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gene 790 words KG: RUBCN
Contents

RUBCN Gene

🧬 Gene Info
Gene SymbolRUBCN
FunctionVPS34/BECN1 complex inhibition: Rubicon directly binds the BECN1-VPS34-UVRAG-VPS15 complex (Class III PI3K complex II) through its RUN domain, suppressing VPS34 lipid kinase activity and reducing PI3P
PathwaysPI3K
Ensembl IDENSG00000145016
GeneCardsRUBCN
Human Protein AtlasRUBCN
Associated DiseasesAD, ADH, AMI, disease, Ischemia, Lupus
Known Drugs/Compoundsrapamycin
InteractionsACAT1, AMPK, AND, ATG, ATP, AUTOPHAGY
KG Connections344 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Knowledge Graph

Agent Input

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (15)

APOE-Dependent Autophagy Restoration
Score: 0.88CYP46A1 Overexpression Gene Therapy
Score: 0.73Autophagosome Maturation Checkpoint Control
Score: 0.71Perforant Path Presynaptic Terminal Protection Strategy
Score: 0.70Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69Cross-Seeding Prevention Strategy
Score: 0.69Lysosomal Positioning Dynamics Modulation
Score: 0.69Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67Mitochondrial-Lysosomal Contact Site Engineering
Score: 0.67The Mitochondrial-Lysosomal Metabolic Coupling Dysfunction
Score: 0.65Glycine-Rich Domain Competitive Inhibition
Score: 0.64FOXO3-Longevity Pathway Epigenetic Reprogramming
Score: 0.63TFEB-PGC1α Mitochondrial-Lysosomal Decoupling
Score: 0.62Cryptic Exon Silencing Restoration
Score: 0.53RNA-Binding Competition Therapy for TDP-43 Cross-Seeding
Score: 0.47

Related Analyses (4)

Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archivedNeuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archivedLipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completedCircuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (6)

PTEC-specific RUBCN knockout mice phenotyping
validation · proposed · Score: 0.90PTEC-specific RUBCN knockout mice phenotype analysis
validation · proposed · Score: 0.90RUBCN deficiency effects on lipid metabolism in isolated PTE
exploratory · proposed · Score: 0.85RUBCN deficiency effects on PTEC lipid metabolism
exploratory · proposed · Score: 0.85PTEC-hepatocyte co-culture fatty acid efflux study
exploratory · proposed · Score: 0.80

See Also (9)

ATP P2X3 Receptor Neurons
cell · KG edge: regulatesAMPK (AMP-Activated Protein Kinase)
entity · KG edge: activatesApoptosis in Neurodegeneration
entity · KG edge: associated_withAutophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: associated_withACTB Gene
gene · KG edge: regulates

Knowledge Graph (12 edges)

ACTB regulates RUBCN
PPARA regulates RUBCN
CAT regulates RUBCN
SQSTM1 regulates RUBCN
RPS6KB1 regulates RUBCN
RAB7A regulates RUBCN
SREBF1 regulates RUBCN
EIF4EBP1 regulates RUBCN
CTSD regulates RUBCN
PPARGC1A regulates RUBCN

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