Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about PD1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | PD1 |
| Key Genes/Proteins | APP, CCR2, CD8, CLOCK, CTLA4, CXCL9 |
| Related Diseases | CANCER, glioblastoma |
| Related Pathways | apoptosis pathway |
| Linked Hypotheses | 1 hypotheses |
Knowledge base pages for this entity
graph TD
PD1[PD1]
PD1 -->|expressed in| T_cells[T cells]
PD1 -->|inhibits| TUMOR_GROWTH[TUMOR GROWTH]
PD1 -->|inhibits| CANCER[CANCER]
PD1 -->|inhibits| PPP1[PPP1]
PD1 -->|causes| TRAIL[TRAIL]
PD1 -->|inhibits| PTEN[PTEN]
PD1 -->|inhibits| STK11[STK11]
PD1 -->|participates in| apoptosis_pathway[apoptosis pathway]
PD1 -->|inhibits| glioblastoma[glioblastoma]
MICROGLIA[MICROGLIA] -->|produces| PD1
IFNG[IFNG] -->|causes| PD1
CLOCK[CLOCK] -->|inhibits| PD1
GBM[GBM] -->|inhibits| PD1
LOX[LOX] -->|inhibits| PD1
OLFML3[OLFML3] -->|inhibits| PD1
IGSF8[IGSF8] -->|inhibits| PD1
NRF2[NRF2] -->|activates| PD1| Target | Relation | Type | Str |
|---|---|---|---|
| T cells | expressed_in | cell_type | 0.70 |
| CANCER | inhibits | disease | 0.65 |
| TUMOR GROWTH | inhibits | phenotype | 0.65 |
| PPP1 | inhibits | protein | 0.64 |
| glioblastoma | inhibits | disease | 0.60 |
| macrophages | expressed_in | cell_type | 0.60 |
| microglia | expressed_in | cell_type | 0.60 |
| apoptosis pathway | participates_in | pathway | 0.60 |
| STK11 | inhibits | gene | 0.60 |
| TRAIL | causes | gene | 0.60 |
| TRAIL | activates | gene | 0.60 |
| PTEN | inhibits | gene | 0.60 |
| TNF | protects_against | gene | 0.55 |
| oxidative stress response | participates_in | pathway | 0.55 |
| multiple sclerosis | activates | disease | 0.55 |
| DAM microglia | expressed_in | cell_type | 0.55 |
| stem cells | expressed_in | cell_type | 0.55 |
| oligodendrocytes | expressed_in | cell_type | 0.55 |
| OLIGODENDROCYTE | associated_with | cell_type | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| MICROGLIA | inhibits | cell_type | 0.65 |
| MICROGLIA | produces | cell_type | 0.65 |
| IFNG | activates | gene | 0.60 |
| CLOCK | inhibits | gene | 0.60 |
| GBM | inhibits | gene | 0.60 |
| LOX | inhibits | gene | 0.60 |
| OLFML3 | inhibits | gene | 0.60 |
| IGSF8 | inhibits | gene | 0.60 |
| MICROGLIA | synergizes_with | cell_type | 0.60 |
| IFNG | causes | gene | 0.60 |
| CD8 | activates | gene | 0.60 |
| CCR2 | expressed_in | gene | 0.60 |
| CD8 | expressed_in | gene | 0.60 |
| CXCR3 | expressed_in | gene | 0.60 |
| MYC | activates | gene | 0.60 |
| CTLA4 | inhibits | gene | 0.60 |
| KRAS | inhibits | gene | 0.60 |
| LKB1 | inhibits | gene | 0.60 |
| CXCL9 | expressed_in | gene | 0.60 |
| NRF2 | activates | gene | 0.60 |
| GPR37 | activates | gene | 0.55 |
| GPR37 | regulates | gene | 0.55 |
| GPR37 | targets | gene | 0.55 |
| GPR37 | interacts_with | gene | 0.55 |
| APP | activates | gene | 0.55 |
| FINGOLIMOD | associated_with | drug | 0.50 |
| NATALIZUMAB | associated_with | drug | 0.50 |
| CANCER | associated_with | disease | 0.45 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| SMPD1 (Acid Sphingomyelinase) Inhibition for Ceramide Reduct | 0.732 | neurodegeneration | How do sphingomyelin/ceramide ratios spe |
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Pathogenic Variants and Olipudase Alfa Treatment of Patients With Acid Sphingomy [PMID:41692468] | ["Hsu-Heng Lin", "Hui-An Chen", "Shyh-Je | Molecular genetics & genom | 2026 | 0 |
| Multi-omics analysis identifies SMPD1 as a key contributor in sphingolipid pathw [PMID:41428198] | ["Aron Park", "Baeki E Kang", "Eun-Ju Ji | Genes & genomics | 2026 | 0 |
| A multi-dimensional bioinformatic dissection of the molecular mechanisms in high [PMID:41191606] | Yu X MD, Lei J MSc, Du X MSc, He Y MSc, | Int J Surg | 2026 | 0 |
| Plasma metabolites may inhibit childhood obesity by regulating ferroptosis throu [PMID:41249848] | Wang JG, Pan XH, Li Y | Int J Obes (Lond) | 2026 | 0 |
| Multi-omics analysis identifies SMPD1 as a key contributor in sphingolipid pathw [PMID:41428198] | Park A, Kang BE, Jin EJ, Kim HJ, Lee CW | Genes Genomics | 2026 | 0 |
| AXL Promotes Ischemic Myelin Repair Through Alleviating Myelin Debris Deposition [PMID:41524160] | Jia J, Gan Y, Li J, Li L, Meng H et al. | Adv Sci (Weinh) | 2026 | 0 |
| Pathogenic Variants and Olipudase Alfa Treatment of Patients With Acid Sphingomy [PMID:41692468] | Lin HH, Chen HA, Lin SJ, Hsu RH, Lee NC | Mol Genet Genomic Med | 2026 | 0 |
| AXL Promotes Ischemic Myelin Repair Through Alleviating Myelin Debris Deposition [PMID:41524160] | Jia J, Gan Y, Li J, Li L, Meng H, Sun M, | Advanced science (Weinheim, Ba | 2026 | 0 |
| A multi-dimensional bioinformatic dissection of the molecular mechanisms in high [PMID:41191606] | Yu X, Lei J, Du X, He Y, Peng W, Yang R, | International journal of surge | 2026 | 0 |
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning PD1 in their description or question text
No additional research found