gene

p4hb

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about p4hb: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

57Connections

0Hypotheses

0Analyses

50Outgoing

6Incoming

0Experiments

0Debates

No summary available yet.

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🧬 Gene Info

Gene Symbol	P4HB
Chromosome	17q25.3
Function	P4HB - Prolyl 4-Hydroxylase Subunit Beta is involved in cellular protein quality control mechanisms essential for neuronal survival.
Molecular Weight	57 kDa
UniProt ID	P07237
NCBI Gene ID	5035
Ensembl ID	ENSG00000185684
OMIM	176790
GeneCards	P4HB
Human Protein Atlas	P4HB
Associated Diseases	Als, Tumor, Cancer, Ms, Carcinoma, neurodegeneration
Databases	GeneCards HPA STRING

🔮 Predicted Structure: p4hb — AlphaFold P07237 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

P4HB Gene

gene · 636 words

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Pathway Diagram

graph TD
    P4HB["P4HB"]
    P4HB -->|"regulates"| Cardiac["Cardiac"]
    P4HB -->|"regulates"| Ms["Ms"]
    P4HB -->|"regulates"| Cardiovascular["Cardiovascular"]
    P4HB -->|"expressed in"| Tumor["Tumor"]
    P4HB -->|"expressed in"| Senescence["Senescence"]
    P4HB -->|"expressed in"| Cancer["Cancer"]
    P4HB -->|"expressed in"| Ataxia["Ataxia"]
    P4HB -->|"activates"| Diabetes["Diabetes"]
    ROS["ROS"] -->|"activates"| P4HB
    PRMT1["PRMT1"] -->|"activates"| P4HB
    RNA["RNA"] -->|"activates"| P4HB
    CYP11A1["CYP11A1"] -->|"activates"| P4HB

Outgoing (51)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:P4HB	data_in	dataset_row	0.00
Tumor	expressed_in	disease	0.65
Diabetes	activates	disease	0.65
Fibrosis	regulates	disease	0.65
Senescence	expressed_in	disease	0.65
Tumor	associated_with	disease	0.65
Ataxia	expressed_in	disease	0.65
Cancer	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Carcinoma	associated_with	disease	0.65
Als	associated_with	disease	0.65
Cancer	expressed_in	disease	0.65
Cancer	activates	disease	0.65
Cardiac	regulates	disease	0.65
Ms	regulates	disease	0.65
Cardiovascular	regulates	disease	0.65
MITOPHAGY	regulates	gene	0.60
Mitophagy	regulates	pathway	0.60
Fibroblast	therapeutic_target	cell_type	0.60
Collagen	therapeutic_target	protein	0.60
Er Stress	associated_with	pathway	0.60
APOPTOSIS	expressed_in	gene	0.60
Apoptosis	expressed_in	pathway	0.60
CANCER	associated_with	gene	0.60
Lipid Metabolism	associated_with	pathway	0.60
CANCER	expressed_in	gene	0.60
MITOCHONDRIA	regulates	gene	0.60
Ras	inhibits	protein	0.60
Epithelial	activates	cell_type	0.60
Collagen	activates	protein	0.60
Fus	interacts_with	protein	0.60
HEDGEHOG	therapeutic_target	gene	0.60
APOPTOSIS	therapeutic_target	gene	0.60
PTGS2	regulates	gene	0.60
GRB2	regulates	gene	0.60
NDP52	regulates	gene	0.60
GSK3B	regulates	gene	0.60
GOT2	regulates	gene	0.60
MT2A	associated_with	gene	0.60
TERT	expressed_in	gene	0.60
CFL1	associated_with	gene	0.60
ATM	expressed_in	gene	0.60
SOD2	associated_with	gene	0.60
CD8	associated_with	gene	0.60
APOE	associated_with	gene	0.60
TNFSF10	associated_with	gene	0.60
Rb	regulates	protein	0.60
VIMENTIN	activates	gene	0.60
Fibronectin	activates	protein	0.60
BMP4	therapeutic_target	gene	0.60

Incoming (6)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:P4HB	data_in	dataset_row	0.00
LGALS1	associated_with	gene	0.60
PRMT1	activates	gene	0.60
ROS	activates	gene	0.60
RNA	activates	gene	0.60
CYP11A1	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning p4hb in their description or question text

No additional research found