gene

FOXP3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about FOXP3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

590Connections

0Hypotheses

2Analyses

50Outgoing

50Incoming

0Experiments

2Debates

Summary

FOXP3 is a gene implicated in neurodegeneration research. Key relationships include: regulates, associated with, activates. Associated with ALS, Aging, Als. Connected to 281 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	FOXP3
Full Name	FOXP3 (Forkhead Box P3)
Chromosome	Xp11.23
Protein Type	Transcription Factor
Target Class	Transcription Factor
Function	Transcription factor modulation - no direct small molecule binding
Mechanism of Action	Transcription factor modulation - no direct small molecule binding
Druggability	Low (0.35)
Clinical Stage	Phase I
Amino Acids	431 aa
Pathways	Apoptosis, Complement, Hedgehog, Immune Response, Mtor
UniProt ID	A0A494BZV0
GeneCards	FOXP3
Human Protein Atlas	FOXP3
Associated Diseases	Als, Alzheimer, Autoimmune, cancer
Known Drugs/Compounds	paeoniflorin, Paeoniflorin
Interactions	ACHE, ACOD1, AIF1, AKT, AMPK, AND
SciDEX Target	View Target Profile (2 clinical trials)
KG Connections	590 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: FOXP3 — AlphaFold A0A494BZV0 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

FOXP3 (Forkhead Box P3)

gene · 2204 words

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Pathway Diagram

graph TD
    FOXP3["FOXP3"] -->|"co discussed"| TNFA["TNFA"]
    FOXP3["FOXP3"] -->|"co discussed"| PPARGC1A["PPARGC1A"]
    FOXP3["FOXP3"] -->|"co discussed"| PRKAA1["PRKAA1"]
    FOXP3["FOXP3"] -->|"co discussed"| NR3C1["NR3C1"]
    FOXP3["FOXP3"] -->|"co discussed"| DRD2["DRD2"]
    FOXP3["FOXP3"] -->|"co discussed"| CHR2["CHR2"]
    TGFB1["TGFB1"] -->|"interacts"| FOXP3["FOXP3"]
    style FOXP3 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (411)

Target	Relation	Type	Str
Regulatory T cells	expressed_in	cell_type	0.95
CD4(+) T Cells	expressed_in	cell_type	0.95
Regulatory T Cell Differentiation	regulates	process	0.95
Regulatory T Cell	expressed_in	cell_type	0.95
macrophage phagocytosis	promotes	process	0.95
acute ischemic stroke	protects_against	disease	0.92
cargo metabolism	enhances	process	0.90
macrophage phagocytosis	enhances	process	0.90
cargo metabolism	regulates	process	0.90
immune_tolerance	maintains	phenotype	0.90
acute ischemic stroke	therapeutic_target	disease	0.87
cargo metabolism	promotes	process	0.87
Inflammation	activates	disease	0.85
Inflammation	regulates	disease	0.85
paeoniflorin	interacts_with	compound	0.85
immune response suppression	mediates	process	0.85
Als	activates	disease	0.85
Macrophage phagocytosis	facilitates	process	0.80
Als	inhibits	disease	0.75
NOTCH	activates	gene	0.70
STING	inhibits	gene	0.70
SQSTM1	activates	gene	0.70
NLRP3	activates	gene	0.70
PYCARD	activates	gene	0.70
OPTN	activates	gene	0.70
GSK3B	interacts_with	gene	0.70
STING	markers	gene	0.70
LRRK2	activates	gene	0.70
XIAP	activates	gene	0.70
IBA1	activates	gene	0.70
MACROPHAGE	expresses	cell_type	0.70
OLIGODENDROCYTE	activates	cell_type	0.70
LAMP1	interacts_with	gene	0.70
ULK1	activates	gene	0.70
STING	activates	gene	0.70
Immune Response	activates	pathway	0.70
IL-6	activates	gene	0.70
neural stem cells	expressed_in	cell_type	0.70
INFLAMMATION	regulates	gene	0.70
CD4	activates	gene	0.70
GENES	inhibits	gene	0.70
CD4	regulates	gene	0.70
Tumor	activates	disease	0.65
Ms	activates	disease	0.65
Carcinoma	expressed_in	disease	0.65
MTOR	activates	gene	0.65
Neuroinflammation	inhibits	disease	0.65
Cancer	therapeutic_target	disease	0.65
Multiple Sclerosis	activates	disease	0.65
Cancer	activates	disease	0.65

Incoming (179)

Source	Relation	Type	Str
h-6a065252	targets_gene	hypothesis	0.90
macroautophagy	modulates	process	0.85
macroautophagy	regulates	process	0.85
LC3	regulates	entity	0.85
Paeoniflorin	binds	compound	0.85
macroautophagy	inhibits	process	0.82
h-6a065252	targets	hypothesis	0.80
CD38	regulates	gene	0.70
CCL2	regulates	gene	0.70
CX3CR1	regulates	gene	0.70
CGAS	interacts_with	gene	0.70
BECN1	interacts_with	gene	0.70
AMPK	activates	gene	0.70
CCL2	expresses	gene	0.70
BECN1	activates	gene	0.70
ACHE	activates	gene	0.70
AIF1	activates	gene	0.70
CD4	activates	gene	0.70
INFLAMMATION	regulates	gene	0.70
STAT3	regulates	gene	0.60
MAP2K2	expressed_in	gene	0.60
ATM	expressed_in	gene	0.60
SYT1	regulates	gene	0.60
CX3CR1	associated_with	gene	0.60
HMOX1	regulates	gene	0.60
AKT	inhibits	gene	0.60
SYP	regulates	gene	0.60
CD8	expressed_in	gene	0.60
ACSL4	associated_with	gene	0.60
RELA	regulates	gene	0.60
MMP9	activates	gene	0.60
CD4	therapeutic_target	gene	0.60
JUN	regulates	gene	0.60
RORC	activates	gene	0.60
CD4	regulates	gene	0.60
RORA	associated_with	gene	0.60
BMP7	associated_with	gene	0.60
CD4	inhibits	gene	0.60
AHR	associated_with	gene	0.60
EP300	associated_with	gene	0.60
JUN	associated_with	gene	0.60
CD14	regulates	gene	0.60
P2RX3	regulates	gene	0.60
NLRP3	activates	gene	0.60
CD38	associated_with	gene	0.60
BAX	activates	gene	0.60
VIMENTIN	activates	gene	0.60
GATA3	activates	gene	0.60
TLR4	activates	gene	0.60
P2RY2	regulates	gene	0.60