protein

USH2A

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about USH2A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

30Connections

0Hypotheses

0Analyses

10Outgoing

20Incoming

0Experiments

0Debates

Summary

Page for USH2A Protein

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🔬 Protein Info

Gene Symbol	USH2A
Full Name	Usherin
Chromosome	1q41
Protein Type	Protein
Function	The protein localizes to the photoreceptor outer segments where it participates in disc membrane maintenance.
Primary Expression	different tissues
Subcellular Localization	s and functions. [@gelfman2022]
Molecular Weight	171 kDa
Amino Acids	600 aa
Exons	72
UniProt ID	[Q9NZU7](https://www.uniprot.org/uniprot/Q9NZU7)
NCBI Gene ID	7399
Ensembl ID	ENSG00000042781
OMIM	608400
GeneCards	USH2A
Human Protein Atlas	USH2A
Associated Diseases	neurodegeneration
Interactions	ADAM17, ANGPTL4, APOE, EPHB4, IL1B, IL6
KG Connections	30 knowledge graph edges
Databases	GeneCards HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

USH2A Protein

protein · 2866 words

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USH2A Gene

gene · 712 words

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Pathway Diagram

graph TD
    USH2A["USH2A"]
    APOE(["APOE"])
    USH2A -->|"associated_with"| APOE
    EPHB4(["EPHB4"])
    USH2A -->|"associated_with"| EPHB4
    IL6(["IL6"])
    USH2A -->|"associated_with"| IL6
    ADAM17(["ADAM17"])
    USH2A -->|"associated_with"| ADAM17
    TGFB(["TGFB"])
    USH2A -->|"associated_with"| TGFB
    ANGPTL4(["ANGPTL4"])
    USH2A -->|"associated_with"| ANGPTL4
    ITGB8(["ITGB8"])
    ITGB8 -->|"associated_with"| USH2A
    IL1B(["IL1B"])
    IL1B -->|"associated_with"| USH2A
    TNFA(["TNFA"])
    TNFA -->|"associated_with"| USH2A
    style USH2A fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#4fc3f7

Outgoing (10)

Target	Relation	Type	Str
Retinitis Pigmentosa	risk_factor_for	disease	0.85
EPHB4	associated_with	gene	0.60
IL6	associated_with	gene	0.60
ADAM17	associated_with	gene	0.60
TNFA	associated_with	gene	0.60
APOE	associated_with	gene	0.60
TGFB	associated_with	gene	0.60
ANGPTL4	associated_with	gene	0.60
ITGB8	associated_with	gene	0.60
IL1B	associated_with	gene	0.60

Incoming (20)

Source	Relation	Type	Str
ANGPTL4	interacts_with	gene	0.60
ITGB8	interacts_with	gene	0.60
IL6	associated_with	gene	0.60
APOE	associated_with	gene	0.60
EPHB4	associated_with	gene	0.60
ADAM17	associated_with	gene	0.60
GENES	associated_with	gene	0.60
AND	associated_with	gene	0.60
ANGPTL4	associated_with	gene	0.60
TGFB	associated_with	gene	0.60
PKM2	interacts_with	gene	0.60
IL1B	associated_with	gene	0.60
TNFA	associated_with	gene	0.60
IL6	interacts_with	gene	0.60
ITGB8	associated_with	gene	0.60
APOE	interacts_with	gene	0.50
ADAM17	interacts_with	protein	0.50
IL1B	interacts_with	gene	0.50
TNFA	interacts_with	gene	0.50
EPHB4	interacts_with	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning USH2A in their description or question text

No additional research found