protein

SMAD

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SMAD: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

112Connections

2Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

Page for SMAD Family Member 6

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🔬 Protein Info

Gene Symbol	SMAD
Molecular Weight	49 kDa
Pathways	TGF-β signaling, JAK-STAT Signaling, jak-stat, TGF-β
GeneCards	SMAD
Human Protein Atlas	SMAD
Known Drugs/Compounds	rapamycin
Interactions	acvr1, AKT, ALZHEIMER, APOE, ATG, CDKN1A
KG Connections	111 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (16)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    SMAD["SMAD"]
    BMPR1B["BMPR1B"]
    BMPR1B -->|"participates in"| SMAD
    Tgf__["Tgf-Beta"]
    SMAD -->|"regulates"| Tgf__
    BAMBI["BAMBI"]
    SMAD -->|"regulates"| BAMBI
    inflammation["inflammation"]
    SMAD -->|"regulates"| inflammation
    MAPK["MAPK"]
    SMAD -->|"regulates"| MAPK
    NF__B["NF-kappaB"]
    SMAD -->|"regulates"| NF__B
    CYTOKINES["CYTOKINES"]
    SMAD -->|"regulates"| CYTOKINES
    BRAIN_INFLAMMATION["BRAIN INFLAMMATION"]
    SMAD -->|"regulates"| BRAIN_INFLAMMATION
    CYTOKINE["CYTOKINE"]
    SMAD -->|"regulates"| CYTOKINE
    MAPK["MAPK"]
    SMAD -->|"associated with"| MAPK
    Tgf__["Tgf-Beta"]
    SMAD -->|"associated with"| Tgf__
    CYTOKINES["CYTOKINES"]
    SMAD -->|"associated with"| CYTOKINES
    ENDOTHELIAL["ENDOTHELIAL"]
    SMAD -->|"associated with"| ENDOTHELIAL
    Reactive_Oxygen_Species["Reactive Oxygen Species"]
    SMAD -->|"associated with"| Reactive_Oxygen_Species
    inflammation["inflammation"]
    SMAD -->|"activates"| inflammation
    NF__B["NF-kappaB"]
    SMAD -->|"activates"| NF__B
    MACROPHAGES["MACROPHAGES"]
    SMAD -->|"activates"| MACROPHAGES
    STEM_CELLS["STEM CELLS"]
    SMAD -->|"activates"| STEM_CELLS
    Neuron["Neuron"]
    SMAD -->|"associated with"| Neuron
    NEURONS["NEURONS"]
    SMAD -->|"associated with"| NEURONS
    Neuron["Neuron"]
    SMAD -->|"regulates"| Neuron
    NEURONS["NEURONS"]
    SMAD -->|"regulates"| NEURONS
    ALZHEIMER["ALZHEIMER"]
    SMAD -->|"activates"| ALZHEIMER
    Alzheimer_S_Disease["Alzheimer'S Disease"]
    SMAD -->|"activates"| Alzheimer_S_Disease
    Neurogenesis["Neurogenesis"]
    SMAD -->|"activates"| Neurogenesis
    disease["disease"]
    SMAD -->|"activates"| disease
    ALZHEIMER_S["ALZHEIMER'S"]
    SMAD -->|"activates"| ALZHEIMER_S
    SMAD4["SMAD4"]
    SMAD -->|"activates"| SMAD4
    TUBULIN["TUBULIN"]
    SMAD -->|"activates"| TUBULIN
    Reactive_Oxygen_Species["Reactive Oxygen Species"]
    SMAD -->|"activates"| Reactive_Oxygen_Species

Outgoing (56)

Target	Relation	Type	Str
TGF	regulates	gene	0.60
SORL1	implicated_in	gene	0.60
TGF	implicated_in	gene	0.60
SORL1	activates	gene	0.60
SORL1	regulates	gene	0.60
SQSTM1	activates	gene	0.60
TGFB	activates	gene	0.60
TP53	activates	gene	0.60
Alzheimer's disease	activates	disease	0.60
Parkinson's disease	activates	disease	0.60
autophagy pathway	participates_in	pathway	0.60
oxidative stress response	participates_in	pathway	0.60
senescence	participates_in	pathway	0.60
ubiquitin-proteasome	participates_in	pathway	0.60
TIMP1	expressed_in	gene	0.60
NF-kB signaling	participates_in	pathway	0.60
PI3K-AKT-mTOR signaling	participates_in	pathway	0.60
apoptosis pathway	participates_in	pathway	0.60
STAT3	interacts_with	gene	0.60
TGF	interacts_with	gene	0.60
VEGF	interacts_with	gene	0.60
JAK-STAT signaling	participates_in	pathway	0.60
TGF	activates	gene	0.55
neurons	expressed_in	cell_type	0.55
TGF-beta signaling	participates_in	pathway	0.55
macrophages	expressed_in	cell_type	0.55
SMAD4	activates	protein	0.50
TUBULIN	activates	protein	0.50
Tgf-Β	regulates	pathway	0.50
TIMP1	co_expressed_with	gene	0.50
Reactive Oxygen Species	activates	process	0.50
BAMBI	regulates	concept	0.50
inflammation	regulates	pathway	0.50
MAPK	regulates	gene	0.50
NF-κB	regulates	concept	0.50
CYTOKINES	regulates	concept	0.50
BRAIN INFLAMMATION	regulates	concept	0.50
CYTOKINE	regulates	concept	0.50
MAPK	associated_with	gene	0.50
Tgf-Β	associated_with	pathway	0.50
CYTOKINES	associated_with	concept	0.50
ENDOTHELIAL	associated_with	concept	0.50
Reactive Oxygen Species	associated_with	process	0.50
inflammation	activates	pathway	0.50
NF-κB	activates	concept	0.50
MACROPHAGES	activates	concept	0.50
STEM CELLS	activates	concept	0.50
Neuron	associated_with	cell_type	0.50
NEURONS	associated_with	concept	0.50
Neuron	regulates	cell_type	0.50

Incoming (56)

Source	Relation	Type	Str
TGF-β1	activates	protein	0.80
BMPR1B	participates_in	gene	0.70
RNA	regulates	gene	0.70
JAK	activates	gene	0.60
MTOR	activates	gene	0.60
PCNA	activates	gene	0.60
PI3K	activates	gene	0.60
PIK3CA	activates	gene	0.60
PSMA1	activates	gene	0.60
PSMB5	activates	gene	0.60
RPS6KB1	activates	gene	0.60
rapamycin	targets	drug	0.60
AKT	expressed_in	gene	0.60
MMP14	expressed_in	gene	0.60
MMP2	expressed_in	gene	0.60
MMP9	expressed_in	gene	0.60
PI3K	expressed_in	gene	0.60
AKT	regulates	gene	0.60
PDK1	regulates	gene	0.60
PI3K	regulates	gene	0.60
ACSL5	regulates	gene	0.60
BAMBI	regulates	gene	0.60
RNA	activates	gene	0.60
ROS	activates	gene	0.60
NOTCH1	regulates	gene	0.60
AKT	activates	gene	0.60
ATG	activates	gene	0.60
CDKN1A	activates	gene	0.60
CDKN2A	activates	gene	0.60
DMSO	activates	gene	0.60
EIF4EBP1	activates	gene	0.60
GLB1	activates	gene	0.60
LC3	activates	gene	0.60
MAP1LC3	activates	gene	0.60
MKI67	activates	gene	0.60
LOX	activates	gene	0.55
LOXL2	activates	gene	0.55
LOXL4	activates	gene	0.55
HIF	activates	gene	0.55
APOE	activates	gene	0.50
SORL1	activates	gene	0.50
APOE	regulates	gene	0.50
SORL1	regulates	gene	0.50
SMAD3	activates	gene	0.50
GFAP	activates	gene	0.50
SMAD1	activates	gene	0.50
SMAD2	activates	gene	0.50
PI3K	co_expressed_with	protein	0.50
PTEN	co_expressed_with	gene	0.50
PPARGC1A	regulates	gene	0.50

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
TGF-β1–SMAD2/3 Axis as Master Suppressor of Microglial Train	0.688	neuroinflammation	What specific astrocyte-derived factors
TGF-β1-SMAD Signaling Dysregulation	0.380	neurodegeneration	Which specific factors in conditioned me

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning SMAD in their description or question text

No additional research found

SMAD

Understanding Entity Pages

Summary

Wiki Pages (16)

SMAD3 — SMAD Family Member 3

SMAD6 — SMAD Family Member 6

SMAD5 — SMAD Family Member 5

SMAD5 Protein

SMAD7 Gene

SMAD9 — SMAD Family Member 9

SMAD2 Gene

SMAD4 — SMAD Family Member 4

SMAD4 Protein

SMAD2 Protein

SMAD1 Protein

SMAD1 Gene

SMAD Family Member 9

SMAD Family Member 6

SMAD Family Member 3

SMAD Family Member 7