Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Lupus: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Associated Genes | ALZHEIMER, ALZHEIMER'S DISEASE, AND, ATG16L2, ATG5, ATG7, AUTOPHAGY, BECN1 |
| KG Connections | 280 knowledge graph edges |
| Databases | OMIMOrphanetClinicalTrialsPubMed |
graph TD
Lupus["Lupus"]
Als{"Als"}
Lupus -->|"therapeutic_target"| Als
Apoptosis["Apoptosis"]
Lupus -->|"therapeutic_target"| Apoptosis
Autoimmune{"Autoimmune"}
Lupus -->|"contributes_to"| Autoimmune
Nf__b["Nf-Kappab"]
Lupus -->|"therapeutic_target"| Nf__b
CYTOKINES(["CYTOKINES"])
CYTOKINES -->|"activates"| Lupus
APOPTOSIS(["APOPTOSIS"])
APOPTOSIS -->|"therapeutic_target"| Lupus
IL_6(["IL-6"])
IL_6 -->|"activates"| Lupus
CGAS(["CGAS"])
CGAS -->|"regulates"| Lupus
style Lupus fill:#1a3a4a,stroke:#ef5350,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Als | activates | disease | 0.85 |
| Als | therapeutic_target | disease | 0.85 |
| Apoptosis | therapeutic_target | pathway | 0.80 |
| Autoimmune | regulates | disease | 0.75 |
| Autoimmune | associated_with | disease | 0.75 |
| Immune Response | causes | pathway | 0.70 |
| Phagocytosis | associated_with | pathway | 0.70 |
| Glycolysis | activates | pathway | 0.70 |
| Lipid Metabolism | activates | pathway | 0.70 |
| Oxidative Phosphorylation | activates | pathway | 0.70 |
| Adaptive Immunity | contributes_to | pathway | 0.70 |
| Autophagy | associated_with | pathway | 0.70 |
| Nf-Κb | therapeutic_target | pathway | 0.70 |
| Differentiation | activates | pathway | 0.70 |
| Autoimmune | therapeutic_target | disease | 0.65 |
| Autoimmune | activates | disease | 0.65 |
| Autophagy | regulates | pathway | 0.65 |
| Autoimmune | causes | disease | 0.65 |
| Als | associated_with | disease | 0.65 |
| Autoimmune | inhibits | disease | 0.65 |
| Inflammation | inhibits | disease | 0.65 |
| Inflammation | activates | disease | 0.65 |
| Immune Response | therapeutic_target | pathway | 0.60 |
| Mtor | activates | pathway | 0.60 |
| Mitophagy | activates | pathway | 0.60 |
| Mitophagy | contributes_to | pathway | 0.60 |
| Autophagy | activates | pathway | 0.60 |
| Inflammasome | contributes_to | pathway | 0.60 |
| Epigenetic | implicated_in | pathway | 0.60 |
| Differentiation | causes | pathway | 0.60 |
| Mtor | regulates | pathway | 0.60 |
| Differentiation | biomarker_for | pathway | 0.60 |
| Ferroptosis | regulates | pathway | 0.60 |
| Apoptosis | inhibits | pathway | 0.60 |
| Immune Response | associated_with | pathway | 0.60 |
| Tgf-Β | therapeutic_target | pathway | 0.60 |
| Mapk | regulates | pathway | 0.60 |
| Metastasis | activates | pathway | 0.60 |
| Sphingolipid | activates | pathway | 0.60 |
| Epigenetic | therapeutic_target | pathway | 0.60 |
| Mtor | associated_with | pathway | 0.60 |
| Immune Response | interacts_with | pathway | 0.60 |
| Inflammasome | activates | pathway | 0.60 |
| Inflammasome | regulates | pathway | 0.60 |
| Complement | therapeutic_target | pathway | 0.60 |
| Innate Immunity | contributes_to | pathway | 0.60 |
| Immune Response | activates | pathway | 0.60 |
| Epigenetic | activates | pathway | 0.60 |
| Nf-Κb | regulates | pathway | 0.60 |
| Phagocytosis | interacts_with | pathway | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| CYTOKINES | activates | gene | 0.95 |
| IL-6 | activates | gene | 0.85 |
| APOPTOSIS | therapeutic_target | gene | 0.85 |
| CGAS | regulates | gene | 0.85 |
| CGAS-STING | regulates | gene | 0.75 |
| STING | regulates | gene | 0.75 |
| INFLAMMATION | inhibits | gene | 0.75 |
| C1Q | associated_with | gene | 0.75 |
| DNA | associated_with | gene | 0.75 |
| PHAGOCYTOSIS | associated_with | gene | 0.75 |
| STAT3 | therapeutic_target | gene | 0.75 |
| LC3 | associated_with | gene | 0.75 |
| NF-ΚB | therapeutic_target | gene | 0.75 |
| AUTOPHAGY | associated_with | gene | 0.75 |
| JAK1 | activates | gene | 0.75 |
| CYTOKINES | therapeutic_target | gene | 0.75 |
| INFLAMMATION | activates | gene | 0.75 |
| NLRP3 | activates | gene | 0.75 |
| ALZHEIMER'S DISEASE | associated_with | gene | 0.65 |
| STROKE | associated_with | gene | 0.65 |
| S100A8 | associated_with | gene | 0.65 |
| NEUROINFLAMMATION | therapeutic_target | gene | 0.65 |
| TNF | inhibits | gene | 0.65 |
| APOPTOSIS | inhibits | gene | 0.65 |
| CYTOKINES | inhibits | gene | 0.65 |
| IL-6 | inhibits | gene | 0.65 |
| TNF-Α | inhibits | gene | 0.65 |
| AUTOPHAGY | activates | gene | 0.65 |
| PARKIN | inhibits | gene | 0.65 |
| Infection | implicated_in | disease | 0.65 |
| PINK1 | inhibits | gene | 0.65 |
| PIEZO1 | therapeutic_target | gene | 0.65 |
| MITOCHONDRIAL DYSFUNCTION | therapeutic_target | gene | 0.65 |
| OXIDATIVE STRESS | therapeutic_target | gene | 0.65 |
| ROS | inhibits | gene | 0.65 |
| EGF | associated_with | gene | 0.65 |
| DR3 | associated_with | gene | 0.65 |
| ATG5 | associated_with | gene | 0.65 |
| CDKN1B | associated_with | gene | 0.65 |
| ATG7 | associated_with | gene | 0.65 |
| RUBCN | associated_with | gene | 0.65 |
| CYBB | associated_with | gene | 0.65 |
| LRRK2 | associated_with | gene | 0.65 |
| MTORC1 | associated_with | gene | 0.65 |
| MAP1LC3B | associated_with | gene | 0.65 |
| BECN1 | associated_with | gene | 0.65 |
| CANCER | associated_with | gene | 0.65 |
| P53 | therapeutic_target | gene | 0.65 |
| TRIM21 | contributes_to | gene | 0.65 |
| BCL2 | therapeutic_target | gene | 0.65 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning Lupus in their description or question text
No additional research found