protein

ADAM17

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ADAM17: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

178Connections

0Hypotheses

3Analyses

50Outgoing

50Incoming

0Experiments

3Debates

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🔬 Protein Info

Gene Symbol	ADAM17
Chromosome	2p25.1
Function	is a transmembrane zinc-dependent metalloproteinase that functions as the primary alpha-secretase for amyloid precursor protein (APP) processing.
Exons	22
Pathways	Notch, Apoptosis, Stem Cell, Phagocytosis, Amyloid
GeneCards	ADAM17
Human Protein Atlas	ADAM17
Associated Diseases	Cancer, Neurodegeneration
Interactions	Actin, AD, ADAM10, ALZHEIMER, ALZHEIMER DISEASE, AMYLOID
KG Connections	178 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

adam17

gene · 2000 words

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ADAM17 Protein

protein · 1100 words

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Pathway Diagram

graph TD
    ADAM17["ADAM17"] -->|"activates"| TNF_alpha["TNF-alpha"]
    style TNF_alpha fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    ADAM17["ADAM17"] -->|"activates"| EGFR_ligands["EGFR ligands"]
    style EGFR_ligands fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    ADAM17["ADAM17"] -->|"regulates"| epithelial_tissue_development["epithelial tissue development"]
    style epithelial_tissue_development fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    ADAM17["ADAM17"] -->|"regulates"| p75NTR["p75NTR"]
    style p75NTR fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    ADAM17["ADAM17"] -->|"regulates"| tPA["tPA"]
    style tPA fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    ADAM17["ADAM17"] -->|"regulates"| fibrin["fibrin"]
    style fibrin fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    ADAM17["ADAM17"] -->|"regulates"| nerve_conduction_velocity["nerve_conduction_velocity"]
    style nerve_conduction_velocity fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    PDK1["PDK1"] -->|"regulates"| ADAM17["ADAM17"]
    style PDK1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    ERK1_2["ERK1/2"] -->|"regulates"| ADAM17["ADAM17"]
    style ERK1_2 fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    RSK2["RSK2"] -->|"regulates"| ADAM17["ADAM17"]
    style RSK2 fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    iRhom2["iRhom2"] -->|"regulates"| ADAM17["ADAM17"]
    style iRhom2 fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    APOPTOSIS["APOPTOSIS"] -->|"expressed in"| ADAM17["ADAM17"]
    style APOPTOSIS fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    style ADAM17 fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (118)

Target	Relation	Type	Str
TNF-alpha	activates	protein	0.90
EGFR ligands	activates	protein	0.90
epithelial tissue development	regulates	phenotype	0.90
nerve_conduction_velocity	regulates	phenotype	0.80
tPA	regulates	enzyme	0.80
p75NTR	regulates	receptor	0.80
macrophage_recruitment	regulates	biological_process	0.80
fibrin	regulates	chemical	0.80
BACE1	activates	gene	0.70
GSK3B	activates	gene	0.70
APP	expressed_in	gene	0.70
cognitive_function	regulates	phenotype	0.70
endothelium-dependent_vasodilation	regulates	biological_process	0.70
Cancer	implicated_in	disease	0.65
Neurodegeneration	implicated_in	disease	0.65
DAM microglia	expressed_in	cell_type	0.65
Cancer	expressed_in	disease	0.65
Leukemia	expressed_in	disease	0.65
Als	expressed_in	disease	0.65
APP	inhibits	gene	0.65
APP	activates	gene	0.65
Alzheimer	activates	disease	0.65
LRP1	activates	gene	0.60
SIGLEC11	implicated_in	gene	0.60
CANCER	expressed_in	gene	0.60
GENES	expressed_in	gene	0.60
Notch	expressed_in	pathway	0.60
Apoptosis	expressed_in	pathway	0.60
SORL1	associated_with	gene	0.60
SPI1	associated_with	gene	0.60
TMEM106B	associated_with	gene	0.60
TREM2	associated_with	gene	0.60
ABI3	associated_with	gene	0.60
TAU	activates	gene	0.60
AND	associated_with	gene	0.60
COMPLEMENT	activates	gene	0.60
ALZHEIMER DISEASE	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
TAU PATHOLOGY	activates	gene	0.60
Phagocytosis	associated_with	pathway	0.60
MTOR	inhibits	gene	0.60
AΒ	inhibits	gene	0.60
APOE	associated_with	gene	0.60
APP	associated_with	gene	0.60
BIN1	associated_with	gene	0.60
CD2AP	associated_with	gene	0.60
CD33	associated_with	gene	0.60
CLU	associated_with	gene	0.60
CR1	associated_with	gene	0.60
CTSB	associated_with	gene	0.60

Incoming (60)

Source	Relation	Type	Str
genes-adam17	describes	wiki_page	0.95
h-trem2-fe8c644a	targets_gene	hypothesis	0.90
ALZHEIMER DISEASE	associated_with	gene	0.80
PDK1	regulates	gene	0.70
RSK2	regulates	protein	0.70
iRhom2	regulates	protein	0.70
ERK1/2	regulates	protein	0.70
COMPLEMENT	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
CD2AP	associated_with	gene	0.60
APOE	associated_with	gene	0.60
CR1	associated_with	gene	0.60
BIN1	associated_with	gene	0.60
LILRB2	associated_with	gene	0.60
PLCG2	associated_with	gene	0.60
CLU	associated_with	gene	0.60
TREM2	associated_with	gene	0.60
CD33	associated_with	gene	0.60
ABI3	associated_with	gene	0.60
AMYLOID	activates	gene	0.60
PHAGOCYTOSIS	associated_with	gene	0.60
ACE	associated_with	gene	0.60
ABCA1	associated_with	gene	0.60
ADAM10	targets	gene	0.60
ADAM10	expressed_in	gene	0.60
TGFB	associated_with	gene	0.60
ADAM10	activates	gene	0.60
ADAM10	degrades	gene	0.60
CTSB	associated_with	gene	0.60
PSEN1	associated_with	gene	0.60
SORL1	associated_with	gene	0.60
EED	associated_with	gene	0.60
APOPTOSIS	expressed_in	gene	0.60
TAU	activates	gene	0.60
GENES	associated_with	gene	0.60
AND	associated_with	gene	0.60
ANGPTL4	associated_with	gene	0.60
TMEM106B	associated_with	gene	0.60
TNFA	associated_with	gene	0.60
USH2A	associated_with	gene	0.60
EPHB4	associated_with	gene	0.60
IL6	associated_with	gene	0.60
GRN	associated_with	gene	0.60
IL1B	associated_with	gene	0.60
NEURODEGENERATION	implicated_in	gene	0.60
ITGB8	associated_with	gene	0.60
AD	activates	gene	0.60
CTSH	associated_with	gene	0.60
PTK2B	associated_with	gene	0.60
LRP1	activates	gene	0.60