gene

MAP3K7

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MAP3K7: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

75Connections

0Hypotheses

0Analyses

47Outgoing

28Incoming

0Experiments

0Debates

Summary

MAP3K7 is a gene implicated in neurodegeneration research. Key relationships include: activates, inhibits, implicated in. Associated with Als, Cancer, Infection. Connected to 72 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	MAP3K7
Full Name	Mitogen-Activated Protein Kinase Kinase Kinase 7
Chromosome	6q15
Protein Family	MAP3K family, STE20-like kinases
Function	MAP3K7 encodes TAK1 (Transforming Growth Factor Beta-Activated Kinase 1), a serine/threonine kinase that serves as a central mediator of inflammatory, stress-activated, and developmental signaling pat
Primary Expression	Ubiquitous (brain, immune, periphery)
Molecular Weight	67 kDa
Amino Acids	606 aa
Pathways	TGF-β, NF-κB
UniProt ID	[O43318](https://www.uniprot.org/uniprot/O43318)
Ensembl ID	ENSG00000171081
OMIM	602614
GeneCards	MAP3K7
Human Protein Atlas	MAP3K7
IKK complex	TAK1 phosphorylates IKKβ, leading to IκB degradation and NF-κB nuclear translocation
Associated Diseases	neurodegeneration
Interactions	AMPK, AND, AUTOPHAGY, AXIN, BECN1, CANCER
KG Connections	75 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

MAP3K7 Gene

gene · 1811 words

→

Pathway Diagram

graph TD
    MAP3K7["MAP3K7"]
    Cancer{"Cancer"}
    MAP3K7 -->|"activates"| Cancer
    Als{"Als"}
    MAP3K7 -->|"inhibits"| Als
    MAP3K7 -->|"inhibits"| Cancer
    Tumor{"Tumor"}
    MAP3K7 -->|"inhibits"| Tumor
    TLR4["TLR4"]
    MAP3K7 -->|"activates"| TLR4
    RELA["RELA"]
    MAP3K7 -->|"activates"| RELA
    TAK1["TAK1"]
    MAP3K7 -->|"activates"| TAK1
    IKBKB["IKBKB"]
    MAP3K7 -->|"activates"| IKBKB
    IL6["IL6"]
    MAP3K7 -->|"activates"| IL6
    NFKB["NFKB"]
    MAP3K7 -->|"activates"| NFKB
    LC3["LC3"]
    MAP3K7 -->|"activates"| LC3
    Nf_Kb(["Nf-Kb"])
    MAP3K7 -->|"activates"| Nf_Kb
    P38["P38"]
    P38 -->|"activates"| MAP3K7
    MAP1LC3["MAP1LC3"]
    MAP1LC3 -->|"activates"| MAP3K7
    IL1B["IL1B"]
    IL1B -->|"activates"| MAP3K7
    PRDX1["PRDX1"]
    PRDX1 -->|"activates"| MAP3K7
    TRAF6["TRAF6"]
    TRAF6 -->|"activates"| MAP3K7
    CHUK["CHUK"]
    CHUK -->|"activates"| MAP3K7
    PRDX6["PRDX6"]
    PRDX6 -->|"activates"| MAP3K7
    MAPK14["MAPK14"]
    MAPK14 -->|"activates"| MAP3K7
    BECN1["BECN1"]
    BECN1 -->|"activates"| MAP3K7
    TNF["TNF"]
    TNF -->|"activates"| MAP3K7
    ECSIT["ECSIT"]
    ECSIT -->|"activates"| MAP3K7
    TLR4 -->|"activates"| MAP3K7
    style MAP3K7 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (47)

Target	Relation	Type	Str
SQSTM1	phosphorylates	protein	0.85
TAK1	activates	gene	0.70
Cancer	inhibits	disease	0.65
Tumor	activates	disease	0.65
Als	inhibits	disease	0.65
Als	activates	disease	0.65
Tumor	inhibits	disease	0.65
Infection	activates	disease	0.65
Cancer	activates	disease	0.65
NFKB	activates	gene	0.60
Nf-Kb	activates	pathway	0.60
Autophagy	activates	pathway	0.60
Mapk	activates	pathway	0.60
NF-KB	activates	gene	0.60
MAP1LC3	activates	gene	0.60
Unfolded Protein Response	inhibits	pathway	0.60
Mapk	inhibits	pathway	0.60
AMPK	activates	gene	0.60
AXIN	activates	gene	0.60
CANCER	activates	gene	0.60
Invasion	activates	pathway	0.60
AND	activates	gene	0.60
AUTOPHAGY	activates	gene	0.60
TLR4	activates	gene	0.60
RELA	activates	gene	0.60
IKBKB	activates	gene	0.60
IL6	activates	gene	0.60
LC3	activates	gene	0.60
IL1B	activates	gene	0.60
BECN1	activates	gene	0.60
TRAF6	activates	gene	0.60
ECSIT	activates	gene	0.60
P38	activates	gene	0.60
CHUK	activates	gene	0.60
PRDX6	activates	gene	0.60
PRDX1	activates	gene	0.60
ERN1	inhibits	gene	0.60
PP2A	activates	gene	0.60
TAK1	inhibits	gene	0.60
KEAP1	activates	gene	0.60
SQSTM1	activates	gene	0.60
NRF2	activates	gene	0.60
NFE2L2	activates	gene	0.60
TFE3	activates	gene	0.60
P62	activates	gene	0.60
STK11	activates	gene	0.60
UBIQUITIN	activates	gene	0.60

Incoming (28)

Source	Relation	Type	Str
P38	activates	gene	0.60
IL1B	activates	gene	0.60
PRDX1	activates	gene	0.60
TRAF6	activates	gene	0.60
CHUK	activates	gene	0.60
PRDX6	activates	gene	0.60
MAPK14	activates	gene	0.60
BECN1	activates	gene	0.60
TNF	activates	gene	0.60
ECSIT	activates	gene	0.60
TLR4	activates	gene	0.60
UBIQUITIN	activates	gene	0.60
MAPK8	inhibits	gene	0.60
JUN	inhibits	gene	0.60
TFEB	activates	gene	0.60
TAK1	activates	gene	0.60
RELA	activates	gene	0.60
IL6	activates	gene	0.60
LC3	activates	gene	0.60
IKBKB	activates	gene	0.60
MAP1LC3	activates	gene	0.60
CANCER	activates	gene	0.60
AUTOPHAGY	activates	gene	0.60
KRAS	inhibits	gene	0.60
CANCER	inhibits	gene	0.60
ROS	activates	gene	0.60
NFKB	activates	gene	0.60
NF-KB	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning MAP3K7 in their description or question text

No additional research found