protein

SMURF1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SMURF1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

59Connections

0Hypotheses

0Analyses

40Outgoing

19Incoming

0Experiments

0Debates

Summary

SMURF1 is a protein involved in neurodegeneration research. Key relationships include: activates, regulates, interacts with. Associated with Als, Carcinoma, Hepatocellular Carcinoma. Connected to 44 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	SMURF1
Function	SMURF1 (SMAD Specific E3 Ubiquitin Protein Ligase 1) is a HECT-type E3 ubiquitin ligase primarily known for its role in regulating TGF-β signaling through degradation of SMAD proteins.
Pathways	TGF-β signaling, TGF-β
GeneCards	SMURF1
Human Protein Atlas	SMURF1
Associated Diseases	Freezing Tolerance
Interactions	AND, APOPTOSIS, AUTOPHAGY, BECN1, CALCINEURIN, DDIT3
KG Connections	59 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

SMURF1 Protein

protein · 573 words

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Pathway Diagram

graph TD
    SMURF1["SMURF1"]
    Mycobacterium_tuberculosis["Mycobacterium tuberculosis"]
    SMURF1 -->|"protects against"| Mycobacterium_tuberculosis
    M__tuberculosis(["M. tuberculosis"])
    SMURF1 -->|"modifies"| M__tuberculosis
    PPP3CB["PPP3CB"]
    SMURF1 -->|"ubiquitinates"| PPP3CB
    Carcinoma{"Carcinoma"}
    SMURF1 -->|"activates"| Carcinoma
    Als{"Als"}
    SMURF1 -->|"regulates"| Als
    SMURF1 -->|"interacts with"| Als
    Ms{"Ms"}
    SMURF1 -->|"activates"| Ms
    Tumor{"Tumor"}
    SMURF1 -->|"activates"| Tumor
    CSNK1A1["CSNK1A1"]
    SMURF1 -->|"regulates"| CSNK1A1
    UVRAG["UVRAG"]
    SMURF1 -->|"activates"| UVRAG
    BECN1["BECN1"]
    SMURF1 -->|"activates"| BECN1
    Mtor(["Mtor"])
    SMURF1 -->|"activates"| Mtor
    PIK3C3["PIK3C3"]
    PIK3C3 -->|"activates"| SMURF1
    RUBCN["RUBCN"]
    RUBCN -->|"activates"| SMURF1
    PPP3CB -->|"activates"| SMURF1
    MAVS["MAVS"]
    MAVS -->|"activates"| SMURF1
    UBIQUITIN["UBIQUITIN"]
    UBIQUITIN -->|"activates"| SMURF1
    MTOR["MTOR"]
    MTOR -->|"inhibits"| SMURF1
    LYSOSOMAL_BIOGENESIS["LYSOSOMAL BIOGENESIS"]
    LYSOSOMAL_BIOGENESIS -->|"regulates"| SMURF1
    LGALS3["LGALS3"]
    LGALS3 -->|"interacts with"| SMURF1
    MTORC1["MTORC1"]
    MTORC1 -->|"inhibits"| SMURF1
    MTORC1 -->|"activates"| SMURF1
    style SMURF1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (40)

Target	Relation	Type	Str
UBIQUITIN	upstream_of	protein	0.85
Mycobacterium tuberculosis	protects_against	phenotype	0.80
M. tuberculosis	modifies	pathway	0.80
HOS1	inhibits	enzyme	0.80
Freezing Tolerance	associated_with	phenotype	0.80
AUTOPHAGY	activates	gene	0.70
Ms	activates	disease	0.65
Als	interacts_with	disease	0.65
Tumor	activates	disease	0.65
Hepatocellular Carcinoma	activates	disease	0.65
Carcinoma	activates	disease	0.65
Als	regulates	disease	0.65
Autophagy	activates	pathway	0.60
Mtor	inhibits	pathway	0.60
Autophagy	regulates	pathway	0.60
AUTOPHAGY	regulates	gene	0.60
MTORC1	activates	gene	0.60
CSNK1A1	regulates	gene	0.60
BECN1	activates	gene	0.60
UVRAG	activates	gene	0.60
Mtor	activates	pathway	0.60
RUBCN	activates	gene	0.60
NF-ΚB	activates	gene	0.60
APOPTOSIS	activates	gene	0.60
DDIT3	activates	gene	0.60
Nf-Κb	activates	pathway	0.60
Apoptosis	activates	pathway	0.60
Innate Immunity	activates	pathway	0.60
Immune Response	activates	pathway	0.60
UBIQUITIN	regulates	gene	0.60
LC3	regulates	gene	0.60
TFEB	activates	gene	0.60
autophagy pathway	participates_in	pathway	0.60
TFEB	regulates	gene	0.60
TFEB	inhibits	gene	0.60
MTOR	inhibits	gene	0.60
LGALS3	interacts_with	gene	0.60
CALCINEURIN	interacts_with	gene	0.60
PPP3	regulates	gene	0.60
PIK3C3	activates	gene	0.60

Incoming (19)

Source	Relation	Type	Str
MTORC1	activates	gene	0.60
BECN1	activates	gene	0.60
UVRAG	activates	gene	0.60
PRKN	associated_with	gene	0.60
AND	associated_with	gene	0.60
AND	activates	gene	0.60
PPP3	interacts_with	gene	0.60
PPP3CB	interacts_with	gene	0.60
PPP3	regulates	gene	0.60
LGALS3	activates	gene	0.60
PPP3CB	activates	gene	0.60
PIK3C3	activates	gene	0.60
RUBCN	activates	gene	0.60
MTOR	inhibits	gene	0.60
LYSOSOMAL BIOGENESIS	regulates	gene	0.60
LGALS3	interacts_with	gene	0.60
MTORC1	inhibits	gene	0.60
MAVS	activates	gene	0.60
UBIQUITIN	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning SMURF1 in their description or question text

No additional research found