gene

TNFA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TNFA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

414Connections

0Hypotheses

2Analyses

50Outgoing

50Incoming

0Experiments

3Debates

Summary

TNFA is a gene implicated in neurodegeneration research. Key relationships include: associated with, causes, co discussed. Associated with Aging, Als, Alzheimer. Connected to 113 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	TNF
Full Name	Tumor Necrosis Factor Alpha
Chromosome	6p21.33
Protein Family	TNF superfamily
Protein Type	Signaling Protein
Target Class	Signaling Protein
Function	Monoclonal antibodies or soluble receptors that neutralize TNF-alpha activity
Mechanism of Action	Monoclonal antibodies or soluble receptors that neutralize TNF-alpha activity
Druggability	Medium (0.50)
Clinical Stage	Approved
Molecular Weight	26 kDa
Exons	3
Pathways	Glucocorticoid receptor / stress response
UniProt ID	P01375
NCBI Gene ID	7124
Ensembl ID	ENSG00000232810
OMIM	191160
GeneCards	TNF
Human Protein Atlas	TNF
Associated Diseases	Aging, Als, Alzheimer, Cancer
Known Drugs/Compounds	curcumin, rapamycin, resveratrol
Interactions	ADAM17, ALZHEIMER, AND, ANGPTL4, APOE, ASC
SciDEX Target	View Target Profile (8 clinical trials)
KG Connections	414 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: TNFA — AlphaFold P01375 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (7)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    TNFA["TNFA"] -->|"associated"| neurodegeneration["neurodegeneration"]
    TNFA["TNFA"] -->|"interacts"| NR3C1["NR3C1"]
    TNFA["TNFA"] -->|"interacts"| CRH["CRH"]
    TNFA["TNFA"] -->|"co discussed"| PPARGC1A["PPARGC1A"]
    TNFA["TNFA"] -->|"co discussed"| PRKAA1["PRKAA1"]
    TNFA["TNFA"] -->|"co discussed"| NR3C1_1["NR3C1"]
    NR3C1_2["NR3C1"] -->|"interacts"| TNFA["TNFA"]
    CRH_3["CRH"] -->|"interacts"| TNFA["TNFA"]
    FOXP3["FOXP3"] -->|"co discussed"| TNFA["TNFA"]
    style TNFA fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (242)

Target	Relation	Type	Str
Neuroinflammation	mediates	process	0.90
A1 astrocyte	causes	cell_type	0.80
RGC death	causes	process	0.80
A1 astrocyte	inhibits	cell_type	0.80
Tumor	associated_with	disease	0.75
Cancer	associated_with	disease	0.75
Stem Cell	associated_with	pathway	0.70
CANCER	associated_with	gene	0.70
Parkinson	associated_with	disease	0.65
Alzheimer	associated_with	disease	0.65
Senescence	associated_with	disease	0.65
Neuroinflammation	associated_with	disease	0.65
Neurodegeneration	associated_with	disease	0.65
Inflammatory Bowel Disease	associated_with	disease	0.65
Colorectal Cancer	associated_with	disease	0.65
Cardiovascular	associated_with	disease	0.65
neurodegeneration	associated_with	disease	0.65
Als	associated_with	disease	0.65
Aging	associated_with	disease	0.65
Inflammation	associated_with	disease	0.65
Als	activates	disease	0.65
Anxiety	regulates	disease	0.65
Ms	causes	disease	0.65
Depression	regulates	disease	0.65
microglia	expressed_in	cell_type	0.65
ALS	associated_with	disease	0.65
ALS	activates	disease	0.65
neurons	expressed_in	cell_type	0.65
Parkinson	activates	disease	0.65
Neurodegeneration	activates	disease	0.65
Aging	activates	disease	0.65
Alzheimer	causes	disease	0.65
Rheumatoid Arthritis	therapeutic_target	disease	0.65
Neurodegeneration	causes	disease	0.65
Inflammation	causes	disease	0.65
Aging	causes	disease	0.65
Parkinson	causes	disease	0.65
Alzheimer	activates	disease	0.65
KCNK2	regulates	gene	0.64
TRPA1	activates	gene	0.64
TRPM8	activates	gene	0.64
NR3C1	interacts_with	gene	0.61
CRH	interacts_with	gene	0.61
Glucocorticoid receptor / stress response	participates_in	pathway	0.61
Unfolded Protein Response	associated_with	pathway	0.60
NFKB	activates	pathway	0.60
Mapk	associated_with	pathway	0.60
Nf-Kb	associated_with	pathway	0.60
Microrna	associated_with	pathway	0.60
ATG	associated_with	gene	0.60

Incoming (172)

Source	Relation	Type	Str
high glucose	upregulates	compound	0.90
h-cc1076c1	targets	hypothesis	0.90
h-1e564178	targets	hypothesis	0.90
Glucose	upregulates	compound	0.85
IL1B	associated_with	gene	0.80
OCULAR HYPERTENSION	upregulates	process	0.80
CRH	interacts_with	gene	0.61
NR3C1	interacts_with	gene	0.61
AGING	associated_with	gene	0.60
PARKINSON	associated_with	gene	0.60
ALZHEIMER	associated_with	gene	0.60
MICROGLIA	associated_with	gene	0.60
PARKINSON	activates	gene	0.60
ATG	activates	gene	0.60
MAP1LC3	activates	gene	0.60
MAPK	activates	gene	0.60
ROS	activates	gene	0.60
ATG	regulates	gene	0.60
MAP1LC3	regulates	gene	0.60
MAPK	regulates	gene	0.60
ROS	regulates	gene	0.60
ANGPTL4	interacts_with	gene	0.60
ITGB8	interacts_with	gene	0.60
IKK	activates	gene	0.60
TJP1	causes	gene	0.60
SMARCA4	activates	gene	0.60
CYTOKINES	therapeutic_target	gene	0.60
RIPK2	activates	gene	0.60
IL8	therapeutic_target	gene	0.60
RIPK2	associated_with	gene	0.60
BECN1	associated_with	gene	0.60
IL6	therapeutic_target	gene	0.60
NOD2	activates	gene	0.60
TNF	activates	gene	0.60
FYN	activates	gene	0.60
STAT3	activates	gene	0.60
IL1B	activates	gene	0.60
LC3	associated_with	gene	0.60
ERN1	associated_with	gene	0.60
PYCARD	associated_with	gene	0.60
NOD2	associated_with	gene	0.60
ULK1	associated_with	gene	0.60
BRG1	associated_with	gene	0.60
SQSTM1	associated_with	gene	0.60
STAT3	associated_with	gene	0.60
MELK	associated_with	gene	0.60
SMARCA4	associated_with	gene	0.60
STAT3	causes	gene	0.60
IL12A	activates	gene	0.60
FYN	causes	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (2)

Scientific analyses that reference this entity

Neuroinflammation and microglial priming in early Alzheimer's Disease

neurodegeneration | 2026-04-04 | 14 hypotheses Top: 0.651

Digital biomarkers and AI-driven early detection of neurodegeneration

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.756

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (3)

Multi-agent debates referencing this entity

Related Research

Hypotheses and analyses mentioning TNFA in their description or question text

No additional research found

TNFA

Understanding Entity Pages

Summary

Wiki Pages (7)

Tumor Necrosis Factor Alpha (TNF-α) as a Neurodegenerative Disease Biomarker

TNFAIP3 — TNF Alpha Induced Protein 3 (A20)

TNFAIP6 — TNF Alpha Induced Protein 6 (TSG-6)

TNFAIP1 — TNF Alpha Induced Protein 1

TNFAIP8L1 — TNF Alpha Induced Protein 8 Like 1

TNFAIP8 — TNF Alpha Induced Protein 8 (SCC-S2)

Pathway Diagram

Outgoing (242)

Incoming (172)

Targeting Hypotheses (0)

Mentioning Analyses (2)

Neuroinflammation and microglial priming in early Alzheimer's Disease

Digital biomarkers and AI-driven early detection of neurodegeneration

Experiments (0)

Related Papers (0)

Debates (3)

Investigate mechanistic links between early microglial priming states, neuroinfl

Investigate mechanistic links between early microglial priming states, neuroinfl

Can speech, gait, retinal imaging, sleep, and smartphone data detect neurodegene

Related Research

TNFA

Understanding Entity Pages

Summary

Wiki Pages (7)

Tumor Necrosis Factor Alpha (TNF-α) as a Neurodegenerative Disease Biomarker

TNFAIP3 — TNF Alpha Induced Protein 3 (A20)

TNFAIP6 — TNF Alpha Induced Protein 6 (TSG-6)

TNFAIP1 — TNF Alpha Induced Protein 1

TNFAIP8L1 — TNF Alpha Induced Protein 8 Like 1

TNFAIP8 — TNF Alpha Induced Protein 8 (SCC-S2)

TNFAIP3 Protein

Pathway Diagram

Outgoing (242)

Incoming (172)

Targeting Hypotheses (0)

Mentioning Analyses (2)

Neuroinflammation and microglial priming in early Alzheimer's Disease

Digital biomarkers and AI-driven early detection of neurodegeneration

Experiments (0)

Related Papers (0)

Debates (3)

Investigate mechanistic links between early microglial priming states, neuroinfl

Investigate mechanistic links between early microglial priming states, neuroinfl

Can speech, gait, retinal imaging, sleep, and smartphone data detect neurodegene

Related Research