concept

GLIOMA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GLIOMA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

656Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

GLIOMA is a concept in neurodegeneration research. Key relationships include: co discussed, regulates, treats. Associated with ALZHEIMER, ALZHEIMER'S, CANCER. Connected to 32 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	GLIOMA
Key Genes/Proteins	ACHE, AKT, AMPK, APP, BAX
Related Diseases	ALS, ALZHEIMER, ALZHEIMER'S, ALZHEIMER'S DISEASE, AMYOTROPHIC LATERAL SCLEROSIS

Pathway Diagram

graph TD
    GLIOMA["GLIOMA"]
    GLIOMA -->|"target for"| Autophagy["Autophagy"]
    GLIOMA -->|"regulates"| Cell_Cycle["Cell Cycle"]
    GLIOMA -->|"regulates"| Mtor["Mtor"]
    GLIOMA -->|"activates"| Complement["Complement"]
    GLIOMA -->|"activates"| Mapk["Mapk"]
    GLIOMA -->|"target for"| Akt["Akt"]
    GLIOMA -->|"target for"| Pi3K["Pi3K"]
    pericyte_senescence["pericyte senescence"] -->|"activates"| GLIOMA
    CBD["CBD"] -->|"treats"| GLIOMA
    TRPV4["TRPV4"] -.biomarker for.-> GLIOMA
    doxorubicin["doxorubicin"] -->|"treats"| GLIOMA
    mitophagy["mitophagy"] -->|"causes"| GLIOMA
    temozolomide["temozolomide"] -->|"treats"| GLIOMA
    cannabidiol["cannabidiol"] -->|"treats"| GLIOMA
    ATRX["ATRX"] -.biomarker for.-> GLIOMA
    BRAF["BRAF"] -.biomarker for.-> GLIOMA
    CIC["CIC"] -.biomarker for.-> GLIOMA

Outgoing (237)

Target	Relation	Type	Str
Als	therapeutic_target	disease	1.00
Als	activates	disease	1.00
Glioblastoma	associated_with	disease	0.95
Cancer	therapeutic_target	disease	0.95
Glioblastoma	activates	disease	0.95
Neurodegeneration	activates	disease	0.85
Glioblastoma	therapeutic_target	disease	0.85
Als	associated_with	disease	0.85
Stress Granules	associated_with	process	0.80
Autophagy	activates	pathway	0.80
Blood-Brain Barrier	therapeutic_target	pathway	0.80
Apoptosis	activates	pathway	0.80
Stem Cell	activates	pathway	0.80
Glioblastoma	regulates	disease	0.75
Cancer	regulates	disease	0.75
Cancer	activates	disease	0.75
Apoptosis	therapeutic_target	pathway	0.70
Pi3K/Akt	therapeutic_target	pathway	0.70
Mtor	activates	pathway	0.70
Tumor Microenvironment	therapeutic_target	pathway	0.70
Invasion	regulates	pathway	0.70
Chemoresistance	activates	pathway	0.70
Stem Cell	therapeutic_target	pathway	0.70
Ferroptosis	activates	pathway	0.70
intratumoral heterogeneity	associated_with	process	0.70
Differentiation	activates	pathway	0.70
Invasion	activates	pathway	0.70
Apoptosis	inhibits	pathway	0.70
Aging	therapeutic_target	disease	0.65
Als	inhibits	disease	0.65
Cancer	associated_with	disease	0.65
MACROPHAGE	associated_with	cell_type	0.65
Mtor	therapeutic_target	pathway	0.65
TUMOR	associated_with	disease	0.65
Aging	treats	disease	0.65
APP	associated_with	gene	0.65
LACTATE	interacts_with	phenotype	0.65
MACROPHAGES	associated_with	cell_type	0.65
Alzheimer	therapeutic_target	disease	0.65
Als	regulates	disease	0.65
Als	expressed_in	disease	0.65
T CELL	expressed_in	cell_type	0.65
STING	reduces	gene	0.65
MACROPHAGE	mediates	cell_type	0.65
PI3K	promotes	gene	0.65
PERICYTE	causes	cell_type	0.65
PERICYTE	contributes_to	cell_type	0.65
PI3K	activates	gene	0.65
Epithelial-Mesenchymal Transition	therapeutic_target	pathway	0.60
MAPK	causes	gene	0.60

Incoming (419)

Source	Relation	Type	Str
Tumor	activates	disease	1.00
CANCER	therapeutic_target	gene	1.00
Tumor	therapeutic_target	disease	1.00
GLIOBLASTOMA	activates	gene	1.00
Tumor	associated_with	disease	1.00
GLIOBLASTOMA	associated_with	gene	1.00
IDH2	associated_with	entity	0.98
IDH1	associated_with	entity	0.98
NEURODEGENERATION	activates	gene	0.95
LOXL1	associated_with	gene	0.92
LOXL3	associated_with	gene	0.92
LOXL2	associated_with	gene	0.92
LOXL4	associated_with	gene	0.92
LOX	associated_with	gene	0.92
1p/19q Codeletion	biomarker_for	biomarker	0.90
Claudins	promotes	protein	0.90
IDH2	biomarker_for	gene	0.90
Stress Granules	associated_with	process	0.90
1P/19Q Codeletion	biomarker_for	biomarker	0.90
AUTOPHAGY	activates	gene	0.85
Berberine-Inspired Ionizable Lipid	treats	compound	0.85
GBM	activates	gene	0.85
CANCER	activates	gene	0.85
EGFR	therapeutic_target	gene	0.85
LOX	biomarker_for	gene	0.85
CANCER	regulates	gene	0.85
Lox/Loxl Co-Expressed Genes	biomarker_for	biomarker	0.85
GLIOBLASTOMA	therapeutic_target	gene	0.85
GBM	therapeutic_target	gene	0.85
MCOLN1	targets	protein	0.85
APOPTOSIS	activates	gene	0.85
GLIOBLASTOMA	regulates	gene	0.85
PIEZO1	associated_with	protein	0.80
Senescence Associated Secretory Phenotype	associated_with	phenotype	0.80
CLDN1	downregulates	gene	0.80
HDAC inhibitors	treats	drug	0.80
Metal complexes (dicyanoargentate-based)	treats	compound	0.80
CLDN5	downregulates	gene	0.80
senescence	promotes	process	0.80
Piezo1	implicated_in	protein	0.80
LOX/LOXL	targets	enzyme	0.80
Senescence	contributes_to	process	0.80
Berberine-inspired Ionizable Lipid	treats	compound	0.80
COMT	associated_with	gene	0.80
GSDM Family	biomarker_for	protein	0.80
RPL39	biomarker_for	gene	0.80
Mutation-Specific Antibodies	biomarker_for	biomarker	0.80
KIF2A	associated_with	gene	0.80
B-series Gangliosides	associated_with	compound	0.80
STRESS GRANULES	associated_with	entity	0.80

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning GLIOMA in their description or question text

No additional research found