gene

STAT6

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about STAT6: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

320Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

Comprehensive coverage of STAT6 in cytokine signaling, immune function, neuroinflammation, and implications for Alzheimer's disease, Parkinson's disease, and other neurodegenerative disorders.

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🧬 Gene Info

Gene Symbol	STAT6
Full Name	Signal Transducer and Activator of Transcription 6
Chromosome	12q13.3
Protein Type	Transcription Factor
Function	is a transcription factor activated specifically by interleukin-4 (IL-4) and interleukin-13 (IL-13) receptor signaling.
Amino Acids	847 aa
Gene Type	Protein coding
Pathways	Akt, Apoptosis, Blood-Brain Barrier, Differentiation, Dna Repair
UniProt ID	P42262
NCBI Gene ID	6778
Ensembl ID	ENSG00000141510
OMIM	601512
GeneCards	STAT6
Human Protein Atlas	STAT6
Associated Diseases	Als, Asthma, Inflammation, Neuroinflammation
Known Drugs/Compounds	BENVITIMOD, curcumin, Curcumin
Interactions	AGING, AHR, AKT, AND, APOPTOSIS, ARNT
KG Connections	320 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: STAT6 — AlphaFold P42262 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

STAT6 — Signal Transducer and Activator of Transcription 6

gene · 2160 words

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Pathway Diagram

graph TD
    STAT6["STAT6"]
    STAT6 -->|"inhibits"| Als["Als"]
    STAT6 -->|"activates"| Cancer["Cancer"]
    STAT6 -->|"activates"| Carcinoma["Carcinoma"]
    STAT6 -->|"activates"| Tumor["Tumor"]
    STAT6 -->|"expressed in"| Ms["Ms"]
    STAT6 -->|"activates"| Neuroinflammation["Neuroinflammation"]
    STAT6 -->|"activates"| Inflammation["Inflammation"]
    BENVITIMOD["BENVITIMOD"] -->|"inhibits"| STAT6
    HDAC5["HDAC5"] -->|"regulates"| STAT6
    CLDN1["CLDN1"] -->|"inhibits"| STAT6
    NRF2["NRF2"] -->|"inhibits"| STAT6
    ARNT["ARNT"] -->|"activates"| STAT6
    AHR["AHR"] -->|"activates"| STAT6
    OCLN["OCLN"] -->|"inhibits"| STAT6
    SLC7A11["SLC7A11"] -->|"activates"| STAT6
    CLDN4["CLDN4"] -->|"inhibits"| STAT6

Outgoing (188)

Target	Relation	Type	Str
SLC7A11	upregulates	gene	0.95
DNA repair	promotes	process	0.92
homologous recombination	activates	pathway	0.88
Inflammation	activates	disease	0.85
Als	activates	disease	0.75
Carcinoma	activates	disease	0.75
Tumor	activates	disease	0.75
Nf-Κb	activates	pathway	0.70
Als	inhibits	disease	0.65
Cancer	activates	disease	0.65
Aging	activates	disease	0.65
Inflammation	causes	disease	0.65
ALS	causes	disease	0.65
Cancer	inhibits	disease	0.65
Stroke	protects_against	disease	0.65
Als	regulates	disease	0.65
Inflammation	inhibits	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Parkinson	therapeutic_target	disease	0.65
Depression	therapeutic_target	disease	0.65
Tumor	inhibits	disease	0.65
Neuroinflammation	implicated_in	disease	0.65
Ms	contributes_to	disease	0.65
Inflammation	expressed_in	disease	0.65
Asthma	causes	disease	0.65
Als	causes	disease	0.65
Senescence	protects_against	disease	0.65
Ischemia	activates	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Neuroinflammation	expressed_in	disease	0.65
Ms	expressed_in	disease	0.65
Neuroinflammation	activates	disease	0.65
Inflammation	regulates	disease	0.65
Anxiety	therapeutic_target	disease	0.65
ALS	inhibits	disease	0.65
Als	contributes_to	disease	0.65
Inflammation	contributes_to	disease	0.65
Ms	therapeutic_target	disease	0.65
Stroke	therapeutic_target	disease	0.65
Tumor	regulates	disease	0.65
Epilepsy	therapeutic_target	disease	0.65
Addiction	therapeutic_target	disease	0.65
Glioblastoma	activates	disease	0.65
SLC7A11	activates	gene	0.64
STAT1	inhibits	gene	0.60
SOCS1	inhibits	gene	0.60
JUN	activates	gene	0.60
STAT3	inhibits	gene	0.60
JAK2	inhibits	gene	0.60
NRF2	therapeutic_target	gene	0.60

Incoming (132)

Source	Relation	Type	Str
HDAC5	associated_with	gene	0.90
Curcumin	activates	drug	0.85
P38	activates	gene	0.70
AKT	activates	gene	0.70
NF-ΚB	activates	gene	0.70
INFLAMMATION	activates	gene	0.70
HDAC5	regulates	protein	0.64
BENVITIMOD	inhibits	drug	0.64
ASTROCYTE	therapeutic_target	gene	0.60
AGING	activates	gene	0.60
AND	associated_with	gene	0.60
GENES	activates	gene	0.60
IL-13	activates	gene	0.60
JAK	inhibits	gene	0.60
JAK	causes	gene	0.60
DNA	activates	gene	0.60
RNA	activates	gene	0.60
SIK1	activates	gene	0.60
TNF-Α	expressed_in	gene	0.60
BDNF	associated_with	gene	0.60
TNF	therapeutic_target	gene	0.60
SOD1	associated_with	gene	0.60
CLDN1	inhibits	gene	0.60
NRF2	inhibits	gene	0.60
ARNT	activates	gene	0.60
AHR	activates	gene	0.60
OCLN	inhibits	gene	0.60
SLC7A11	activates	gene	0.60
HDAC5	activates	gene	0.60
JAK3	expressed_in	gene	0.60
DEPRESSION	therapeutic_target	gene	0.60
NPY	associated_with	gene	0.60
STROKE	therapeutic_target	gene	0.60
AND	inhibits	gene	0.60
NPY1R	associated_with	gene	0.60
MTOR	activates	gene	0.60
TNF	activates	gene	0.60
DVL2	therapeutic_target	gene	0.60
ALZHEIMER	therapeutic_target	gene	0.60
VEGF	associated_with	gene	0.60
PI3K	therapeutic_target	gene	0.60
AKT	therapeutic_target	gene	0.60
STAT1	expressed_in	gene	0.60
NQO1	associated_with	gene	0.60
GAIN	expressed_in	gene	0.60
SIRT1	therapeutic_target	gene	0.60
TAU	associated_with	gene	0.60
ACSL4	associated_with	gene	0.60
FOXP3	inhibits	gene	0.60
IL-4	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning STAT6 in their description or question text

No additional research found