concept

PHGDH

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PHGDH: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

184Connections

0Hypotheses

0Analyses

50Outgoing

37Incoming

0Experiments

0Debates

Summary

PHGDH is a concept in neurodegeneration research. Key relationships include: activates, therapeutic target, regulates. Associated with AD, AMI, ARM. Connected to 135 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	PHGDH
Key Genes/Proteins	ACAT1, AKT, ALZHEIMER'S DISEASE, AMBRA1, AND, APOE4
Related Diseases	AD, Aging, Als, Alzheimer, Alzheimer's disease
Related Pathways	Akt

Pathway Diagram

graph TD
    PHGDH["PHGDH"]
    PHGDH -->|"causes"| Alzheimer_s_disease["Alzheimer's disease"]
    PHGDH -->|"regulates"| Aging["Aging"]
    PHGDH -->|"regulates"| Ms["Ms"]
    PHGDH -->|"activates"| Cancer["Cancer"]
    PHGDH -->|"activates"| Tumor["Tumor"]
    PHGDH -->|"activates"| Als["Als"]
    PHGDH -->|"regulates"| Alzheimer["Alzheimer"]
    IDH1["IDH1"] -->|"upregulates"| PHGDH
    DDB1["DDB1"] -->|"binds"| PHGDH
    FASN["FASN"] -->|"activates"| PHGDH
    PRMT1["PRMT1"] -->|"activates"| PHGDH
    ERK["ERK"] -->|"activates"| PHGDH
    GAIN["GAIN"] -->|"activates"| PHGDH
    AKT["AKT"] -->|"target for"| PHGDH
    ELF3["ELF3"] -->|"activates"| PHGDH
    PI3K["PI3K"] -->|"activates"| PHGDH
    TP53["TP53"] -->|"activates"| PHGDH

Outgoing (147)

Target	Relation	Type	Str
methyl donor production	regulates	process	0.88
De Novo Fatty Acid Synthesis	involved_in	pathway	0.85
Liver Invasion	contributes_to	phenotype	0.85
Cancer	associated_with	disease	0.75
Cancer	activates	disease	0.75
Tumor	activates	disease	0.75
Als	activates	disease	0.75
Glycolysis	associated_with	pathway	0.70
CANCER	activates	gene	0.70
Als	inhibits	disease	0.65
Alzheimer	regulates	disease	0.65
Inflammation	regulates	disease	0.65
Tumor	therapeutic_target	disease	0.65
Colorectal Cancer	activates	disease	0.65
Tumor	associated_with	disease	0.65
Cancer	causes	disease	0.65
Ms	therapeutic_target	disease	0.65
Aging	methylates	disease	0.65
Als	regulates	disease	0.65
Cancer	expressed_in	disease	0.65
Ms	activates	disease	0.65
Cancer	therapeutic_target	disease	0.65
Heart Failure	therapeutic_target	disease	0.65
Ms	regulates	disease	0.65
Aging	regulates	disease	0.65
liver_invasion	activates	phenotype	0.64
PKM2	associated_with	gene	0.60
Rb	activates	protein	0.60
EIF2A	activates	gene	0.60
oxidative stress response	participates_in	pathway	0.60
stroke	inhibits	disease	0.60
stroke	targets	disease	0.60
Alzheimer's disease	activates	disease	0.60
NF-kB signaling	participates_in	pathway	0.60
ROS	activates	gene	0.60
Ubiquitin	activates	protein	0.60
pyroptosis	participates_in	pathway	0.60
neuroinflammation	associated_with	disease	0.60
Ras	associated_with	protein	0.60
ATG12	regulates	gene	0.60
ASNS	regulates	gene	0.60
astrocytes	expressed_in	cell_type	0.60
stroke	expressed_in	disease	0.60
Sumo	activates	protein	0.60
ELF3	activates	gene	0.60
stroke	associated_with	disease	0.60
MEIS1	activates	gene	0.60
Akt	activates	pathway	0.60
Pi3K	activates	pathway	0.60
Mapk	activates	pathway	0.60

Incoming (37)

Source	Relation	Type	Str
PRMT1	phosphorylates	protein	0.95
PRMT1	associated_with	gene	0.95
Prmt1-Dependent Methylation Of Phgdh At R54 Or R20	activates	mechanism	0.90
Prmt1-Dependent Methylation	activates	process	0.90
DDB1	binds	entity	0.80
IDH1	upregulates	gene	0.80
CANCER	activates	gene	0.60
AKT	therapeutic_target	gene	0.60
PRMT1	activates	gene	0.60
ERK	activates	gene	0.60
GAIN	activates	gene	0.60
ACAT1	associated_with	gene	0.60
GSH	activates	gene	0.60
NADPH	activates	gene	0.60
HMGB1	activates	gene	0.60
FASN	activates	gene	0.60
AKT	activates	gene	0.60
ERBB2	activates	gene	0.60
RAS	activates	gene	0.60
ACAT1	causes	gene	0.60
MEIS1	activates	gene	0.60
HK2	associated_with	gene	0.60
TP53	associated_with	gene	0.60
MTORC1	associated_with	gene	0.60
CANCER	associated_with	gene	0.60
GENES	associated_with	gene	0.60
PFKFB3	activates	gene	0.60
PKM2	associated_with	gene	0.60
PFKFB3	associated_with	gene	0.60
ELF3	activates	gene	0.60
PI3K	activates	gene	0.60
TP53	activates	gene	0.60
ERBB3	activates	gene	0.60
PKM2	regulates	protein	0.50
PFKFB3	regulates	protein	0.50
PKM2	activates	protein	0.50
cancer	causes	disease	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PHGDH in their description or question text

No additional research found