gene

SOD2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SOD2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

820Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

SOD2 is a gene implicated in neurodegeneration research. Key relationships include: associated with, activates, regulates. Associated with ALZHEIMER, ALZHEIMER'S, ALZHEIMER'S DISEASE. Connected to 454 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	SOD2
Full Name	Superoxide Dismutase 2, Mitochondrial
Chromosome	6q25.3
Function	SOD2 provides essential mitochondrial antioxidant defense
Molecular Weight	22.3 kDa
Amino Acids	222 aa
Exons	5
Pathways	Akt, Apoptosis, Mapk, Mitochondrial Function, Mtor
NCBI Gene ID	6648
Ensembl ID	ENSG00000112096
OMIM	147460
GeneCards	SOD2
Human Protein Atlas	SOD2
Associated Diseases	Aging, Als, Alzheimer, Amyotrophic Lateral Sclerosis, Cancer
Known Drugs/Compounds	berberine, BERBERINE, Lactiplantibacillus plantarum FRT4, resveratrol, RESVERATROL
Interactions	ACHE, AD, AGING, AKT, ALZHEIMER, ALZHEIMER'S DISEASE
KG Connections	820 knowledge graph edges
Databases	GeneCards UniProt HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

SOD2 Gene

gene · 766 words

→

SOD2 Protein

protein · 1030 words

→

Pathway Diagram

graph TD
    SOD2["SOD2"] -->|"Degrades"| superoxide_anion["superoxide anion"]
    SOD2["SOD2"] -->|"Therapeutic Target"| Cancer["Cancer"]
    SOD2["SOD2"] -->|"Therapeutic Target"| Ms["Ms"]
    SOD2["SOD2"] -->|"Therapeutic Target"| Parkinson["Parkinson"]
    SOD2["SOD2"] -->|"Therapeutic Target"| Inflammation["Inflammation"]
    SOD2["SOD2"] -->|"Therapeutic Target"| Diabetes["Diabetes"]
    SOD2["SOD2"] -->|"Inhibits"| Cardiovascular["Cardiovascular"]
    SOD2["SOD2"] -->|"Inhibits"| Als["Als"]
    Lactiplantibacillus_plantarum_["Lactiplantibacillus plantarum FRT4"] -->|"Activates"| SOD2["SOD2"]
    FOXO1["FOXO1"] -->|"Activates"| SOD2["SOD2"]
    MET["MET"] -->|"Therapeutic Target"| SOD2["SOD2"]
    TPM2["TPM2"] -->|"Therapeutic Target"| SOD2["SOD2"]
    PANX1["PANX1"] -->|"Regulates"| SOD2["SOD2"]
    style SOD2 fill:#8d4900,color:#e0e0e0
    style superoxide_anion fill:#607D8B,color:#e0e0e0
    style Cancer fill:#b71c1c,color:#e0e0e0
    style Ms fill:#b71c1c,color:#e0e0e0
    style Parkinson fill:#b71c1c,color:#e0e0e0
    style Inflammation fill:#b71c1c,color:#e0e0e0
    style Diabetes fill:#b71c1c,color:#e0e0e0
    style Cardiovascular fill:#b71c1c,color:#e0e0e0
    style Als fill:#b71c1c,color:#e0e0e0
    style Lactiplantibacillus_plantarum_ fill:#00838f,color:#e0e0e0
    style FOXO1 fill:#8d4900,color:#e0e0e0
    style MET fill:#8d4900,color:#e0e0e0
    style TPM2 fill:#8d4900,color:#e0e0e0
    style PANX1 fill:#8d4900,color:#e0e0e0

Outgoing (447)

Target	Relation	Type	Str
superoxide anion	inhibits	phenotype	0.95
mitochondrial reactive oxygen species	inhibits	process	0.94
Parkinson	associated_with	disease	0.75
Als	associated_with	disease	0.75
Als	activates	disease	0.75
Inflammation	activates	disease	0.75
Aging	activates	disease	0.75
Fibrosis	activates	disease	0.75
SQSTM1	activates	gene	0.70
SQSTM1	interacts_with	gene	0.70
TNF-Α	inhibits	gene	0.70
MITOCHONDRIAL DYSFUNCTION	activates	gene	0.70
FOXO1	activates	gene	0.70
Oxidative Stress	inhibits	pathway	0.70
Mtor	expressed_in	pathway	0.70
Oxidative Stress	activates	pathway	0.70
TNF	inhibits	gene	0.70
Nf-Κb	inhibits	pathway	0.70
NRF2	expressed_in	gene	0.70
Tgf-Β	inhibits	pathway	0.70
Apoptosis	activates	pathway	0.70
Oxidative Stress	protects_against	pathway	0.70
NF-ΚB	inhibits	gene	0.70
Hypertension	protects_against	disease	0.65
Cardiovascular	inhibits	disease	0.65
Tumor	activates	disease	0.65
Neuroinflammation	activates	disease	0.65
Diabetes	activates	disease	0.65
Inflammation	associated_with	disease	0.65
Als	regulates	disease	0.65
Atherosclerosis	protects_against	disease	0.65
Ms	expressed_in	disease	0.65
Fibrosis	therapeutic_target	disease	0.65
Aging	therapeutic_target	disease	0.65
Atherosclerosis	activates	disease	0.65
Carcinoma	expressed_in	disease	0.65
Huntington	activates	disease	0.65
Alzheimer	activates	disease	0.65
Inflammation	inhibits	disease	0.65
Cancer	activates	disease	0.65
Hypertension	inhibits	disease	0.65
Fibrosis	inhibits	disease	0.65
Cancer	therapeutic_target	disease	0.65
Cirrhosis	expressed_in	disease	0.65
Als	interacts_with	disease	0.65
Ms	associated_with	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Diabetes	inhibits	disease	0.65
Diabetes	therapeutic_target	disease	0.65
Parkinson	therapeutic_target	disease	0.65

Incoming (373)

Source	Relation	Type	Str
MN	downregulates	compound	0.95
Sirt3	regulates	protein	0.92
URG7	upregulates	enzyme	0.92
STAT3	regulates	gene	0.90
FOXO1	upregulates	gene	0.90
SIRT3	mediates	gene	0.85
PM10	downregulates	compound	0.80
Lactiplantibacillus plantarum FRT4	activates	drug	0.80
LAMP1	activates	gene	0.70
APOE	expresses	gene	0.70
FGF	activates	gene	0.70
NRF2	mediates	gene	0.70
ATG7	activates	gene	0.70
OLIGODENDROCYTE	activates	cell_type	0.70
ATG5	activates	gene	0.70
CNP	activates	gene	0.70
GFAP	activates	gene	0.70
MBP	activates	gene	0.70
PINK1	activates	gene	0.70
OLIGODENDROCYTES	activates	cell_type	0.70
CAT	regulates	gene	0.70
NRF2	interacts_with	gene	0.70
GPX4	activates	gene	0.70
PARP1	activates	gene	0.70
SIRT1	activates	gene	0.70
PARP1	expresses	gene	0.70
HSPA1A	activates	gene	0.70
SIRT1	expresses	gene	0.70
HSP90	activates	gene	0.70
PARKINSON	associated_with	gene	0.70
BAX	expressed_in	gene	0.70
SIRT3	protects_against	gene	0.70
MTOR	inhibits	gene	0.70
ROS	inhibits	gene	0.70
MACROPHAGE	activates	cell_type	0.65
NLRP3	inhibits	gene	0.65
SIRT1	associated_with	gene	0.65
BECN1	associated_with	gene	0.65
NRF2	associated_with	gene	0.65
PINK1	associated_with	gene	0.65
AKT	associated_with	gene	0.65
RESVERATROL	regulates	drug	0.65
SOD1	regulates	gene	0.65
AUTOPHAGY	associated_with	gene	0.65
AMPK	associated_with	gene	0.65
MITOCHONDRIA	associated_with	gene	0.65
PANX1	regulates	gene	0.60
S100B	regulates	gene	0.60
RELB	regulates	gene	0.60
P2RY1	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning SOD2 in their description or question text

No additional research found