gene 2,871 words KG: TERT
Contents

TERT Gene

🧬 Gene Info
Gene SymbolTERT
Full NameTelomerase Reverse Transcriptase
Chromosome5p15.33
Functiondyskerin (DKC1): Stabilizes the complex
Primary Expressionhippocampal subgranular zone (SGZ)
Molecular Weight127 kDa
Amino Acids1132 aa
Exons16
PathwaysTelomere Dysfunction
UniProt ID[O14748](https://www.uniprot.org/uniprot/O14748)
Ensembl IDENSG00000164362
OMIM607409
GeneCardsTERT
Human Protein AtlasTERT
Reverse transcriptase activityCatalyzes addition of TTAGGG repeats to telomeres
Associated DiseasesAD, ALI, Als, AMI, cancer
Known Drugs/CompoundsTAC
InteractionsACVR2A, AGING, AKT, AKT3, AMPK, AND
KG Connections525 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (37)

Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.73
Gamma entrainment therapy to restore hippocampal-cortical sy
Score: 0.90
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76
Senescence-Activated NAD+ Depletion Rescue
Score: 0.76
Epigenetic Memory Erasure via TET2 Activation
Score: 0.74
PARP1 Inhibition Therapy
Score: 0.74
SIRT3-Mediated Mitochondrial Deacetylation Failure with PINK
Score: 0.74
Senescence-Associated Myelin Lipid Remodeling
Score: 0.73
Senescence-Induced Lipid Peroxidation Spreading
Score: 0.73
CYP46A1 Overexpression Gene Therapy
Score: 0.73
TFAM overexpression creates mitochondrial donor-recipient gr
Score: 0.73
Sleep Spindle-Synaptic Plasticity Enhancement
Score: 0.72
Astroglial Gap Junction Coordination via Connexin-43 Phospho
Score: 0.72
Purinergic Signaling Polarization Control
Score: 0.71
Circadian Glymphatic Rescue Therapy (Melatonin-focused)
Score: 0.71
HDAC3-Selective Inhibition for Clock Reset
Score: 0.71
Purinergic P2Y12 Inverse Agonist Therapy
Score: 0.70
Microglial Purinergic Reprogramming
Score: 0.70
SASP-Mediated Complement Cascade Amplification
Score: 0.70
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Related Analyses (19)

Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived

Related Experiments (1)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40

See Also (14)

AMPK (AMP-Activated Protein Kinase)
entity · KG edge: activates
Apoptosis in Neurodegeneration
entity · KG edge: activates
ABCB1 (MDR1) - ATP Binding Cassette Subfamily B Member
gene · KG edge: therapeutic_target
ACVR2A Gene
gene · KG edge: activates
ALDH1A1 Gene
gene · KG edge: therapeutic_target

Knowledge Graph (12 edges)

IDH1 therapeutic_target TERT
VEGFA therapeutic_target TERT
MDM4 therapeutic_target TERT
APOB therapeutic_target TERT
SF3B1 therapeutic_target TERT
MET therapeutic_target TERT
SMARCA4 therapeutic_target TERT
TERT therapeutic_target JUN
TERT therapeutic_target EEF1A1
TERT therapeutic_target MCL1

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