protein

PSMA1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PSMA1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

30Connections
0Hypotheses
0Analyses
15Outgoing
15Incoming
0Experiments
0Debates

Summary

Page for PSMA1 Protein

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🔬 Protein Info
Gene SymbolPSMA1
Full NameProteasome 20S Subunit Alpha 1
Chromosome11p15.2
Functionis an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight27.6 kDa
Amino Acids263 aa
NCBI Gene ID5682
Ensembl IDENSG00000129084
GeneCardsPSMA1
Human Protein AtlasPSMA1
Associated Diseasesneurodegeneration
Known Drugs/Compoundsrapamycin
InteractionsAKT, ATG, CDKN1A, CDKN2A, DMSO, EIF4EBP1
KG Connections30 knowledge graph edges
DatabasesGeneCardsUniProtHPASTRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

PSMA1 Gene

gene · 983 words

PSMA1 Protein

protein · 1115 words

Pathway Diagram

flowchart TD
    N0["PSMA1"]
    N1["AKT"]
    N1 -->|"activates"| N0
    N2["PSMB5"]
    N0 -->|"activates"| N2
    N3["RPS6KB1"]
    N0 -->|"activates"| N3
    N4["SMAD"]
    N0 -->|"activates"| N4
    N5["SQSTM1"]
    N0 -->|"activates"| N5
    N6["TGFB"]
    N0 -->|"activates"| N6
    N7["TP53"]
    N0 -->|"activates"| N7
    N8["Alzheimer's disease"]
    N0 -->|"activates"| N8
    N9["Parkinson's disease"]
    N0 -->|"activates"| N9

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    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    classDef drug fill:#1a2a2a,stroke:#26c6da,color:#e0e0e0
    classDef cell_type fill:#2a1a2a,stroke:#ab47bc,color:#e0e0e0
    classDef phenotype fill:#2a2a1a,stroke:#ffa726,color:#e0e0e0
    classDef process fill:#1a2a2a,stroke:#66bb6a,color:#e0e0e0
    classDef biological_process fill:#1a2a2a,stroke:#66bb6a,color:#e0e0e0
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    classDef entity fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef therapeutic fill:#1a2a2a,stroke:#26c6da,color:#e0e0e0
    classDef index fill:#1a1a2a,stroke:#7986cb,color:#e0e0e0
    class N0 protein
    class N1 gene
    class N2 gene
    class N3 gene
    class N4 gene
    class N5 gene
    class N6 gene
    class N7 gene
    class N8 disease
    class N9 disease

Outgoing (15)

TargetRelationTypeStr
ROSactivatesgene0.60
PI3K-AKT-mTOR signalingparticipates_inpathway0.60
PSMB5activatesgene0.60
RPS6KB1activatesgene0.60
SQSTM1activatesgene0.60

Incoming (15)

SourceRelationTypeStr
AKTactivatesgene0.60
CDKN1Aactivatesgene0.60
CDKN2Aactivatesgene0.60
EIF4EBP1activatesgene0.60
GLB1activatesgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

ExperimentTypeDiseaseScoreFeasibilityModelStatusEst. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PSMA1 in their description or question text

No additional research found