concept

NF-KB

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NF-KB: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1663Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

NF-KB is a concept in neurodegeneration research. Key relationships include: activates, associated with, regulates. Associated with ALS, ALZHEIMER'S DISEASE, Aging. Connected to 482 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	NF-KB
Key Genes/Proteins	ABCA7, ABLIM1, ACETYLCHOLINE, ACHE, Actin, ACVR1
Related Diseases	Aging
Related Pathways	Akt

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

nf-kb

general · 1939 words

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Pathway Diagram

flowchart TD
    NF_KB(["NF-KB"])
    Nf_Kb["Nf-Kb"]
    Inflammation["Inflammation"]
    TNF__(["TNF-Alpha"])
    TNF(["TNF"])
    PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
    OXIDATIVE_STRESS["OXIDATIVE STRESS"]
    APOPTOSIS(["APOPTOSIS"])
    NEURODEGENERATION(["NEURODEGENERATION"])
    MICROGLIA["MICROGLIA"]
    NEUROINFLAMMATION["NEUROINFLAMMATION"]
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    AKT(["AKT"])
    CANCER(["CANCER"])

    NF_KB -->|"activates"| Nf_Kb
    NF_KB -->|"activates"| Inflammation
    NF_KB -->|"activates"| TNF__
    NF_KB -->|"associated with"| TNF
    NF_KB -->|"associated with"| PARKINSON_S_DISEASE
    NF_KB -->|"associated with"| OXIDATIVE_STRESS
    TNF -->|"activates"| NF_KB
    APOPTOSIS -->|"associated with"| NF_KB
    NEURODEGENERATION -->|"associated with"| NF_KB
    MICROGLIA -->|"associated with"| NF_KB
    NEUROINFLAMMATION -->|"associated with"| NF_KB
    ALZHEIMER_S_DISEASE -->|"associated with"| NF_KB
    AKT -->|"associated with"| NF_KB
    NF_KB -->|"regulates"| Nf_Kb
    NF_KB -->|"activates"| CANCER

    style NF_KB fill:#006494,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (754)

Target	Relation	Type	Str
MULTIPLE SCLEROSIS	associated_with	disease	1.00
MAPK	associated_with	gene	1.00
TAU	associated_with	protein	1.00
HIPPOCAMPUS	associated_with	brain_region	1.00
Inflammation	activates	disease	1.00
TNF	associated_with	gene	1.00
NRF2	associated_with	gene	1.00
NLRP3	associated_with	gene	1.00
MACROPHAGE	associated_with	cell_type	1.00
Nf-Kb	activates	pathway	1.00
NEURON	associated_with	cell_type	1.00
CORTEX	associated_with	brain_region	1.00
PARKINSON'S DISEASE	associated_with	disease	1.00
TLR4	associated_with	gene	1.00
PI3K	associated_with	gene	1.00
h-35cc314907	targeted_by	hypothesis	1.00
TNF-Α	activates	gene	1.00
CANCER	activates	gene	1.00
Nf-Kb	regulates	pathway	1.00
DEMENTIA	associated_with	disease	0.98
C3	associated_with	gene	0.98
GFAP	associated_with	protein	0.98
JAK	associated_with	gene	0.98
INOS	associated_with	gene	0.96
Neuroinflammation	activates	disease	0.95
Cancer	activates	disease	0.95
Inflammation	regulates	disease	0.95
Alzheimer's Disease	involved_in	disease	0.95
Neurodegeneration	contributes_to	process	0.90
IL6	regulates	protein	0.90
STAT3	associated_with	gene	0.90
p62/SQSTM1	regulates	protein	0.90
ST6GAL1	regulates	gene	0.90
DEPRESSION	associated_with	disease	0.90
SIRT1	inhibits	protein	0.90
CCL20	regulates	protein	0.90
Alzheimer's disease	fuels	disease	0.90
NLRP3	activates	protein	0.90
SIRT1	associated_with	gene	0.90
Inflammation	regulates	process	0.90
UBIQUITIN	associated_with	protein	0.90
STROKE	associated_with	disease	0.90
STAT3	interacts_with	pathway	0.90
Cancer	contributes_to	disease	0.90
Nf-Kb	inhibits	pathway	0.90
NEUROINFLAMMATION	activates	gene	0.90
INFLAMMATION	regulates	gene	0.90
NEURON	inhibits	cell_type	0.86
NEURON	interacts_with	cell_type	0.86
NEURON	activates	cell_type	0.86

Incoming (909)

Source	Relation	Type	Str
ASTROCYTES	associated_with	cell_type	1.00
AKT	associated_with	gene	1.00
MTOR	associated_with	gene	1.00
CASP3	associated_with	gene	1.00
AMPK	associated_with	gene	1.00
IL-6	associated_with	gene	1.00
IL-1B	associated_with	gene	1.00
NEURODEGENERATION	associated_with	gene	1.00
ERK	associated_with	gene	1.00
AMYLOID	associated_with	protein	1.00
MICROGLIA	associated_with	cell_type	1.00
NF-KB	activates	gene	1.00
ALZHEIMER'S DISEASE	associated_with	disease	1.00
TNF	activates	gene	1.00
TNF-Α	activates	gene	1.00
APOPTOSIS	associated_with	gene	1.00
TNF	activates	gene	1.00
h-35cc314907	targets	hypothesis	1.00
Inflammation	regulates	disease	1.00
CYTOKINES	activates	gene	1.00
Inflammation	activates	disease	1.00
NF-KB	regulates	gene	1.00
ABLIM1	activates	protein	0.95
MACROPHAGES	activates	cell_type	0.95
B CELLS	activates	cell_type	0.95
ALS	associated_with	disease	0.90
P38	regulates	gene	0.90
TLR4	activates	protein	0.90
SIRT1	inhibits	protein	0.90
hesperetin	inhibits	drug	0.90
IL-1β	activates	protein	0.90
ginseng root extract	inhibits	drug	0.90
TNIP1	inhibits	protein	0.90
Cancer	activates	disease	0.90
CANCER	activates	gene	0.90
INFLAMMATION	regulates	gene	0.90
NEUROINFLAMMATION	activates	gene	0.90
NF-KB	inhibits	gene	0.90
Neuroinflammation	activates	disease	0.90
NEURON	activates	cell_type	0.86
Curcumin	modulates	compound	0.85
Reactive Microglia	expressed_in	cell_type	0.85
Astrocytes	expressed_in	cell_type	0.85
APOE	associated_with	gene	0.82
BAX	associated_with	gene	0.82
JUN	associated_with	gene	0.82
ROS	activates	protein	0.80
HYPOXIA	activates	process	0.80
MUC1	upregulates	gene	0.80
APP	associated_with	gene	0.80

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity