gene

AURKB

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about AURKB: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

86Connections

0Hypotheses

0Analyses

50Outgoing

30Incoming

0Experiments

0Debates

Summary

AURKB is a gene implicated in neurodegeneration research. Key relationships include: activates, implicated in. Associated with Als, Cancer, Ms. Connected to 10 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	Aurora Kinase B
Aliases	AURKB
Chromosome	17p13.1
Function	is a chromosome passenger complex protein essential for mitosis and cytokinesis.
Subcellular Localization	. The CPC, composed of Aurora B, survivin (BIRC5), INCENP, and Borealin, targets Aurora B to the inner centromere during
Gene Type	Protein Coding
UniProt ID	Q96GD4
NCBI Gene ID	9212
Ensembl ID	ENSG00000178999
Associated Diseases	neurodegeneration
Known Drugs/Compounds	rapamycin
Interactions	ACTB, AMPK, AND, ASPM, ATG, CALM1
KG Connections	86 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: AURKB — AlphaFold Q96GD4 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

AURKB Gene

gene · 672 words

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Pathway Diagram

graph TD
    AURKB["AURKB"]
    Als{"Als"}
    AURKB -->|"activates"| Als
    Senescence{"Senescence"}
    AURKB -->|"activates"| Senescence
    Ms{"Ms"}
    AURKB -->|"activates"| Ms
    Cancer{"Cancer"}
    AURKB -->|"activates"| Cancer
    Tumor{"Tumor"}
    AURKB -->|"activates"| Tumor
    AND["AND"]
    AURKB -->|"activates"| AND
    neurodegeneration["neurodegeneration"]
    AURKB -->|"implicated in"| neurodegeneration
    GENES["GENES"]
    GENES -->|"activates"| AURKB
    MYC["MYC"]
    MYC -->|"activates"| AURKB
    CANCER["CANCER"]
    CANCER -->|"activates"| AURKB
    H2AX["H2AX"]
    H2AX -->|"activates"| AURKB
    style AURKB fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (56)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:AURKB	data_in	dataset_row	0.00
ds-83b31ef18d49	provides_data_for	dataset	1.00
Senescence	activates	disease	0.65
Ms	activates	disease	0.65
Als	activates	disease	0.65
Cancer	activates	disease	0.65
Tumor	activates	disease	0.65
Leukemia	activates	disease	0.65
RANK	therapeutic_target	gene	0.60
NEFH	associated_with	gene	0.60
KIF5B	interacts_with	gene	0.60
CDC42	associated_with	gene	0.60
PVALB	interacts_with	gene	0.60
SST	interacts_with	gene	0.60
GAP43	associated_with	gene	0.60
RANK	interacts_with	gene	0.60
ULK1	regulates	gene	0.60
LC3	activates	gene	0.60
ULK1	phosphorylates	gene	0.60
neuroinflammation	activates	disease	0.60
ULK1	inhibits	gene	0.60
AND	regulates	gene	0.60
FBXW7	regulates	gene	0.60
MYC	activates	gene	0.60
senescence	participates_in	pathway	0.60
TPR	associated_with	gene	0.60
GFP	activates	gene	0.60
LC3B	activates	gene	0.60
LKB1	activates	gene	0.60
MTORC1	activates	gene	0.60
autophagy pathway	participates_in	pathway	0.60
ubiquitin-proteasome	participates_in	pathway	0.60
DNA	activates	gene	0.60
MKI67	associated_with	gene	0.60
NEFL	associated_with	gene	0.60
MKI67	interacts_with	gene	0.60
AND	interacts_with	gene	0.60
HUB GENES	associated_with	gene	0.60
microglia	expressed_in	cell_type	0.60
CALM1	associated_with	gene	0.60
KIF15	associated_with	gene	0.60
KIF5B	associated_with	gene	0.60
PVALB	associated_with	gene	0.60
SST	associated_with	gene	0.60
CDK1	activates	gene	0.60
DDB1	activates	gene	0.60
GAPDH	activates	gene	0.60
GLB1	activates	gene	0.60
MAP1LC3B	activates	gene	0.60
MTOR	activates	gene	0.60

Incoming (30)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:AURKB	data_in	dataset_row	0.00
ds-83b31ef18d49	data_in	dataset	1.00
KIF15	associated_with	gene	0.60
NEFL	associated_with	gene	0.60
GENES	associated_with	gene	0.60
MYC	activates	gene	0.60
H2AX	activates	gene	0.60
TPR	associated_with	gene	0.60
CDC42	associated_with	gene	0.60
GAP43	associated_with	gene	0.60
CALM1	interacts_with	gene	0.60
KIF5B	interacts_with	gene	0.60
SST	interacts_with	gene	0.60
PVALB	interacts_with	gene	0.60
AMPK	regulates	gene	0.60
AMPK	phosphorylates	gene	0.60
AMPK	inhibits	gene	0.60
rapamycin	targets	drug	0.60
GENES	activates	gene	0.60
CANCER	activates	gene	0.60
ACTB	activates	gene	0.60
AMPK	activates	gene	0.60
ATG	activates	gene	0.60
ASPM	interacts_with	protein	0.50
KIF5B	associated_with	gene	0.50
ASPM	associated_with	protein	0.50
NEFH	associated_with	gene	0.50
PVALB	associated_with	gene	0.50
CALM1	associated_with	gene	0.50
CDC42	interacts_with	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning AURKB in their description or question text

No additional research found