gene

PALB2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PALB2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

57Connections

0Hypotheses

0Analyses

28Outgoing

29Incoming

0Experiments

0Debates

Summary

PALB2 (Partner And Localizer of BRCA2) is a DNA repair protein essential for homologous recombination. It plays critical roles in maintaining genomic stability and is associated with Fanconi anemia and increased cancer risk.

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🧬 Gene Info

Gene Symbol	PALB2
Full Name	Partner And Localizer of BRCA2
Chromosome	16p12.2
Function	encodes a critical DNA repair protein that serves as a central hub in the Fanconi anemia pathway and homologous recombination repair.
Molecular Weight	130 kDa
Amino Acids	1186 aa
Ensembl ID	ENSG00000083093
GeneCards	PALB2
Human Protein Atlas	PALB2
FA core complex	PALB2 interacts with the FA core complex
ID complex	Works with FANCD2-I (FANCI) for downstream signaling
BRCA complex	Part of the BRCA1-PALB2-BRCA2-RAD51 complex
Crosslink repair	Essential for interstrand crosslink repair
Associated Diseases	Cancer
Interactions	BRCA1, DNA, RAD18, UBIQUITIN
KG Connections	57 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

PALB2 Gene

gene · 1623 words

→

PALB2 Protein - Partner and Localizer of BRCA2

protein · 1879 words

→

Pathway Diagram

graph TD
    PALB2["PALB2"]
    Als{"Als"}
    PALB2 -->|"therapeutic target"| Als
    Ms{"Ms"}
    PALB2 -->|"therapeutic target"| Ms
    Cancer{"Cancer"}
    PALB2 -->|"associated with"| Cancer
    Carcinoma{"Carcinoma"}
    PALB2 -->|"therapeutic target"| Carcinoma
    PALB2 -->|"regulates"| Cancer
    Ataxia{"Ataxia"}
    PALB2 -->|"regulates"| Ataxia
    GENE_MUTATIONS["GENE MUTATIONS"]
    PALB2 -->|"therapeutic target"| GENE_MUTATIONS
    ATM["ATM"]
    PALB2 -->|"associated with"| ATM
    BRCA2["BRCA2"]
    PALB2 -->|"associated with"| BRCA2
    CDH1["CDH1"]
    PALB2 -->|"regulates"| CDH1
    RAD51["RAD51"]
    PALB2 -->|"regulates"| RAD51
    NF1["NF1"]
    PALB2 -->|"regulates"| NF1
    CDKN2A["CDKN2A"]
    CDKN2A -->|"associated with"| PALB2
    TP53["TP53"]
    TP53 -->|"associated with"| PALB2
    CANCER["CANCER"]
    CANCER -->|"associated with"| PALB2
    MLH1["MLH1"]
    MLH1 -->|"associated with"| PALB2
    BRCA1["BRCA1"]
    BRCA1 -->|"associated with"| PALB2
    ATM -->|"regulates"| PALB2
    TP53 -->|"regulates"| PALB2
    NBN["NBN"]
    NBN -->|"regulates"| PALB2
    BRIP1["BRIP1"]
    BRIP1 -->|"regulates"| PALB2
    STK11["STK11"]
    STK11 -->|"regulates"| PALB2
    CHEK2["CHEK2"]
    CHEK2 -->|"regulates"| PALB2
    CANCER -->|"regulates"| PALB2
    style PALB2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (28)

Target	Relation	Type	Str
Als	therapeutic_target	disease	0.75
Ms	therapeutic_target	disease	0.65
Cancer	associated_with	disease	0.65
Carcinoma	therapeutic_target	disease	0.65
Cancer	regulates	disease	0.65
Ataxia	regulates	disease	0.65
Tumor	therapeutic_target	disease	0.65
Cancer	therapeutic_target	disease	0.65
Breast Cancer	therapeutic_target	disease	0.65
Aging	therapeutic_target	disease	0.65
Als	activates	disease	0.65
DNA	activates	gene	0.60
T Cell	activates	cell_type	0.60
UBIQUITIN	activates	gene	0.60
autophagy pathway	participates_in	pathway	0.60
neurons	expressed_in	cell_type	0.60
GENE MUTATIONS	therapeutic_target	gene	0.60
PIK3CA	therapeutic_target	gene	0.60
CDH1	regulates	gene	0.60
Differentiation	therapeutic_target	pathway	0.60
GENE MUTATIONS	contributes_to	gene	0.60
CDH1	associated_with	gene	0.60
ATM	associated_with	gene	0.60
BRCA2	associated_with	gene	0.60
RAD51	regulates	gene	0.60
NF1	regulates	gene	0.60
BRCA2	regulates	gene	0.60
PTEN	associated_with	gene	0.60

Incoming (29)

Source	Relation	Type	Str
CANCER	associated_with	gene	0.60
CANCER	regulates	gene	0.60
CANCER	therapeutic_target	gene	0.60
AND	contributes_to	gene	0.60
GENES	associated_with	gene	0.60
DNA	inhibits	gene	0.60
CHEK2	contributes_to	gene	0.60
BRCA2	associated_with	gene	0.60
ATM	contributes_to	gene	0.60
STK11	associated_with	gene	0.60
BRIP1	contributes_to	gene	0.60
CDKN2A	associated_with	gene	0.60
TP53	associated_with	gene	0.60
MLH1	associated_with	gene	0.60
BRCA1	associated_with	gene	0.60
ATM	regulates	gene	0.60
TP53	regulates	gene	0.60
NBN	regulates	gene	0.60
BRIP1	regulates	gene	0.60
STK11	regulates	gene	0.60
CHEK2	regulates	gene	0.60
PTEN	regulates	gene	0.60
BRCA1	regulates	gene	0.60
RAD18	activates	gene	0.60
PTEN	therapeutic_target	gene	0.60
TP53	therapeutic_target	gene	0.60
BRCA1	therapeutic_target	gene	0.60
BRCA1	inhibits	gene	0.60
ATG7	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PALB2 in their description or question text

No additional research found