gene

CDK1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CDK1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

340Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

Comprehensive page on CDK1, cell cycle kinase essential for G2/M transition, and its role in neuronal cell cycle re-entry and neurodegeneration in Alzheimer's and Parkinson's diseases

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🧬 Gene Info

Gene Symbol	CDK1
Full Name	Cyclin-Dependent Kinase 1
Chromosome	10q21.1
Protein Type	Kinase
Function	is a gene located on chromosome 10q21.
Primary Expression	Ubiquitous (neurons, glia, proliferating cells)
Molecular Weight	34 kDa
Amino Acids	297 aa
Pathways	Angiogenesis, Autophagy, Cell Cycle, Differentiation, Epigenetic
UniProt ID	P06493
NCBI Gene ID	983
Ensembl ID	ENSG00000164946
OMIM	176741
GeneCards	CDK1
Human Protein Atlas	CDK1
Associated Diseases	ALS, Cancer, Inflammation
Known Drugs/Compounds	rapamycin
Interactions	ACTB, Akt, ALZHEIMER, ALZHEIMER'S DISEASE, AMPK, AMYLOID
KG Connections	340 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: CDK1 — AlphaFold P06493 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (9)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    CDK1["CDK1"]
    CDK1 -->|"phosphorylates"| TP53["TP53"]
    CDK1 -->|"inhibits"| BECN1["BECN1"]
    CDK1 -->|"regulates"| CAPN6["CAPN6"]
    CDK1 -->|"regulates"| Als["Als"]
    CDK1 -->|"target for"| Senescence["Senescence"]
    CDK1 -->|"target for"| Ms["Ms"]
    CDK1 -->|"target for"| Tumor["Tumor"]
    CDK1 -->|"activates"| Glioma["Glioma"]
    BMAL1["BMAL1"] -->|"activates"| CDK1
    GENES["GENES"] -->|"activates"| CDK1
    CCNA1["CCNA1"] -->|"activates"| CDK1
    BRAF["BRAF"] -->|"target for"| CDK1
    ARNT["ARNT"] -->|"regulates"| CDK1
    PHAGOCYTOSIS["PHAGOCYTOSIS"] -->|"inhibits"| CDK1
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"inhibits"| CDK1
    BAX["BAX"] -->|"expressed in"| CDK1
    AGING["AGING"] -->|"target for"| CDK1
    DOCK2["DOCK2"] -->|"target for"| CDK1

Outgoing (215)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:CDK1	data_in	dataset_row	0.00
ds-83b31ef18d49	provides_data_for	dataset	1.00
Oncogene-Induced Senescence	involved_in	process	0.85
TP53	phosphorylates	protein	0.80
Tumor	therapeutic_target	disease	0.75
Tumor	activates	disease	0.75
Cancer	regulates	disease	0.75
Tumor	regulates	disease	0.75
Aging	therapeutic_target	disease	0.75
Cancer	activates	disease	0.75
Als	activates	disease	0.75
Cancer	therapeutic_target	disease	0.75
BECN1	inhibits	gene	0.70
CAPN6	regulates	protein	0.70
AKT	regulates	gene	0.70
Mapk	regulates	pathway	0.70
CANCER	regulates	gene	0.70
Senescence	inhibits	disease	0.65
Ms	regulates	disease	0.65
Aging	regulates	disease	0.65
Tumor	inhibits	disease	0.65
Cancer	associated_with	disease	0.65
ALS	regulates	disease	0.65
Stroke	inhibits	disease	0.65
Glioblastoma	activates	disease	0.65
Melanoma	regulates	disease	0.65
Diabetes	regulates	disease	0.65
Colorectal Cancer	regulates	disease	0.65
Ischemia	inhibits	disease	0.65
Ms	activates	disease	0.65
Ms	therapeutic_target	disease	0.65
Glioma	activates	disease	0.65
Senescence	activates	disease	0.65
Senescence	therapeutic_target	disease	0.65
Glioblastoma	expressed_in	disease	0.65
Pancreatic Cancer	therapeutic_target	disease	0.65
Carcinoma	therapeutic_target	disease	0.65
Inflammation	associated_with	disease	0.65
ALS	activates	disease	0.65
Autoimmune	therapeutic_target	disease	0.65
Stroke	therapeutic_target	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Parkinson	therapeutic_target	disease	0.65
Colorectal Cancer	activates	disease	0.65
Als	therapeutic_target	disease	0.65
Ms	expressed_in	disease	0.65
Neurodegeneration	activates	disease	0.65
Alzheimer	inhibits	disease	0.65
Als	regulates	disease	0.65
Ms	inhibits	disease	0.65

Incoming (125)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:CDK1	data_in	dataset_row	0.00
ds-83b31ef18d49	data_in	dataset	1.00
XHP	downregulates	drug	0.90
BMAL1	upregulates	protein	0.90
BMAL1	binds	gene	0.85
GENES	activates	gene	0.70
CANCER	therapeutic_target	gene	0.70
PI3K	regulates	gene	0.70
BMAL1	activates	gene	0.64
PI3K	associated_with	gene	0.60
FTH1	activates	gene	0.60
UBE2N	activates	gene	0.60
TAK1	causes	gene	0.60
CDK2	activates	gene	0.60
EGFR	expressed_in	gene	0.60
GBM	expressed_in	gene	0.60
CYCLIN B1	activates	gene	0.60
MYC	regulates	gene	0.60
PLK1	regulates	gene	0.60
AMBRA1	regulates	gene	0.60
NOS3	contributes_to	gene	0.60
MSH6	activates	gene	0.60
HDAC6	contributes_to	gene	0.60
CDK2	interacts_with	gene	0.60
AKT	therapeutic_target	gene	0.60
IRS1	regulates	gene	0.60
APOPTOSIS	associated_with	gene	0.60
P53	therapeutic_target	gene	0.60
DNA	therapeutic_target	gene	0.60
AND	interacts_with	gene	0.60
DNA	activates	gene	0.60
MEK	inhibits	gene	0.60
RNA	inhibits	gene	0.60
DNMT1	contributes_to	gene	0.60
PLK1	associated_with	gene	0.60
CDK5	activates	gene	0.60
APP	inhibits	gene	0.60
TAU	inhibits	gene	0.60
EGFR	interacts_with	gene	0.60
CHEK1	interacts_with	gene	0.60
rapamycin	targets	drug	0.60
AMPK	activates	gene	0.60
ATG	activates	gene	0.60
CLOCK	regulates	gene	0.60
ACTB	activates	gene	0.60
AURKB	activates	gene	0.60
BCL-2	inhibits	gene	0.60
ALZHEIMER	inhibits	gene	0.60
AMYLOID	inhibits	gene	0.60
TAU TANGLES	inhibits	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CDK1 in their description or question text

No additional research found

CDK1

Understanding Entity Pages

Summary

Wiki Pages (9)

CDK1 — Cyclin-Dependent Kinase 1

CDK11 — Cyclin-Dependent Kinase 11

CDK11A — Cyclin Dependent Kinase 11A

CDK12 — Cyclin-Dependent Kinase 12

CDK16 — Cyclin-Dependent Kinase 16 (PCTAIRE-1)

CDK1 Protein

CDK11B

CDK12 Protein

CDK11 Protein