gene

BRIP1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about BRIP1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

29Connections

0Hypotheses

0Analyses

20Outgoing

9Incoming

0Experiments

0Debates

Summary

BRIP1 is a gene implicated in neurodegeneration research. Key relationships include: regulates, implicated in. Associated with Ataxia, Cancer. Connected to 16 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	BRIP1
Full Name	BRCA1 interacting protein C-terminal helicase 1
Chromosome	17q23.2
Function	Homologous Recombination (HR): BRIP1 collaborates with BRCA1 to resolve DNA double-strand breaks through homologous recombination.
Molecular Weight	130 kDa
Amino Acids	249 aa
UniProt ID	[Q9UQM7](https://www.uniprot.org/uniprot/Q9UQM7)
Ensembl ID	ENSG00000136492
GeneCards	BRIP1
Human Protein Atlas	BRIP1
Associated Diseases	Cancer
KG Connections	29 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

BRIP1 Gene

gene · 1811 words

→

BRIP1 Protein

protein · 760 words

→

Pathway Diagram

graph TD
    BRIP1["BRIP1"]
    Cancer{"Cancer"}
    BRIP1 -->|"regulates"| Cancer
    Ataxia{"Ataxia"}
    BRIP1 -->|"regulates"| Ataxia
    STK11["STK11"]
    BRIP1 -->|"regulates"| STK11
    CHEK2["CHEK2"]
    BRIP1 -->|"regulates"| CHEK2
    CANCER["CANCER"]
    BRIP1 -->|"regulates"| CANCER
    PTEN["PTEN"]
    BRIP1 -->|"regulates"| PTEN
    BRCA1["BRCA1"]
    BRIP1 -->|"regulates"| BRCA1
    PALB2["PALB2"]
    BRIP1 -->|"regulates"| PALB2
    CDH1["CDH1"]
    BRIP1 -->|"regulates"| CDH1
    RAD51["RAD51"]
    BRIP1 -->|"regulates"| RAD51
    NF1["NF1"]
    BRIP1 -->|"regulates"| NF1
    BRCA2["BRCA2"]
    BRIP1 -->|"regulates"| BRCA2
    ATM["ATM"]
    ATM -->|"regulates"| BRIP1
    TP53["TP53"]
    TP53 -->|"regulates"| BRIP1
    NBN["NBN"]
    NBN -->|"regulates"| BRIP1
    style BRIP1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (20)

Target	Relation	Type	Str
Ataxia	regulates	disease	0.65
Cancer	regulates	disease	0.65
Cancer	associated_with	disease	0.65
GENES	associated_with	gene	0.60
CANCER	associated_with	gene	0.60
GENE MUTATIONS	contributes_to	gene	0.60
CDH1	associated_with	gene	0.60
STK11	regulates	gene	0.60
CHEK2	regulates	gene	0.60
PTEN	regulates	gene	0.60
BRCA1	regulates	gene	0.60
PALB2	regulates	gene	0.60
RAD51	regulates	gene	0.60
NF1	regulates	gene	0.60
BRCA2	regulates	gene	0.60
PTEN	associated_with	gene	0.60
CANCER	regulates	gene	0.60
BRCA1	associated_with	gene	0.60
PALB2	contributes_to	gene	0.60
CDH1	regulates	gene	0.60

Incoming (9)

Source	Relation	Type	Str
AND	contributes_to	gene	0.60
ATM	regulates	gene	0.60
TP53	regulates	gene	0.60
NBN	regulates	gene	0.60
TP53	associated_with	gene	0.60
CHEK2	contributes_to	gene	0.60
BRCA2	associated_with	gene	0.60
ATM	contributes_to	gene	0.60
STK11	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning BRIP1 in their description or question text

No additional research found