0.60
MAPK	inhibits	gene	0.60
SQSTM1	expressed_in	gene	0.60
P62	expressed_in	gene	0.60
PINK1	expressed_in	gene	0.60
SMAD3	expressed_in	gene	0.60
PARKIN	expressed_in	gene	0.60
PRKN	expressed_in	gene	0.60
MICROGLIA	associated_with	gene	0.60
KRAS	activates	gene	0.60
MAPK	activates	gene	0.60
KRAS	causes	gene	0.60
SMAD7	regulates	gene	0.60
BRAIN INJURY	activates	gene	0.60
ITGB8	activates	gene	0.60
LC3	activates	gene	0.60
GENES	activates	gene	0.60
IL-6	activates	gene	0.60
MIRNAS	expressed_in	gene	0.60
PRESENILIN	activates	gene	0.60
ROS	activates	gene	0.60
APOPTOSIS	activates	gene	0.60
TGFB	expressed_in	gene	0.60
BAX	activates	gene	0.60
CR1	activates	gene	0.60
SMAD3	associated_with	gene	0.60
MITOPHAGY	activates	gene	0.60
MICRORNAS	therapeutic_target	gene	0.60
ALZHEIMER	activates	gene	0.60
MAP1LC3	activates	gene	0.60
BNIP3L	activates	gene	0.60
SMAD4	regulates	gene	0.60
LC3	expressed_in	gene	0.60
TUBULIN	activates	gene	0.60
SMAD1	activates	gene	0.60
GFAP	activates	gene	0.60
APP	activates	gene	0.60
DCX	activates	gene	0.60
BNIP3	activates	gene	0.60
TGFB1	activates	gene	0.60
FUNDC1	activates	gene	0.60
SMAD3	regulates	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
TGF-β1–SMAD2/3 Axis as Master Suppressor of Microglial Train	0.712	neuroinflammation	What specific astrocyte-derived factors

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning SMAD2 in their description or question text

No additional research found