Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CBP: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | CBP |
| Key Genes/Proteins | ACAT1, ACLY, AMPK, APC, ATG, AXIN1 |
| Related Pathways | apoptosis pathway, autophagy pathway |
Knowledge base pages for this entity
graph TD
CBP[CBP]
CBP -->|activates| BDNF[BDNF]
CBP -->|inhibits| SIRT1[SIRT1]
CBP -->|participates in| epigenetic_regulation[epigenetic regulation]
CBP -->|regulates| CREB[CREB]
CBP -->|activates| NEURODEGENERATION[NEURODEGENERATION]
CBP -->|regulates| NEURONS[NEURONS]
CBP -->|activates| CREBBP[CREBBP]
CBP -->|activates| EP300[EP300]
ASTROCYTES[ASTROCYTES] -->|activates| CBP
BECN1[BECN1] -->|activates| CBP
CALCOCO2[CALCOCO2] -->|activates| CBP
BDNF -->|regulates| CBP
APC[APC] -->|regulates| CBP
AXIN1[AXIN1] -->|regulates| CBP
AXIN2[AXIN2] -->|regulates| CBP
BRG1[BRG1] -->|regulates| CBP
ACAT1[ACAT1] -->|activates| CBP
AMPK[AMPK] -->|activates| CBP| Target | Relation | Type | Str |
|---|---|---|---|
| benchmark_ot_ad_answer_key:CBP | data_in | dataset_row | 0.00 |
| BDNF | activates | gene | 0.90 |
| epigenetic regulation | participates_in | pathway | 0.70 |
| CREB | regulates | gene | 0.70 |
| SIRT1 | inhibits | gene | 0.70 |
| NEURODEGENERATION | activates | phenotype | 0.70 |
| NEURONS | regulates | cell_type | 0.65 |
| CREB | inhibits | gene | 0.65 |
| BDNF | regulates | protein | 0.64 |
| SIRT1 | interacts_with | gene | 0.60 |
| CREB | activates | gene | 0.60 |
| GSK3 | activates | gene | 0.60 |
| MAP1LC3 | activates | gene | 0.60 |
| PKM2 | activates | gene | 0.60 |
| RUBCNL | activates | gene | 0.60 |
| Parkinson's disease | activates | disease | 0.60 |
| autophagy pathway | participates_in | pathway | 0.60 |
| apoptosis pathway | participates_in | pathway | 0.60 |
| Wnt signaling | participates_in | pathway | 0.60 |
| ubiquitin-proteasome | participates_in | pathway | 0.60 |
| neurons | expressed_in | cell_type | 0.60 |
| EP300 | interacts_with | gene | 0.60 |
| P300 | interacts_with | gene | 0.60 |
| HSC70 | activates | gene | 0.60 |
| SNARE | activates | gene | 0.60 |
| VPS34 | activates | gene | 0.60 |
| oxidative stress response | participates_in | pathway | 0.60 |
| traumatic brain injury | activates | disease | 0.60 |
| traumatic brain injury | inhibits | disease | 0.60 |
| HDAC6 | activates | gene | 0.60 |
| HSPA8 | activates | gene | 0.60 |
| KAT2A | activates | gene | 0.60 |
| KAT2B | activates | gene | 0.60 |
| KAT5 | activates | gene | 0.60 |
| KAT8 | activates | gene | 0.60 |
| LAMP2A | activates | gene | 0.60 |
| LC3 | activates | gene | 0.60 |
| MTOR | activates | gene | 0.60 |
| NBR1 | activates | gene | 0.60 |
| NDP52 | activates | gene | 0.60 |
| OPTN | activates | gene | 0.60 |
| PIK3C3 | activates | gene | 0.60 |
| RB1 | activates | gene | 0.60 |
| RB1CC1 | activates | gene | 0.60 |
| RUBCN | activates | gene | 0.60 |
| SIRT1 | activates | gene | 0.60 |
| SNAP29 | activates | gene | 0.60 |
| SQSTM1 | activates | gene | 0.60 |
| STX17 | activates | gene | 0.60 |
| TFEB | activates | gene | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| benchmark_ot_ad_answer_key:CBP | data_in | dataset_row | 0.00 |
| ASTROCYTES | activates | cell_type | 0.70 |
| APC | regulates | gene | 0.60 |
| AXIN1 | regulates | gene | 0.60 |
| AXIN2 | regulates | gene | 0.60 |
| BRG1 | regulates | gene | 0.60 |
| ACAT1 | activates | gene | 0.60 |
| AMPK | activates | gene | 0.60 |
| ATG | activates | gene | 0.60 |
| rapamycin | targets | drug | 0.60 |
| BDNF | regulates | gene | 0.60 |
| AMPK | regulates | gene | 0.60 |
| BECN1 | activates | gene | 0.60 |
| CALCOCO2 | activates | gene | 0.60 |
| ACLY | activates | gene | 0.55 |
| BDNF | activates | gene | 0.55 |
| HIPPOCAMPUS | associated_with | brain_region | 0.45 |
| RAPAMYCIN | associated_with | drug | 0.45 |
| PARKINSON | associated_with | disease | 0.45 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning CBP in their description or question text
No additional research found