Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about LAP: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| ATG8 | activates | protein | 0.64 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Hypothesis 4: Metabolic Coupling via Lactate-Shuttling Colla | 0.895 | neurodegeneration | View |
| PARP1-NAD+-AIF bioenergetic collapse drives a self-amplifyin | 0.760 | neurodegeneration | What mechanisms drive the self-amplifyin |
| H1: T-Type Calcium Channel–Driven Calcium Overload and Prote | 0.730 | neurodegeneration | Entorhinal cortex layer II vulnerability |
| TREM2 R47H variant synergizes with APOE4 to collapse microgl | 0.670 | neuroscience | APOE4-driven lipid metabolism dysregulat |
| Mitophagy collapse via PINK1-PRKN is the primary autophagy l | 0.614 | neurodegeneration | What specific autophagy pathways are def |
| H2: H3K9me3 Heterochromatin Collapse Enables Cryptic Transcr | 0.610 | neurodegeneration | Investigate mechanisms of epigenetic rep |
| Myelin Breakdown-Amyloid Interaction Amplifies Cortical Agin | 0.584 | Alzheimer disease | Allen Mouse Brain Aging Atlas: cross-age |
| Ferroptosis as Epiphenomenon of Terminal Collapse | 0.363 | neurodegeneration | Is ferroptosis the primary driver of mot |
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Discovery of an APP-selective BACE1 inhibitor for Alzheimer's disease. [PMID:40399225] | Unknown | Neurotherapeutics : the journa | 2025 | 0 |
| Discovery of an APP-selective BACE1 inhibitor for Alzheimer's disease. [PMID:40399225] | Campagna, Jagodzinska, Wi, Zhu, Lee et a | Neurotherapeutics : the journa | 2025 | 0 |
| Amyloid fibrils of the myelin basic protein are an integral component of myelin [PMID:40781105] | Sysoev EI, Shenfeld AA, Belashova TA | Sci Rep | 2025 | 0 |
| Licochalcone A prevents cognitive decline in a lipopolysaccharide-induced neuroi [PMID:39930360] | Carrasco M, Guzman L, Olloquequi J, Cano | Molecular medicine (Cambridge, | 2025 | 0 |
| β-asarone improves cognitive impairment and alleviates autophagy in mice with va [PMID:38039902] | Ning, Zhong, Wu, Wang, Hu et al. | Phytomedicine : international | 2024 | 0 |
| Myelin basic protein mRNA levels affect myelin sheath dimensions, architecture, [PMID:39023138] | Bagheri H, Friedman H, Hadwen A | Glia | 2024 | 0 |
| β-asarone improves cognitive impairment and alleviates autophagy in mice with va [PMID:38039902] | Unknown | Phytomedicine : international | 2024 | 0 |
| Pathological remodeling of reactive astrocytes: Involvement of DNA methylation a [PMID:38943350] | Cuautle DG, Donna S, Cieri MB, Villarrea | Journal of neurochemistry | 2024 | 0 |
| Myelin basic protein and index for neuro-Behçet's disease. [PMID:36907539] | Zhan H, Cheng L, Wang X | Clin Immunol | 2023 | 0 |
| The Effect of Mindfulness-based Programs on Cognitive Function in Adults: A Syst [PMID:34350544] | Whitfield, Barnhofer, Acabchuk, Cohen, L | Neuropsychology review | 2022 | 0 |
| Multiple sclerosis and myelin basic protein: insights into protein disorder and [PMID:34889995] | Martinsen V, Kursula P | Amino Acids | 2022 | 0 |
| The Effect of Mindfulness-based Programs on Cognitive Function in Adults: A Syst [PMID:34350544] | Unknown | Neuropsychology review | 2022 | 0 |
| An update on diagnostic and prognostic biomarkers for traumatic brain injury. [PMID:29338452] | Unknown | Expert review of molecular dia | 2019 | 0 |
| An update on diagnostic and prognostic biomarkers for traumatic brain injury. [PMID:29338452] | Unknown | Expert review of molecular dia | 2019 | 0 |
| An updated histological classification system for multiple sclerosis lesions. [PMID:27988845] | Kuhlmann T, Ludwin S, Prat A | Acta Neuropathol | 2017 | 0 |
| What do your eyes reveal about your foreign language? Reading emotional sentence [PMID:28973016] | ["Iacozza, Sara", "Costa, Albert", "Du\u | PloS one | 2017 | 0 |
| What do your eyes reveal about your foreign language? Reading emotional sentence [PMID:28973016] | ["Iacozza, Sara", "Costa, Albert", "Du\u | PloS one | 2017 | 0 |
| Oligodendroglia metabolically support axons and contribute to neurodegeneration. [PMID:22801498] | Lee Y, Morrison BM, Li Y, Lengacher S, F | Nature | 2012 | 0 |
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning LAP in their description or question text
Score: 0.610 · neurodegeneration · 2026-04-22
## Mechanistic Overview H2: H3K9me3 Heterochromatin Collapse Enables Cryptic Transcription of Repetitive Elements starts
Score: 0.584 · Alzheimer disease · 2026-04-24
## Mechanistic Overview Myelin Breakdown-Amyloid Interaction Amplifies Cortical Aging-Neurodegeneration Overlap starts f
Score: 0.363 · neurodegeneration · 2026-04-18
## Mechanistic Overview Ferroptosis as Epiphenomenon of Terminal Collapse starts from the claim that modulating not yet