gene

IDH1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about IDH1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

388Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

1Debates

Summary

IDH1 is a gene implicated in neurodegeneration research. Key relationships include: therapeutic target, associated with, implicated in. Associated with AD, ADH, ALI. Connected to 251 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	IDH1
Full Name	Isocitrate Dehydrogenase 1 (NADP+)
Aliases	Page for IDH1 Gene, Page for IDH1 Protein
Chromosome	2q33.3
Protein Type	Enzyme
Function	IDH1 is a NADP+-dependent enzyme localized primarily in the cytosol and peroxisomes.
Molecular Weight	47 kDa
Pathways	Epigenetic
UniProt ID	O75874
NCBI Gene ID	3417
Ensembl ID	ENSG00000138449
GeneCards	IDH1
Human Protein Atlas	IDH1
Associated Diseases	AD, ADH, Aging, ALI, Als, AMI
Interactions	ADRA2A, ALDH1A2, AND, APOB, ASTROCYTE, CANCER
KG Connections	388 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: IDH1 — AlphaFold O75874 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

IDH1 Gene - Isocitrate Dehydrogenase 1

gene · 557 words

→

IDH1 Protein - Isocitrate Dehydrogenase 1

protein · 762 words

→

Pathway Diagram

flowchart TD
    IDH1["IDH1
(Isocitrate Dehydrogenase 1)"]
    
    MetabolicChanges["Metabolic
Changes"]
    AlphaKG["alpha-Ketoglutarate
Production"]
    TwoHG["2-Hydroxyglutarate
(Oncometabolite)"]
    
    Neuroinflammation["Neuroinflammation"]
    Inflammation["Systemic
Inflammation"]
    OxidativeStress["Oxidative
Stress"]
    
    Alzheimer["Alzheimer's
Disease"]
    Parkinson["Parkinson's
Disease"]
    ALS["Amyotrophic Lateral
Sclerosis"]
    MS["Multiple
Sclerosis"]
    Neurodegeneration["Neurodegeneration"]
    
    Glioma["Glioma"]
    Glioblastoma["Glioblastoma"]
    Cancer["Cancer"]
    
    TherapeuticTarget["Therapeutic
Target"]
    Biomarker["Disease
Biomarker"]
    
    IDH1 -->|"modulates"| MetabolicChanges
    IDH1 -->|"produces"| AlphaKG
    IDH1 -->|"mutation produces"| TwoHG
    
    MetabolicChanges -->|"leads to"| OxidativeStress
    TwoHG -->|"promotes"| Neuroinflammation
    
    IDH1 -->|"activates"| Neuroinflammation
    IDH1 -->|"activates"| Inflammation
    Neuroinflammation -->|"contributes to"| Neurodegeneration
    
    IDH1 -->|"activates"| Alzheimer
    IDH1 -->|"activates"| Parkinson
    IDH1 -->|"associated with"| ALS
    IDH1 -->|"associated with"| MS
    
    IDH1 -->|"associated with"| Glioma
    IDH1 -->|"associated with"| Glioblastoma
    IDH1 -->|"therapeutic target"| Cancer
    
    IDH1 -->|"serves as"| Biomarker
    IDH1 -->|"serves as"| TherapeuticTarget
    
    style IDH1 fill:#006494
    style AlphaKG fill:#1b5e20
    style TwoHG fill:#ef5350
    style Neuroinflammation fill:#ef5350
    style Inflammation fill:#ef5350
    style OxidativeStress fill:#ef5350
    style Neurodegeneration fill:#5d4400
    style Alzheimer fill:#5d4400
    style Parkinson fill:#5d4400
    style ALS fill:#5d4400
    style MS fill:#5d4400
    style TherapeuticTarget fill:#1b5e20
    style Biomarker fill:#4a1a6b

Outgoing (278)

Target	Relation	Type	Str
Isocitrate to α-Ketoglutarate Conversion	catalyzes	process	0.98
ASTROCYTOMA	associated_with	entity	0.98
OLIGODENDROGLIOMA	associated_with	entity	0.98
GLIOBLASTOMA	associated_with	entity	0.98
GLIOMA	associated_with	entity	0.98
Isocitrate To α-Ketoglutarate Conversion	catalyzes	process	0.95
ENZYMATIC ACTIVITY	regulates	entity	0.95
Isocitrate	associated_with	compound	0.95
Astrocytoma	associated_with	disease	0.95
Oligodendroglioma	associated_with	disease	0.95
ALPHA-KETOGLUTARATE	associated_with	entity	0.95
Nadp+-Dependent Isocitrate Dehydrogenase	involved_in	enzyme	0.92
GLIOMA	mutated_in	disease	0.90
BRAIN TUMOURS	associated_with	entity	0.90
gliomas	associated_with	disease	0.90
alpha-KG-dependent dioxygenases	inhibits	enzyme	0.90
alpha-ketoglutarate	catalyzes	entity	0.90
Secondary Glioblastoma	associated_with	disease	0.90
NADPH	catalyzes	entity	0.90
NADH	associated_with	entity	0.90
NADPH	associated_with	entity	0.90
glioma prognosis	associated_with	phenotype	0.85
ORGAN PHYSIOLOGY	regulates	entity	0.85
gene expression	associated_with	process	0.85
IDH2	interacts_with	entity	0.85
REDOX BALANCE	associated_with	entity	0.85
Gene Expression	regulates	process	0.85
Patient Survival	protects_against	phenotype	0.85
PSAT1	upregulates	gene	0.80
KDM4C	upregulates	gene	0.80
KDM4B	upregulates	gene	0.80
KDM4A	upregulates	gene	0.80
serine biosynthesis	activates	biological_process	0.80
malignancy	contributes_to	phenotype	0.80
PHGDH	upregulates	gene	0.80
Metabolic Rewiring	involved_in	process	0.80
NEURODEGENERATION	associated_with	entity	0.80
MTOR Pathway Activity	associated_with	process	0.75
mTOR	activates	protein	0.75
Neurodegeneration	contributes_to	disease	0.75
Carcinoma	therapeutic_target	disease	0.75
Tumor	therapeutic_target	disease	0.75
Cancer	therapeutic_target	disease	0.75
MTOR	activates	protein	0.75
GENES	therapeutic_target	gene	0.70
DNA	therapeutic_target	gene	0.70
metabolic changes	regulates	process	0.70
glioblastoma	associated_with	disease	0.70
Epigenetic	associated_with	pathway	0.70
Neurodegeneration	activates	disease	0.65

Incoming (110)

Source	Relation	Type	Str
JUN	therapeutic_target	gene	0.60
BRAF	associated_with	gene	0.60
TERT	associated_with	gene	0.60
FUBP1	associated_with	gene	0.60
H3F3A	associated_with	gene	0.60
JUN	biomarker_for	gene	0.60
KCNH2	therapeutic_target	gene	0.60
TP53	therapeutic_target	gene	0.60
CALM1	therapeutic_target	gene	0.60
HRAS	therapeutic_target	gene	0.60
IL1B	therapeutic_target	gene	0.60
MDH1	activates	gene	0.60
NADH	regulates	gene	0.60
AND	therapeutic_target	gene	0.60
CIRCADIAN RHYTHM	therapeutic_target	gene	0.60
ACHE	therapeutic_target	gene	0.60
CDK4	associated_with	gene	0.60
TEAD1	therapeutic_target	gene	0.60
EGFR	associated_with	gene	0.60
FGFR3	associated_with	gene	0.60
NF1	associated_with	gene	0.60
LGALS3	expressed_in	gene	0.60
PIK3CA	associated_with	gene	0.60
IDH2	inhibits	gene	0.60
EEF1A1	inhibits	gene	0.60
MDM4	inhibits	gene	0.60
JUN	inhibits	gene	0.60
MET	inhibits	gene	0.60
MCL1	inhibits	gene	0.60
VEGFA	inhibits	gene	0.60
SMARCA4	inhibits	gene	0.60
SF3B1	inhibits	gene	0.60
APOB	inhibits	gene	0.60
TERT	inhibits	gene	0.60
IDH2	associated_with	gene	0.60
OVERVIEW	biomarker_for	gene	0.60
MTOR	activates	gene	0.60
VHL	activates	gene	0.60
G6PD	activates	gene	0.60
GENES	therapeutic_target	gene	0.60
GENES	associated_with	gene	0.60
DNA	inhibits	gene	0.60
GENES	inhibits	gene	0.60
P53	inhibits	gene	0.60
CANCER	inhibits	gene	0.60
NAD	regulates	gene	0.60
NEURODEGENERATION	regulates	gene	0.60
CANCER	associated_with	gene	0.60
NEURODEGENERATION	biomarker_for	gene	0.60
CANCER	biomarker_for	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

What mechanisms explain how IDH1/IDH2 mutations with reduced enzymatic activity

neurodegeneration | 2026-04-13 | 0 hypotheses

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

The abstract shows that IDH mutations reduce protein enzymatic activity yet para

closed · Rounds: 4 · Score: 0.95 · 2026-04-16