protein

RAC1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RAC1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

490Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

RAC1 is a Rho GTPase regulating actin cytoskeleton, synaptic plasticity, mitochondrial dynamics, and neuroinflammation in neurodegenerative diseases including Alzheimer's and Parkinson's

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🔬 Protein Info

Gene Symbol	RAC1
Function	is an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight	21.4 kDa
Amino Acids	192 aa
Pathways	Apoptosis, Autophagy, Dendritic Spine, Mtor, Nf-Κb
Ensembl ID	ENSG00000136238
GeneCards	RAC1
Human Protein Atlas	RAC1
Associated Diseases	Als, Cancer, Diabetes, Encephalitis, Inflammation
Interactions	ACTB, Actin, ACVR1, AKT, AKT1, ALZHEIMER
KG Connections	487 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

RAC1 Gene

gene · 2729 words

→

RAC1 Protein

protein · 2057 words

→

Pathway Diagram

flowchart TD
    RAC1["RAC1
Small GTPase"]
    HACE1["HACE1
E3 Ubiquitin Ligase"]
    YAP["YAP
Transcriptional
Coactivator"]
    PIK3C3["PIK3C3
Autophagy Regulator"]
    ATG14["ATG14
Autophagy Gene"]
    GJA1["GJA1
Gap Junction
Protein"]
    LAMP1["LAMP1
Lysosomal Protein"]
    
    ALS["Amyotrophic
Lateral Sclerosis"]
    MS["Multiple
Sclerosis"]
    PD["Parkinson's
Disease"]
    Stroke["Stroke"]
    TBI["Traumatic
Brain Injury"]
    Inflammation["Neuroinflammation"]
    
    Autophagy["Autophagy
Dysfunction"]
    CellMigration["Cell Migration
 and Motility"]
    Neuroprotection["Neuroprotective
Response"]
    
    HACE1 -->|"regulates"| RAC1
    RAC1 -->|"activates"| YAP
    RAC1 -->|"regulates"| PIK3C3
    RAC1 -->|"regulates"| ATG14
    RAC1 -->|"regulates"| GJA1
    RAC1 -->|"associates_with"| LAMP1
    
    PIK3C3 -->|"promotes"| Autophagy
    ATG14 -->|"promotes"| Autophagy
    LAMP1 -->|"facilitates"| Autophagy
    
    RAC1 -->|"promotes"| CellMigration
    YAP -->|"enhances"| CellMigration
    
    RAC1 -->|"inhibits"| TBI
    RAC1 -->|"promotes"| Neuroprotection
    RAC1 -->|"therapeutic_target"| ALS
    RAC1 -->|"therapeutic_target"| MS
    RAC1 -->|"therapeutic_target"| PD
    RAC1 -->|"therapeutic_target"| Inflammation
    
    RAC1 -->|"activates"| ALS
    RAC1 -->|"activates"| Stroke
    Autophagy -->|"contributes_to"| ALS
    Inflammation -->|"worsens"| MS
    
    style RAC1 fill:#006494
    style HACE1 fill:#4a1a6b
    style PIK3C3 fill:#4a1a6b
    style ATG14 fill:#4a1a6b
    style Neuroprotection fill:#1b5e20
    style TBI fill:#ef5350
    style ALS fill:#ef5350
    style MS fill:#ef5350
    style Stroke fill:#ef5350
    style Inflammation fill:#ef5350
    style Autophagy fill:#5d4400
    style CellMigration fill:#5d4400

Outgoing (310)

Target	Relation	Type	Str
Synapse Formation	regulates	process	0.88
Synaptogenesis	involved_in	process	0.85
Type 2 Diabetes Mellitus with Parkinson's Disease	biomarker_for	disease	0.80
Synoviocyte Hyperplasia	promotes	phenotype	0.80
Oxidative Stress	associated_with	process	0.80
Tumor	associated_with	disease	0.65
ALS	activates	disease	0.65
Tumor	regulates	disease	0.65
Cancer	expressed_in	disease	0.65
Huntington	contributes_to	disease	0.65
Inflammation	activates	disease	0.65
Alzheimer	contributes_to	disease	0.65
Ms	regulates	disease	0.65
Stroke	activates	disease	0.65
Als	activates	disease	0.65
Traumatic Brain Injury	inhibits	disease	0.65
Als	inhibits	disease	0.65
Ms	inhibits	disease	0.65
ALS	regulates	disease	0.65
Ms	associated_with	disease	0.65
Cardiovascular	activates	disease	0.65
Ms	activates	disease	0.65
Cancer	associated_with	disease	0.65
Als	associated_with	disease	0.65
Cardiac	therapeutic_target	disease	0.65
Als	regulates	disease	0.65
Glioblastoma	activates	disease	0.65
Cancer	activates	disease	0.65
Tumor	activates	disease	0.65
Obesity	therapeutic_target	disease	0.65
Cardiovascular	therapeutic_target	disease	0.65
Diabetes	therapeutic_target	disease	0.65
Inflammation	associated_with	disease	0.65
Diabetes	associated_with	disease	0.65
Cancer	therapeutic_target	disease	0.65
Parkinson	interacts_with	disease	0.65
Ms	interacts_with	disease	0.65
Als	therapeutic_target	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Aging	interacts_with	disease	0.65
Als	interacts_with	disease	0.65
Cancer	interacts_with	disease	0.65
Lymphoma	interacts_with	disease	0.65
Tumor	interacts_with	disease	0.65
Ms	therapeutic_target	disease	0.65
Parkinson	therapeutic_target	disease	0.65
Cancer	causes	disease	0.65
Cancer	regulates	disease	0.65
Alzheimer	activates	disease	0.65
Neurodegeneration	expressed_in	disease	0.65

Incoming (180)

Source	Relation	Type	Str
ARHGEF7	activates	protein	0.90
VAV2	phosphorylates	protein	0.85
ARHGEF2	activates	gene	0.80
SAA	binds	protein	0.80
PLEKHG5	activates	gene	0.80
HACE1	interacts_with	protein	0.70
TPM2	associated_with	gene	0.70
DENND3	regulates	gene	0.60
PARKINSON	therapeutic_target	gene	0.60
ROS	activates	gene	0.60
AMYLOID	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
AXON	activates	gene	0.60
VESICLE TRAFFICKING	activates	gene	0.60
NEURON	activates	gene	0.60
PCSK9	activates	gene	0.60
CREB	associated_with	gene	0.60
ERK1/2	associated_with	gene	0.60
PARKINSON	associated_with	gene	0.60
TUBB3	associated_with	gene	0.60
STK11	associated_with	gene	0.60
VIM	associated_with	gene	0.60
BECN1	regulates	gene	0.60
HDAC6	associated_with	gene	0.60
GAPDH	regulates	gene	0.60
MAP1LC3B	associated_with	gene	0.60
MAP3K5	associated_with	gene	0.60
UVRAG	associated_with	gene	0.60
H2AX	regulates	gene	0.60
OCLN	associated_with	gene	0.60
IL6	activates	gene	0.60
STAT3	activates	gene	0.60
SOD2	therapeutic_target	gene	0.60
CDC42	therapeutic_target	gene	0.60
CYCS	therapeutic_target	gene	0.60
GFAP	therapeutic_target	gene	0.60
SRC	inhibits	gene	0.60
VEGF	inhibits	gene	0.60
RBFOX2	expressed_in	gene	0.60
RUBCN	interacts_with	gene	0.60
GAIN	activates	gene	0.60
TAK1	associated_with	gene	0.60
TIRAP	associated_with	gene	0.60
PAK1	associated_with	gene	0.60
MYD88	associated_with	gene	0.60
NEK7	associated_with	gene	0.60
JNK	associated_with	gene	0.60
TRAF6	associated_with	gene	0.60
LIMK1	associated_with	gene	0.60
RAS	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning RAC1 in their description or question text

No additional research found