Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about SENESCENCE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | SENESCENCE |
| Key Genes/Proteins | ABCA1, AKT, ALPHA-SYNUCLEIN, AMYLOID |
| Related Diseases | ALZHEIMER, ANGIOGENESIS |
Knowledge base pages for this entity
graph TD
SENESCENCE["SENESCENCE"] -->|"contributes to"| TUMOR["TUMOR"]
SENESCENCE["SENESCENCE"] -->|"causes"| STING["STING"]
SENESCENCE["SENESCENCE"] -->|"expressed in"| T_CELL["T CELL"]
SENESCENCE["SENESCENCE"] -->|"expressed in"| T_CELLS["T CELLS"]
SENESCENCE["SENESCENCE"] -->|"associated"| T_CELL_1["T CELL"]
SENESCENCE["SENESCENCE"] -->|"associated"| T_CELLS_2["T CELLS"]
ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"associated"| SENESCENCE["SENESCENCE"]
NEURODEGENERATION["NEURODEGENERATION"] -->|"associated"| SENESCENCE["SENESCENCE"]
PARKINSON_S_DISEASE["PARKINSON'S DISEASE"] -->|"associated"| SENESCENCE["SENESCENCE"]
NEUROINFLAMMATION["NEUROINFLAMMATION"] -->|"associated"| SENESCENCE["SENESCENCE"]
style SENESCENCE fill:#5d4400,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Alzheimer | associated_with | disease | 1.00 |
| Oxidative Stress | associated_with | pathway | 1.00 |
| Cell Cycle | associated_with | pathway | 1.00 |
| Autophagy | activates | pathway | 1.00 |
| Cell Cycle | regulates | pathway | 1.00 |
| Oxidative Stress | activates | pathway | 1.00 |
| Apoptosis | activates | pathway | 1.00 |
| Autophagy | regulates | pathway | 1.00 |
| Telomere | associated_with | pathway | 1.00 |
| Inflammation | associated_with | disease | 1.00 |
| Apoptosis | regulates | pathway | 1.00 |
| Autophagy | associated_with | pathway | 1.00 |
| Dna Repair | regulates | pathway | 1.00 |
| Epigenetic | associated_with | pathway | 1.00 |
| Nf-Κb | activates | pathway | 1.00 |
| Immune Response | activates | pathway | 1.00 |
| Differentiation | activates | pathway | 1.00 |
| Cell Cycle | activates | pathway | 1.00 |
| Epigenetic | activates | pathway | 1.00 |
| Cellular Aging | involved_in | process | 0.95 |
| aging | promotes | process | 0.95 |
| SASP | causes | process | 0.95 |
| Epigenetic | inhibits | pathway | 0.95 |
| Aging | contributes_to | process | 0.95 |
| hypersecretory state | causes | process | 0.95 |
| cell-cycle arrest | causes | process | 0.95 |
| chronic kidney disease | associated_with | disease | 0.95 |
| Inflammation | therapeutic_target | disease | 0.95 |
| kidney aging | regulates | process | 0.92 |
| Leukemia Cell Resistance | associated_with | phenotype | 0.90 |
| Senescence-Associated Secretory Phenotype | mediates | phenotype | 0.90 |
| cancer | associated_with | disease | 0.90 |
| Cell Proliferation | inhibits | process | 0.90 |
| Cellular Damage | causes | phenotype | 0.90 |
| NEUROINFLAMMATION | associated_with | entity | 0.90 |
| Stem Cell | inhibits | pathway | 0.90 |
| Pi3K/Akt | activates | pathway | 0.90 |
| Apoptosis | inhibits | pathway | 0.90 |
| Stem Cell | associated_with | pathway | 0.90 |
| Epigenetic | regulates | pathway | 0.90 |
| Mtor | activates | pathway | 0.90 |
| aging | downstream_of | process | 0.88 |
| cancer | prevents | disease | 0.87 |
| Endothelial Cell Dysfunction | contributes_to | phenotype | 0.85 |
| senescence-associated disease | causes | disease | 0.85 |
| chronic disease | associated_with | disease | 0.85 |
| adaptive responses | inhibits | process | 0.85 |
| cardiovascular diseases | causes | disease | 0.85 |
| skin photoaging | associated_with | disease | 0.85 |
| Alzheimer's Disease | associated_with | disease | 0.85 |
| Source | Relation | Type | Str |
|---|---|---|---|
| NEURODEGENERATIVE DISEASES | associated_with | gene | 1.00 |
| AGING | therapeutic_target | gene | 1.00 |
| Als | activates | disease | 1.00 |
| AUTOPHAGY | associated_with | gene | 1.00 |
| MITOCHONDRIAL DYSFUNCTION | associated_with | gene | 1.00 |
| Cancer | regulates | disease | 1.00 |
| OXIDATIVE STRESS | associated_with | gene | 1.00 |
| MITOCHONDRIA | regulates | gene | 1.00 |
| CANCER | implicated_in | gene | 1.00 |
| Inflammation | activates | disease | 1.00 |
| AUTOPHAGY | regulates | gene | 1.00 |
| P53 | regulates | gene | 1.00 |
| Aging | associated_with | disease | 1.00 |
| ALZHEIMER'S DISEASE | associated_with | gene | 1.00 |
| INFLAMMATION | regulates | gene | 1.00 |
| Cardiovascular | associated_with | disease | 1.00 |
| INFLAMMATION | therapeutic_target | gene | 1.00 |
| Neurodegeneration | associated_with | disease | 1.00 |
| Neurodegeneration | activates | disease | 1.00 |
| AGING | inhibits | gene | 1.00 |
| ROS | activates | gene | 1.00 |
| CANCER | inhibits | gene | 1.00 |
| NEURODEGENERATION | associated_with | gene | 1.00 |
| INFLAMMATION | activates | gene | 1.00 |
| P53 | inhibits | gene | 1.00 |
| Tumor | activates | disease | 1.00 |
| AGING | activates | gene | 1.00 |
| Cancer | implicated_in | disease | 1.00 |
| INFLAMMATION | associated_with | gene | 1.00 |
| INFLAMMATION | inhibits | gene | 1.00 |
| P53 | activates | gene | 1.00 |
| CANCER | associated_with | gene | 1.00 |
| AMPK | activates | gene | 1.00 |
| SIRT1 | activates | gene | 1.00 |
| Aging | inhibits | disease | 1.00 |
| Tumor | associated_with | disease | 1.00 |
| Als | regulates | disease | 1.00 |
| Aging | regulates | disease | 1.00 |
| Cancer | associated_with | disease | 1.00 |
| GENES | associated_with | gene | 1.00 |
| IL-6 | activates | gene | 1.00 |
| CGAS | activates | gene | 1.00 |
| CANCER | therapeutic_target | gene | 1.00 |
| ALZHEIMER | associated_with | gene | 1.00 |
| AGING | associated_with | gene | 1.00 |
| Alzheimer | associated_with | disease | 1.00 |
| NEURODEGENERATION | activates | gene | 1.00 |
| APOPTOSIS | activates | gene | 1.00 |
| CYTOKINES | activates | gene | 1.00 |
| Cancer | activates | disease | 1.00 |
Hypotheses where this entity is a therapeutic target
Scientific analyses that reference this entity
neurodegeneration | 2026-04-04 | 7 hypotheses Top: 1.000
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| TREM2 KO amyloid pathology study | validation | Alzheimers Disease | 0.750 | 0.00 | Mouse (5xFAD/TREM2-/-) | completed | N/A |
| TREM2 KO amyloid pathology study | validation | Alzheimers Disease | 0.750 | 0.00 | Mouse (5xFAD/TREM2-/-) | completed | N/A |
| TREM2 KO amyloid pathology study | validation | Alzheimers Disease | 0.750 | 0.00 | Mouse (5xFAD/TREM2-/-) | in_progress | N/A |
| TREM2 KO amyloid pathology study | validation | Alzheimers Disease | 0.750 | 0.00 | Mouse (5xFAD/TREM2-/-) | completed | N/A |
| TREM2 KO amyloid pathology study | validation | Alzheimers Disease | 0.750 | 0.00 | Mouse (5xFAD/TREM2-/-) | in_progress | N/A |
| TREM2 KO amyloid pathology study | validation | Alzheimers Disease | 0.750 | 0.00 | Mouse (5xFAD/TREM2-/-) | completed | N/A |
| E2F coordination of G2/M transcriptional program | exploratory | 0.750 | 0.00 | endocycling mammalian cells | proposed | N/A |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Microglia-Mediated Neuroinflammation: A Potential Target for the Treatment of Ca [PMID:35642214] | Wang M, Pan W, Xu Y, Zhang J, Wan J, Jia | J Inflamm Res | 2022 | 1 |
| TREM2, microglia, and Alzheimer's disease. [PMID:33516818] | Qin Q, Teng Z, Liu C, Li Q, Yin Y, Tang | Mech Ageing Dev | 2021 | 1 |
| Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2- [PMID:31932797] | Zhou Y, Song WM, Andhey PS, Swain A, Lev | Nat Med | 2020 | 1 |
| TREM2 Maintains Microglial Metabolic Fitness in Alzheimer's Disease. [PMID:28802038] | Ulland TK, Song WM, Huang SC, Ulrich JD, | Cell | 2017 | 1 |
| The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Mic [PMID:28930663] | Krasemann S, Madore C, Cialic R, Baufeld | Immunity | 2017 | 1 |
| Precision Neurodegeneration: Integrating Molecular Mechanisms, Biomarkers, and T [PMID:41833042] | ["Lyu G", "Li D"] | CNS & neurological disorders d | 2026 | 0 |
| Emerging pathological mechanisms of Alzheimer's disease pathogenesis: from neuro [PMID:41858793] | ["Wang R", "Feng Y", "Zhou Z", "Jiang J" | Frontiers in aging neuroscienc | 2026 | 0 |
| Human CSF proteogenomics links genetic variation to neurodegenerative disease pr [PMID:41757182] | ["Puerta R", "Garc\u00eda-Gonz\u00e1lez | medRxiv : the preprint server | 2026 | 0 |
| PLCG2 signaling and genetic resilience in Alzheimer's disease. [PMID:41888907] | Tsai AP, Martin AK, Mi A, Yeh AE, Ramire | Molecular neurodegeneration | 2026 | 0 |
| PLCG2 signaling and genetic resilience in Alzheimer's disease. [PMID:41888907] | Tsai AP, Martin AK, Mi A, Yeh AE, Ramire | Mol Neurodegener | 2026 | 0 |
| TREM2 deficiency delays postnatal microglial maturation and synaptic pruning, le [PMID:41930604] | Yang HC, Deng YS, Zhang J, Zhang T, Song | J Alzheimers Dis | 2026 | 0 |
| Investigating the Potential of Gene Editing Technologies in Enhancing Stem Cell [PMID:41926312] | ["Mehrabadi S"] | Current aging science | 2026 | 0 |
| TREM2 in neurodegeneration and diseases. [PMID:41792456] | ["Abdulkhaliq A", "Alasiri G", "Kim B", | Molecular psychiatry | 2026 | 0 |
| Berbamine hydrochloride as a brain penetrant galectin 3 inhibitor in a model of [PMID:41772384] | ["Siew J", "Lee C", "Chen H", "Lin H", " | Brain : a journal of neurology | 2026 | 0 |
| The microglial TREM2 receptor programs hippocampal development in a mouse model [PMID:41887542] | Ahmed S, Bowers C, Munoz-Martin J, Jamwa | Brain, behavior, and immunity | 2026 | 0 |
| Molecular mechanism of Alzheimer's disease using integrated multi-omics. [PMID:41907842] | Alhusaini M, Mussa BM, Ilce BY, Alhaj H, | Frontiers in aging neuroscienc | 2026 | 0 |
| Oligodendrocyte precursor cells-microglia crosstalk via BMP4 drives microglial n [PMID:41881962] | Baek S, Jang J, Yeo S, Jung HJ, Choe Y | Signal transduction and target | 2026 | 0 |
| Phagocytes as plaque catalysts: Human macrophages generate seeding-competent Aβ4 [PMID:41770935] | ["Konstantoulea K", "Ramakers M", "Borri | Proceedings of the National Ac | 2026 | 0 |
| Microglia, Trem2, and Neurodegeneration. [PMID:38769824] | Shi Q, Gutierrez RA, Bhat MA | Neuroscientist | 2025 | 0 |
| Microglia, Trem2, and Neurodegeneration. [PMID:38769824] | Shi Q, Gutierrez RA, Bhat MA | The Neuroscientist : a review | 2025 | 0 |
Multi-agent debates referencing this entity
closed · Rounds: 4 · Score: 0.81 · 2026-04-23
closed · Rounds: 4 · Score: 0.75 · 2026-04-16
closed · Rounds: 3 · Score: 0.95 · 2026-04-04