gene

RAPTOR

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RAPTOR: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

112Connections

0Hypotheses

0Analyses

50Outgoing

36Incoming

0Experiments

0Debates

Summary

RAPTOR is a gene implicated in neurodegeneration research. Key relationships include: activates, expressed in, regulates. Associated with Als, Cancer, Carcinoma. Connected to 67 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	RAPTOR
Full Name	Regulatory Associated Protein of mTORC1
Aliases	Raptor protein
Chromosome	17q1.32
Function	RAPTOR (Regulatory-Associated Protein of mTOR) is an essential component of mTOR Complex 1 (mTORC1), serving as a scaffolding protein that recruits substrates to the mTOR kinase.
Primary Expression	the nervous system: - High expression: Cerebral cortex, hippocampus, basal forebrain - Mo
Molecular Weight	149 kDa
Pathways	mtor, mTOR, PI3K, AMPK
UniProt ID	Q8N122
Ensembl ID	ENSG00000141551
GeneCards	RAPTOR
Human Protein Atlas	RAPTOR
Associated Diseases	neurodegeneration
Interactions	ACETYL-COA, ACLY, ALPHA-SYNUCLEIN, AMPK, AND, ATG5
KG Connections	110 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: RAPTOR — AlphaFold Q8N122 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

RAPTOR Gene

gene · 547 words

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Pathway Diagram

graph TD
    RAPTOR["RAPTOR"]
    axonal_regeneration(["axonal regeneration"])
    RAPTOR -->|"regulates"| axonal_regeneration
    mTORC1["mTORC1"]
    RAPTOR -->|"interacts with"| mTORC1
    Ms{"Ms"}
    RAPTOR -->|"activates"| Ms
    Parkinson{"Parkinson"}
    RAPTOR -->|"activates"| Parkinson
    Hepatitis{"Hepatitis"}
    RAPTOR -->|"expressed in"| Hepatitis
    Cancer{"Cancer"}
    RAPTOR -->|"expressed in"| Cancer
    Carcinoma{"Carcinoma"}
    RAPTOR -->|"expressed in"| Carcinoma
    Cirrhosis{"Cirrhosis"}
    RAPTOR -->|"expressed in"| Cirrhosis
    RAPTOR -->|"expressed in"| Ms
    Tumor{"Tumor"}
    RAPTOR -->|"regulates"| Tumor
    RAPTOR -->|"inhibits"| Cancer
    RAPTOR -->|"inhibits"| Tumor
    AMPK["AMPK"]
    AMPK -->|"activates"| RAPTOR
    SNCA["SNCA"]
    SNCA -->|"activates"| RAPTOR
    MTOR["MTOR"]
    MTOR -->|"regulates"| RAPTOR
    P62["P62"]
    P62 -->|"regulates"| RAPTOR
    ULK1["ULK1"]
    ULK1 -->|"regulates"| RAPTOR
    CANCER["CANCER"]
    CANCER -->|"expressed in"| RAPTOR
    AUTOPHAGY["AUTOPHAGY"]
    AUTOPHAGY -->|"regulates"| RAPTOR
    MTOR -->|"inhibits"| RAPTOR
    UBIQUITIN["UBIQUITIN"]
    UBIQUITIN -->|"inhibits"| RAPTOR
    MTORC1["MTORC1"]
    MTORC1 -->|"inhibits"| RAPTOR
    CANCER -->|"inhibits"| RAPTOR
    AUTOPHAGY -->|"inhibits"| RAPTOR
    style RAPTOR fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (76)

Target	Relation	Type	Str
mTORC1	activates	pathway	0.85
mTORC1	interacts_with	protein	0.70
axonal regeneration	regulates	process	0.70
Carcinoma	expressed_in	disease	0.65
Cirrhosis	expressed_in	disease	0.65
Ms	expressed_in	disease	0.65
Tumor	regulates	disease	0.65
Als	interacts_with	disease	0.65
Renal Cell Carcinoma	therapeutic_target	disease	0.65
Lymphoma	therapeutic_target	disease	0.65
Carcinoma	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Cancer	inhibits	disease	0.65
Tumor	inhibits	disease	0.65
Ms	activates	disease	0.65
Als	regulates	disease	0.65
Parkinson	activates	disease	0.65
Cancer	interacts_with	disease	0.65
Cancer	activates	disease	0.65
Als	activates	disease	0.65
Cancer	expressed_in	disease	0.65
Hepatitis	expressed_in	disease	0.65
MTORC1	activates	protein	0.64
TBK1	activates	gene	0.60
USP9X	interacts_with	gene	0.60
Mtor	activates	pathway	0.60
Autophagy	activates	pathway	0.60
Autophagy	regulates	pathway	0.60
Mtor	regulates	pathway	0.60
Autophagy	inhibits	pathway	0.60
Mtor	inhibits	pathway	0.60
ALPHA-SYNUCLEIN	activates	gene	0.60
AUTOPHAGY	activates	gene	0.60
Alpha-Synuclein	activates	pathway	0.60
ACETYL-COA	activates	gene	0.60
ATP	activates	gene	0.60
PARKINSON	activates	gene	0.60
AMPK	activates	gene	0.60
PARKINSON'S DISEASE	activates	gene	0.60
APOPTOSIS	therapeutic_target	gene	0.60
BCL-2	expressed_in	gene	0.60
Mtor	expressed_in	pathway	0.60
Pi3K/Akt	therapeutic_target	pathway	0.60
Apoptosis	therapeutic_target	pathway	0.60
MTORC1	interacts_with	gene	0.60
CANCER	interacts_with	gene	0.60
Mtor	interacts_with	pathway	0.60
Neuron	activates	cell_type	0.60
Autophagy	methylates	pathway	0.60
Raf	activates	protein	0.60

Incoming (36)

Source	Relation	Type	Str
p300	modifies	protein	0.80
ACLY	activates	gene	0.60
SNCA	activates	gene	0.60
MTOR	regulates	gene	0.60
P62	regulates	gene	0.60
ULK1	regulates	gene	0.60
MTOR	inhibits	gene	0.60
UBIQUITIN	inhibits	gene	0.60
CANCER	expressed_in	gene	0.60
AUTOPHAGY	regulates	gene	0.60
MTORC1	inhibits	gene	0.60
CANCER	inhibits	gene	0.60
AUTOPHAGY	inhibits	gene	0.60
PARKINSON'S DISEASE	activates	gene	0.60
PARKINSON	activates	gene	0.60
MTORC1	regulates	gene	0.60
AND	regulates	gene	0.60
AND	interacts_with	gene	0.60
RAS	interacts_with	gene	0.60
ALPHA-SYNUCLEIN	activates	gene	0.60
MTORC1	methylates	gene	0.60
AUTOPHAGY	methylates	gene	0.60
ATP	activates	gene	0.60
ACETYL-COA	activates	gene	0.60
LYSOSOME	inhibits	gene	0.60
LKB1	activates	gene	0.60
AUTOPHAGY	activates	gene	0.60
MLST8	regulates	gene	0.60
ATG5	inhibits	gene	0.60
AND	inhibits	gene	0.60
AMPK	activates	gene	0.60
MTORC1	activates	gene	0.60
P300	regulates	protein	0.56
NEURON	co_discussed	gene	0.50
PARKIN	co_discussed	gene	0.50
Autophagy	activates	process	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning RAPTOR in their description or question text

No additional research found