gene

SERPINE1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SERPINE1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

186Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

SERPINE1 is a gene implicated in neurodegeneration research. Key relationships include: therapeutic target, associated with, inhibits. Associated with Aging, Als, Carcinoma. Connected to 84 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	Serpin Family E Member 1 (PAI-1)
Chromosome	7q22.1
Function	is a 46 kDa glycoprotein that exists in three conformational states: active, latent, and cleaved.
Primary Expression	neurons, astrocytes, microglia, and endothelial cells within the brain
Molecular Weight	46 kDa
Amino Acids	402 aa
Pathways	Angiogenesis, Autophagy, Blood-Brain Barrier, Chaperone, Complement
UniProt ID	P05121
NCBI Gene ID	5054
Ensembl ID	ENSG00000105341
OMIM	173360
Synaptic Plasticity	PAI-1 modulates NMDA receptor signaling and affects long-term potentiation (LTP), with implications for memory formation. [@brown2021]
Neuroinflammation	Astrocyte and microglial PAI-1 production influences cytokine expression and immune cell trafficking
BBB Integrity	PAI-1 regulates pericyte function and endothelial-pericyte communication at the BBB. [@chen2022]
Neural Stem Cell Biology	The protein affects neurogenesis and neural progenitor cell migration
Associated Diseases	ALS, Alzheimer, Coagulopathy, Ischemia, schizophrenia
Known Drugs/Compounds	tiplaxtinin
Interactions	AGING, AKT, AND, ARSA, AUTOPHAGY, CCL2
KG Connections	186 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: SERPINE1 — AlphaFold P05121 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

SERPINE1 Gene

gene · 1458 words

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Pathway Diagram

flowchart TD
    SERPINE1["SERPINE1"] -->|"therapeutic target"| Inflammation["Inflammation"]
    SERPINE1["SERPINE1"] -->|"therapeutic target"| Ms["Ms"]
    SERPINE1["SERPINE1"] -->|"therapeutic target"| Stroke["Stroke"]
    SERPINE1["SERPINE1"] -->|"therapeutic target"| Ischemia["Ischemia"]
    SERPINE1["SERPINE1"] -->|"therapeutic target"| Carcinoma["Carcinoma"]
    SERPINE1["SERPINE1"] -->|"therapeutic target"| Als["Als"]
    SERPINE1["SERPINE1"] -->|"therapeutic target"| Tumor["Tumor"]
    SERPINE1["SERPINE1"] -->|"biomarker for"| Als["Als"]
    SERPINE1["SERPINE1"] -->|"biomarker for"| Ms["Ms"]
    SERPINE1["SERPINE1"] -->|"biomarker for"| Ischemia["Ischemia"]
    SERPINE1["SERPINE1"] -->|"contributes to"| Ms["Ms"]
    SERPINE1["SERPINE1"] -->|"expressed in"| Diabetes["Diabetes"]
    style SERPINE1 fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style Inflammation fill:#ef5350,stroke:#333,color:#e0e0e0
    style Ms fill:#ef5350,stroke:#333,color:#e0e0e0
    style Stroke fill:#ef5350,stroke:#333,color:#e0e0e0
    style Ischemia fill:#ef5350,stroke:#333,color:#e0e0e0
    style Carcinoma fill:#ef5350,stroke:#333,color:#e0e0e0
    style Als fill:#ef5350,stroke:#333,color:#e0e0e0
    style Tumor fill:#ef5350,stroke:#333,color:#e0e0e0
    style Diabetes fill:#ef5350,stroke:#333,color:#e0e0e0

Outgoing (122)

Target	Relation	Type	Str
p65	binds_to	protein	0.95
tumor progression	promotes	process	0.90
Plasmin Activation	inhibits	process	0.90
Coagulopathy	causes	phenotype	0.85
NF-ΚB	activates	pathway	0.85
Bipolar	activates	disease	0.65
Ischemia	associated_with	disease	0.65
Diabetes	activates	disease	0.65
Inflammation	expressed_in	disease	0.65
ALS	activates	disease	0.65
Stroke	therapeutic_target	disease	0.65
Ischemia	therapeutic_target	disease	0.65
Inflammation	activates	disease	0.65
Cardiovascular	activates	disease	0.65
Carcinoma	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Tumor	therapeutic_target	disease	0.65
Ulcerative Colitis	therapeutic_target	disease	0.65
Ms	contributes_to	disease	0.65
Aging	activates	disease	0.65
Fibrosis	activates	disease	0.65
Cardiovascular	expressed_in	disease	0.65
Ms	expressed_in	disease	0.65
Diabetes	expressed_in	disease	0.65
Melanoma	inhibits	disease	0.65
Als	biomarker_for	disease	0.65
Ms	biomarker_for	disease	0.65
Ischemia	biomarker_for	disease	0.65
Senescence	activates	disease	0.65
ALS	associated_with	disease	0.65
Alzheimer	expressed_in	disease	0.65
Als	contributes_to	disease	0.65
Neuroinflammation	expressed_in	disease	0.65
Als	activates	disease	0.65
Schizophrenia	activates	disease	0.65
Neuroinflammation	activates	disease	0.65
Ms	therapeutic_target	disease	0.65
Inflammation	therapeutic_target	disease	0.65
ESR1	therapeutic_target	gene	0.60
APOA1	therapeutic_target	gene	0.60
Angiogenesis	inhibits	pathway	0.60
RAGE	therapeutic_target	gene	0.60
PPARGC1A	therapeutic_target	gene	0.60
Transferrin	activates	protein	0.60
PON1	therapeutic_target	gene	0.60
CYTOKINES	therapeutic_target	gene	0.60
INFLAMMATION	therapeutic_target	gene	0.60
Lipid Metabolism	expressed_in	pathway	0.60
P2RX7	contributes_to	gene	0.60
HSPA1B	associated_with	gene	0.60

Incoming (64)

Source	Relation	Type	Str
BMAL1	upregulates	gene	0.90
senescent tumor cells	expressed_in	cell_type	0.90
tiplaxtinin	inhibits	drug	0.85
STAT3	upregulates	protein	0.85
Acute Lung Injury	upregulates	disease	0.75
RAGE	therapeutic_target	gene	0.60
JAK3	therapeutic_target	gene	0.60
PPARGC1A	therapeutic_target	gene	0.60
APOA1	therapeutic_target	gene	0.60
P2RX7	contributes_to	gene	0.60
VEGFA	activates	gene	0.60
LNCRNA	expressed_in	gene	0.60
HMOX1	associated_with	gene	0.60
AND	inhibits	gene	0.60
AND	activates	gene	0.60
GENES	contributes_to	gene	0.60
NEUROINFLAMMATION	expressed_in	gene	0.60
ALZHEIMER	expressed_in	gene	0.60
RNA	contributes_to	gene	0.60
INFLAMMATION	activates	gene	0.60
NEUROINFLAMMATION	activates	gene	0.60
HSPA1B	associated_with	gene	0.60
PER	therapeutic_target	gene	0.60
RNA	interacts_with	gene	0.60
APP/PS1	expressed_in	gene	0.60
ICAM1	inhibits	gene	0.60
MMP9	inhibits	gene	0.60
SPP1	inhibits	gene	0.60
NOS2	inhibits	gene	0.60
PTGS2	inhibits	gene	0.60
MMP2	inhibits	gene	0.60
MMP3	associated_with	gene	0.60
STAT3	associated_with	gene	0.60
PTGS2	associated_with	gene	0.60
IGF1	contributes_to	gene	0.60
ACE	regulates	gene	0.60
MMP2	regulates	gene	0.60
PPARG	regulates	gene	0.60
LRP1	associated_with	gene	0.60
APP	expressed_in	gene	0.60
EGFR	contributes_to	gene	0.60
P2RX7	biomarker_for	gene	0.60
INFLAMMATION	therapeutic_target	gene	0.60
APOPTOSIS	therapeutic_target	gene	0.60
OXIDATIVE STRESS	therapeutic_target	gene	0.60
HIF	associated_with	gene	0.60
CYTOKINES	inhibits	gene	0.60
CYTOKINES	therapeutic_target	gene	0.60
PON1	therapeutic_target	gene	0.60
IGF1	therapeutic_target	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning SERPINE1 in their description or question text

No additional research found