gene

PP2A

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PP2A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

343Connections

1Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

PP2A is a gene implicated in neurodegeneration research. Key relationships include: activates, inhibits, associated with. Associated with Aging, Als, Alzheimer. Connected to 141 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	PP2A
Full Name	Protein Phosphatase 2 Scaffold Subunit A Alpha
Aliases	PPP2R1A
Chromosome	19q13.41
Protein Type	Protein
Subcellular Localization	, and biological function 2. In the healthy brain, PP2A continuously
Molecular Weight	65 kDa
Pathways	Wnt, Notch pathway, mTOR, mtor, Wnt signaling
UniProt ID	P30153
NCBI Gene ID	5518
Ensembl ID	ENSG00000114825
OMIM	605983
GeneCards	PP2A
Human Protein Atlas	PP2A
Associated Diseases	Aging, Als, Alzheimer, Alzheimer's disease, disease, neurodegeneration
Known Drugs/Compounds	donepezil, Donepezil, DONEPEZIL, metformin, rapamycin, resveratrol
Interactions	AKT, AKT1, ALPHA-SYNUCLEIN, ALZHEIMER, ALZHEIMER'S DISEASE, AMBRA1
KG Connections	343 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: PP2A — AlphaFold P30153 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (8)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    PP2A["PP2A"]
    tau["tau"]
    PP2A -->|"regulates"| tau
    Alzheimer{"Alzheimer"}
    PP2A -->|"activates"| Alzheimer
    Als{"Als"}
    PP2A -->|"activates"| Als
    Cancer{"Cancer"}
    PP2A -->|"inhibits"| Cancer
    PP2A -->|"inhibits"| Als
    Tumor{"Tumor"}
    PP2A -->|"inhibits"| Tumor
    Diabetes{"Diabetes"}
    PP2A -->|"activates"| Diabetes
    Ms{"Ms"}
    PP2A -->|"inhibits"| Ms
    STAR["STAR"]
    PP2A -->|"associated with"| STAR
    Neurogenesis(["Neurogenesis"])
    PP2A -->|"associated with"| Neurogenesis
    Notch(["Notch"])
    PP2A -->|"associated with"| Notch
    GAIN["GAIN"]
    PP2A -->|"inhibits"| GAIN
    oxidative_stress["oxidative stress"]
    oxidative_stress -->|"inhibits"| PP2A
    PTEN["PTEN"]
    PTEN -->|"regulates"| PP2A
    GSK3_["GSK3beta"]
    GSK3_ -->|"inhibits"| PP2A
    PTEN -->|"inhibits"| PP2A
    GAIN -->|"inhibits"| PP2A
    STAR -->|"associated with"| PP2A
    ERK["ERK"]
    ERK -->|"activates"| PP2A
    RCAN1["RCAN1"]
    RCAN1 -->|"associated with"| PP2A
    TNF["TNF"]
    TNF -->|"activates"| PP2A
    PI3K["PI3K"]
    PI3K -->|"associated with"| PP2A
    AKT["AKT"]
    AKT -->|"activates"| PP2A
    GLUCONEOGENIC_GENES["GLUCONEOGENIC GENES"]
    GLUCONEOGENIC_GENES -->|"activates"| PP2A
    style PP2A fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (217)

Target	Relation	Type	Str
AKT	inhibits	protein	0.90
Tau Phosphorylation	downregulates	process	0.85
Alzheimer	therapeutic_target	disease	0.75
Tumor	activates	disease	0.75
Als	activates	disease	0.75
oxidative stress response	participates_in	pathway	0.70
AMPK	activates	gene	0.70
Autophagy	inhibits	pathway	0.70
ALZHEIMER'S DISEASE	therapeutic_target	gene	0.70
ALZHEIMER	therapeutic_target	gene	0.70
tau	regulates	protein	0.70
KEAP1	activates	gene	0.70
NRF2	activates	gene	0.70
Parkinson	inhibits	disease	0.65
Als	interacts_with	disease	0.65
Cardiac	interacts_with	disease	0.65
Ms	contributes_to	disease	0.65
Alzheimer	protects_against	disease	0.65
Tauopathy	protects_against	disease	0.65
ALS	activates	disease	0.65
Alzheimer	activates	disease	0.65
Als	regulates	disease	0.65
Ms	regulates	disease	0.65
Cancer	activates	disease	0.65
Diabetes	activates	disease	0.65
Tumor	inhibits	disease	0.65
Ataxia	regulates	disease	0.65
Als	inhibits	disease	0.65
Cancer	inhibits	disease	0.65
Als	treats	disease	0.65
Neurodegeneration	treats	disease	0.65
Alzheimer	treats	disease	0.65
Neurodegeneration	therapeutic_target	disease	0.65
Inflammation	inhibits	disease	0.65
Neuroinflammation	inhibits	disease	0.65
Aging	therapeutic_target	disease	0.65
Tauopathy	inhibits	disease	0.65
Neurodegeneration	associated_with	disease	0.65
Ms	inhibits	disease	0.65
Cancer	therapeutic_target	disease	0.65
Aging	associated_with	disease	0.65
Als	associated_with	disease	0.65
Senescence	associated_with	disease	0.65
Alzheimer	associated_with	disease	0.65
Colorectal Cancer	inhibits	disease	0.65
Akt	associated_with	pathway	0.60
UBIQUITIN	associated_with	gene	0.60
PPP2R2A	regulates	gene	0.60
ULK1	activates	gene	0.60
neurodegeneration	protects_against	disease	0.60

Incoming (126)

Source	Relation	Type	Str
DONEPEZIL	activates	drug	0.80
oxidative stress	inhibits	phenotype	0.80
Donepezil	activates	drug	0.75
GSK3β	inhibits	protein	0.70
PTEN	inhibits	protein	0.70
TAU	inhibits	gene	0.70
oxidative stress	decreases	process	0.70
AUTOPHAGY	inhibits	gene	0.70
PTEN	regulates	protein	0.70
metformin	targets	drug	0.60
CK2	inhibits	gene	0.60
AND	activates	gene	0.60
GAIN	inhibits	gene	0.60
AKT	activates	gene	0.60
AKT	associated_with	gene	0.60
ERK1	activates	gene	0.60
TAU	activates	gene	0.60
MTOR	inhibits	gene	0.60
MYC	inhibits	gene	0.60
AMBRA1	inhibits	gene	0.60
TNF	inhibits	gene	0.60
neurogenesis	associated_with	process	0.60
NOTCH	associated_with	gene	0.60
CREB	associated_with	gene	0.60
OXIDATIVE STRESS	activates	gene	0.60
GENES	activates	gene	0.60
PARKINSON	inhibits	gene	0.60
NEURODEGENERATIVE DISEASES	inhibits	gene	0.60
ALZHEIMER	activates	gene	0.60
CAT	activates	gene	0.60
HMOX1	activates	gene	0.60
LAMP1	activates	gene	0.60
MCOLN1	activates	gene	0.60
MTOR	activates	gene	0.60
NFE2L2	activates	gene	0.60
APP	phosphorylates	gene	0.60
LRP1	activates	gene	0.60
ERK	activates	gene	0.60
ALZHEIMER'S DISEASE	activates	gene	0.60
APOPTOSIS	activates	gene	0.60
CANCER	inhibits	gene	0.60
ROS	activates	gene	0.60
AMPK	activates	gene	0.60
DNA	activates	gene	0.60
CANCER	activates	gene	0.60
NEURODEGENERATION	associated_with	gene	0.60
APOPTOSIS	inhibits	gene	0.60
NEURODEGENERATION	treats	gene	0.60
CYTOKINES	activates	gene	0.60
TAU	interacts_with	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Neuron-Specific Expression of Autophagy Inhibitory Phosphata	0.510	neurodegeneration	What mechanisms underlie neuronal resist

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PP2A in their description or question text

No additional research found

PP2A

Understanding Entity Pages

Summary

Wiki Pages (8)

PP2A Protein

PP2A Tau Phosphatase Pathway

PP2A Activator Therapy

PP2A Protein (Protein Phosphatase 2A)

PP2A B55β Regulatory Subunit