disease

MULTIPLE SCLEROSIS

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MULTIPLE SCLEROSIS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

2401Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

No summary available yet.

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Disease Info

Associated Genes	AB, ACHE, AD, AKT, ALOX5, AMPK, AMYLOID, amyotrophic lateral sclerosis
Therapeutic Agents	DIMETHYL FUMARATE, METFORMIN
KG Connections	724 knowledge graph edges
Databases	OMIM Orphanet ClinicalTrials PubMed

Pathway Diagram

graph TD
    MULTIPLE_SCLEROSIS["MULTIPLE SCLEROSIS"] -->|"associated"| OLIGODENDROCYTE["OLIGODENDROCYTE"]
    MULTIPLE_SCLEROSIS["MULTIPLE SCLEROSIS"] -->|"regulates"| NEUROINFLAMMATION["NEUROINFLAMMATION"]
    MULTIPLE_SCLEROSIS["MULTIPLE SCLEROSIS"] -->|"contributes to"| NEURODEGENERATION["NEURODEGENERATION"]
    MULTIPLE_SCLEROSIS["MULTIPLE SCLEROSIS"] -->|"protects against"| NEURODEGENERATION_1["NEURODEGENERATION"]
    MULTIPLE_SCLEROSIS["MULTIPLE SCLEROSIS"] -->|"treats"| NEUROINFLAMMATION_2["NEUROINFLAMMATION"]
    MULTIPLE_SCLEROSIS["MULTIPLE SCLEROSIS"] -->|"treats"| RIPK1["RIPK1"]
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"associated"| MULTIPLE_SCLEROSIS["MULTIPLE SCLEROSIS"]
    PARKINSON_S_DISEASE["PARKINSON'S DISEASE"] -->|"associated"| MULTIPLE_SCLEROSIS["MULTIPLE SCLEROSIS"]
    ALS["ALS"] -->|"associated"| MULTIPLE_SCLEROSIS["MULTIPLE SCLEROSIS"]
    MICROGLIA["MICROGLIA"] -->|"associated"| MULTIPLE_SCLEROSIS["MULTIPLE SCLEROSIS"]
    style MULTIPLE_SCLEROSIS fill:#ef5350,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (751)

Target	Relation	Type	Str
Neuroinflammation	therapeutic_target	disease	1.00
Neurodegeneration	associated_with	disease	1.00
Alzheimer	activates	disease	1.00
Inflammation	therapeutic_target	disease	1.00
Neurodegeneration	activates	disease	1.00
Neuroinflammation	activates	disease	1.00
Inflammation	regulates	disease	1.00
Stroke	associated_with	disease	1.00
Neurodegeneration	therapeutic_target	disease	1.00
Neurodegeneration	regulates	disease	1.00
Alzheimer	associated_with	disease	1.00
Inflammation	associated_with	disease	1.00
Inflammation	activates	disease	1.00
Oxidative Stress	therapeutic_target	pathway	1.00
Immune Response	therapeutic_target	pathway	1.00
Blood-Brain Barrier	therapeutic_target	pathway	1.00
Myelin Loss	causes	phenotype	0.95
Axonal Loss	causes	process	0.95
Alzheimer	regulates	disease	0.95
Axonal Damage	causes	phenotype	0.95
Central Nervous System	associated_with	cell_type	0.95
Demyelinating Disease	associated_with	process	0.95
Demyelination	associated_with	process	0.95
Inflammation	causes	disease	0.95
Visual System Degeneration	causes	phenotype	0.90
Oligodendrocyte	regulates	cell_type	0.90
Neurodegeneration	causes	process	0.90
Visual Pathway Degeneration	causes	process	0.90
oligodendrocytes	affects	cell_type	0.90
microglia	affects	cell_type	0.90
astrocytes	affects	cell_type	0.90
oxidative stress response	involves	pathway	0.90
Blood-Brain Barrier	causes	process	0.90
blood-brain barrier	involves	pathway	0.90
white matter	affects	brain_region	0.90
spinal cord	affects	brain_region	0.90
Acute Injury	associated_with	process	0.90
neurons	affects	cell_type	0.90
Oligodendrocyte	causes	cell_type	0.90
Axonal Loss	associated_with	phenotype	0.90
Brain Inflammation	causes	process	0.90
Demyelination	causes	phenotype	0.90
Neuronal Cell Death	causes	phenotype	0.90
Brain T1 Hypointensity	biomarker_for	biomarker	0.90
Neuroaxonal Injury	causes	phenotype	0.90
Autoimmune Response	causes	process	0.90
Periventricular T2 Lesion	biomarker_for	biomarker	0.90
Dawson'S Finger	biomarker_for	biomarker	0.90
Blood-Brain Barrier	activates	pathway	0.90
Immune Response	regulates	pathway	0.90

Incoming (1650)

Source	Relation	Type	Str
INFLAMMATION	activates	gene	1.00
MICROGLIA	associated_with	cell_type	1.00
NEURODEGENERATION	activates	gene	1.00
NEURODEGENERATIVE DISEASES	therapeutic_target	gene	1.00
ALS	associated_with	disease	1.00
ASTROCYTES	activates	gene	1.00
INFLAMMATION	causes	gene	1.00
OXIDATIVE STRESS	therapeutic_target	gene	1.00
Als	associated_with	disease	1.00
Parkinson	associated_with	disease	1.00
NEURODEGENERATION	therapeutic_target	gene	1.00
IL-6	associated_with	gene	1.00
CYTOKINES	activates	gene	1.00
Als	causes	disease	1.00
NEURODEGENERATION	regulates	gene	1.00
NEUROINFLAMMATION	therapeutic_target	gene	1.00
MICROGLIA	activates	gene	1.00
ALZHEIMER	associated_with	gene	1.00
INFLAMMATION	associated_with	gene	1.00
PARKINSON'S DISEASE	associated_with	disease	1.00
STROKE	associated_with	gene	1.00
NF-KB	associated_with	protein	1.00
AMYLOID	associated_with	protein	1.00
AKT	associated_with	gene	1.00
INFLAMMATION	therapeutic_target	gene	1.00
TNF	associated_with	gene	1.00
PI3K	associated_with	gene	1.00
ASTROCYTES	associated_with	cell_type	1.00
NEURODEGENERATION	causes	gene	1.00
PARKINSON	activates	gene	1.00
ALZHEIMER'S DISEASE	associated_with	gene	1.00
NEURODEGENERATION	associated_with	gene	1.00
NEURODEGENERATIVE DISEASES	associated_with	gene	1.00
ALZHEIMER	regulates	gene	1.00
ALZHEIMER'S DISEASE	associated_with	disease	1.00
astrocyte	associated_with	cell_type	1.00
ALZHEIMER'S DISEASE	activates	gene	1.00
Amyotrophic Lateral Sclerosis	associated_with	disease	1.00
INFLAMMATION	regulates	gene	1.00
Als	therapeutic_target	disease	1.00
PARKINSON	associated_with	gene	1.00
PARKINSON'S DISEASE	associated_with	gene	1.00
Parkinson	activates	disease	1.00
Als	activates	disease	1.00
PARKINSON'S DISEASE	activates	gene	1.00
NEUROINFLAMMATION	activates	gene	1.00
AMYOTROPHIC LATERAL SCLEROSIS	associated_with	gene	1.00
ALZHEIMER	activates	gene	1.00
TAU	associated_with	protein	0.98
ALZHEIMER'S DISEASE	activates	disease	0.98

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning MULTIPLE SCLEROSIS in their description or question text

No additional research found