gene

NF1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NF1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

256Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

NF1 is a gene implicated in neurodegeneration research. Key relationships include: activates, associated with, regulates. Associated with Als, Ataxia, Cancer. Connected to 157 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	NF1
Full Name	Neurofibromin 1
Chromosome	17q11.2
Function	encodes a large tumor suppressor protein that negatively regulates the Ras signaling pathway.
Primary Expression	the nervous system:
Molecular Weight	327 kDa
Amino Acids	818 aa
Exons	60
Pathways	MAPK signaling
UniProt ID	[P21359](https://www.uniprot.org/uniprot/P21359)
Ensembl ID	ENSG00000196712
OMIM	613113
GeneCards	NF1
Human Protein Atlas	NF1
Neuronal development	Regulation of neural progenitor proliferation and differentiation
Associated Diseases	Als, Cancer, epilepsy, frontotemporal dementia
Interactions	AKT, AKT3, AND, BRAF, CANCER, CDK4
KG Connections	256 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (11)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    NF1["NF1"]
    NF1 -->|"causes"| neurofibromatosis_type_1["neurofibromatosis type 1"]
    NF1 -->|"causes"| Tumor["Tumor"]
    NF1 -->|"regulates"| RAS["RAS"]
    NF1 -->|"regulates"| MAPK["MAPK"]
    NF1 -->|"encodes"| neurofibromin["neurofibromin"]
    NF1 -->|"target for"| Cancer["Cancer"]
    NF1 -->|"target for"| Ms["Ms"]
    NF1 -->|"target for"| Glioblastoma["Glioblastoma"]
    BRAF["BRAF"] -->|"activates"| NF1
    TP53["TP53"] -->|"activates"| NF1
    EGFR["EGFR"] -->|"activates"| NF1
    RB1["RB1"] -->|"activates"| NF1
    TEAD1["TEAD1"] -->|"target for"| NF1
    GENES["GENES"] -->|"target for"| NF1
    MTOR["MTOR"] -->|"inhibits"| NF1
    ERK["ERK"] -->|"inhibits"| NF1
    PI3K["PI3K"] -->|"inhibits"| NF1
    AKT["AKT"] -->|"inhibits"| NF1

Outgoing (157)

Target	Relation	Type	Str
Als	associated_with	disease	0.95
neurofibromatosis type 1	causes	disease	0.90
Cancer	activates	disease	0.85
Tumor	inhibits	disease	0.85
MAPK	regulates	pathway	0.80
Tumor	causes	disease	0.80
RAS	regulates	pathway	0.80
Tumor	activates	disease	0.75
Als	treats	disease	0.75
Als	therapeutic_target	disease	0.75
Als	inhibits	disease	0.75
Tumor	treats	disease	0.75
Tumor	therapeutic_target	disease	0.75
Tumor	associated_with	disease	0.75
Glioblastoma	therapeutic_target	disease	0.75
Als	activates	disease	0.75
NF2	associated_with	gene	0.70
neurofibromin	encodes	protein	0.70
Glioblastoma	expressed_in	disease	0.65
Als	expressed_in	disease	0.65
Cirrhosis	expressed_in	disease	0.65
Ms	expressed_in	disease	0.65
Carcinoma	expressed_in	disease	0.65
Cancer	associated_with	disease	0.65
Cancer	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Ms	inhibits	disease	0.65
Glioblastoma	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Glioma	therapeutic_target	disease	0.65
Cancer	treats	disease	0.65
Cancer	regulates	disease	0.65
Ataxia	regulates	disease	0.65
Glioblastoma	activates	disease	0.65
Tumor	regulates	disease	0.65
Glioma	associated_with	disease	0.65
Colorectal Cancer	activates	disease	0.65
Melanoma	associated_with	disease	0.65
Epilepsy	associated_with	disease	0.65
ALS	associated_with	disease	0.65
Ms	activates	disease	0.65
ALS	inhibits	disease	0.65
Tumor	expressed_in	disease	0.65
Glioblastoma	regulates	disease	0.65
Melanoma	activates	disease	0.65
SOD1	activates	gene	0.60
AKT	expressed_in	gene	0.60
MTOR	expressed_in	gene	0.60
DYRK1A	associated_with	gene	0.60
MTOR	associated_with	gene	0.60

Incoming (99)

Source	Relation	Type	Str
genes-nf1	linked_to	wiki_page	1.00
SPRED1	interacts_with	protein	0.95
BRAF	activates	gene	0.80
TP53	activates	gene	0.70
BRAF	associated_with	gene	0.70
KRAS	associated_with	gene	0.60
MYCN	associated_with	gene	0.60
PTEN	associated_with	gene	0.60
RB1	associated_with	gene	0.60
TP53	regulates	gene	0.60
MTOR	expressed_in	gene	0.60
TLR4	activates	gene	0.60
PI3K	expressed_in	gene	0.60
SOD2	activates	gene	0.60
AKT	expressed_in	gene	0.60
SOD1	activates	gene	0.60
NOTCH3	activates	gene	0.60
FLCN	activates	gene	0.60
NOTCH1	activates	gene	0.60
ATM	regulates	gene	0.60
NBN	regulates	gene	0.60
BRIP1	regulates	gene	0.60
STK11	regulates	gene	0.60
CHEK2	regulates	gene	0.60
PTEN	regulates	gene	0.60
BRCA1	regulates	gene	0.60
PALB2	regulates	gene	0.60
RAD51	regulates	gene	0.60
GBM	associated_with	gene	0.60
IDH1	associated_with	gene	0.60
RHOT1	expressed_in	gene	0.60
SLC6A4	expressed_in	gene	0.60
RHEB	associated_with	gene	0.60
GENES	therapeutic_target	gene	0.60
DYRK1A	associated_with	gene	0.60
P53	associated_with	gene	0.60
CANCER	activates	gene	0.60
ERBB2	regulates	gene	0.60
CANCER	regulates	gene	0.60
CDH1	regulates	gene	0.60
CANCER	associated_with	gene	0.60
GLIOBLASTOMA	activates	gene	0.60
RAS	associated_with	gene	0.60
ERK	activates	gene	0.60
DNA	expressed_in	gene	0.60
GLIOBLASTOMA	therapeutic_target	gene	0.60
RAS	regulates	gene	0.60
CANCER	treats	gene	0.60
RAS	inhibits	gene	0.60
RAS	therapeutic_target	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning NF1 in their description or question text

No additional research found

NF1

Understanding Entity Pages

Summary

Wiki Pages (11)

NF1 — Neurofibromin 1

RNF128 (Graf1/XTP3) Gene

RNF11 — RING Finger Protein 11

KCNF1 Gene

RNF186 Protein

RNF182 Protein

RNF149 Protein

RNF115 Protein

RNF10 — Ring Finger Protein 10

RNF13 — Ring Finger Protein 13

RNF14 — Ring Finger Protein 14