protein

FOS

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about FOS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

492Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

FOS is a protein involved in neurodegeneration research. Key relationships include: activates, regulates, therapeutic target. Associated with ALS, Aging, Als. Connected to 326 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	FOS
Full Name	FBJ Murine Osteosarcoma Viral Oncogene Homolog
Chromosome	14q24.3
Protein Type	Transcription Factor
Function	FOS is an immediate-early gene encoding a leucine zipper transcription factor.
Molecular Weight	40.6 kDa
Pathways	Immune Response, Neurogenesis, Nf-Kb, Nf-Κb, Synaptic Plasticity
UniProt ID	P01100
NCBI Gene ID	2353
Ensembl ID	ENSG00000170345
OMIM	164810
GeneCards	FOS
Human Protein Atlas	FOS
Activity-dependent transcription	Responds to neuronal firing and calcium influx
AP-1 complex formation	Heterodimers with JUN family proteins (c-JUN, JUNB, JUND)
Associated Diseases	Als, Alzheimer, Atherosclerosis, Cancer, Ischemia, Ms
Known Drugs/Compounds	pokeweed mitogen
Interactions	Actin, AKT1, ALZHEIMER, ALZHEIMER'S DISEASE, AND, ANXIETY
KG Connections	492 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: FOS — AlphaFold P01100 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (4)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    FOS["FOS"]
    FOS -->|"activates"| Cancer["Cancer"]
    FOS -->|"activates"| Als["Als"]
    FOS -->|"interacts"| Inflammation["Inflammation"]
    FOS -->|"interacts"| Ms["Ms"]
    FOS -->|"contributes to"| Anxiety["Anxiety"]
    pokeweed_mitogen["pokeweed mitogen"] -->|"activates"| FOS
    EGF["EGF"] -->|"activates"| FOS
    PIEZO1["PIEZO1"] -->|"activates"| FOS
    SRC["SRC"] -->|"activates"| FOS
    EGFR["EGFR"] -->|"activates"| FOS
    JUN["JUN"] -->|"activates"| FOS
    P38["P38"] -->|"activates"| FOS
    ERK["ERK"] -->|"activates"| FOS

Outgoing (388)

Target	Relation	Type	Str
Retinal Neuronal Apoptosis	regulates	process	0.85
Inflammation	activates	disease	0.85
JUN	activates	gene	0.80
Als	activates	disease	0.75
Aging	regulates	disease	0.75
Als	expressed_in	disease	0.75
Als	regulates	disease	0.75
C-FOS	regulates	gene	0.70
OXIDATIVE STRESS	activates	gene	0.70
C-FOS	activates	gene	0.70
BDNF	activates	gene	0.70
IL-6	activates	gene	0.70
Oxidative Stress	activates	pathway	0.70
GENES	activates	gene	0.70
ARC	activates	gene	0.70
CYTOKINES	activates	gene	0.70
C-FOS	expressed_in	gene	0.70
JUN	regulates	gene	0.70
INFLAMMATION	activates	gene	0.70
TNF-Α	activates	gene	0.70
STAT3	activates	gene	0.70
Als	associated_with	disease	0.65
Inflammation	regulates	disease	0.65
Ms	activates	disease	0.65
Pneumonia	regulates	disease	0.65
Anxiety	contributes_to	disease	0.65
Inflammation	interacts_with	disease	0.65
Depression	activates	disease	0.65
Neurodegeneration	regulates	disease	0.65
Neuroinflammation	activates	disease	0.65
Asthma	treats	disease	0.65
Ms	interacts_with	disease	0.65
Alzheimer	inhibits	disease	0.65
neurotrophin signaling	participates_in	pathway	0.65
Ms	associated_with	disease	0.65
synaptic plasticity	participates_in	pathway	0.65
Cancer	activates	disease	0.65
Depression	therapeutic_target	disease	0.65
Neurodegeneration	activates	disease	0.65
Neuroinflammation	associated_with	disease	0.65
Anxiety	activates	disease	0.65
Obesity	activates	disease	0.65
Anxiety	therapeutic_target	disease	0.65
Senescence	therapeutic_target	disease	0.65
Parkinson	activates	disease	0.65
Aging	activates	disease	0.65
Senescence	activates	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
ALS	activates	disease	0.65
Alzheimer	associated_with	disease	0.65

Incoming (104)

Source	Relation	Type	Str
pokeweed mitogen	activates	drug	0.90
ARC	activates	gene	0.75
NF-ΚB	activates	gene	0.60
IFN	activates	gene	0.60
OXIDATIVE STRESS	activates	gene	0.60
IL-6	activates	gene	0.60
IFN-Γ	activates	gene	0.60
HO-1	inhibits	gene	0.60
GENES	associated_with	gene	0.60
CCL2	associated_with	gene	0.60
ALZHEIMER	associated_with	gene	0.60
NEUROTOXICITY	activates	gene	0.60
AKT1	associated_with	gene	0.60
TNF	activates	gene	0.60
MAPK1	activates	gene	0.60
CREB1	activates	gene	0.60
NTRK3	activates	gene	0.60
EGR1	activates	gene	0.60
CD4	therapeutic_target	gene	0.60
GJA1	associated_with	gene	0.60
CD4	associated_with	gene	0.60
TLR4	activates	gene	0.60
APOE	regulates	gene	0.60
CYTOKINES	activates	gene	0.60
AGING	therapeutic_target	gene	0.60
VIRAL INFECTIONS	activates	gene	0.60
IL-6	associated_with	gene	0.60
CANCER	therapeutic_target	gene	0.60
OXIDATIVE STRESS	therapeutic_target	gene	0.60
C-FOS	associated_with	gene	0.60
C-FOS	activates	gene	0.60
TSLP	regulates	gene	0.60
NEURODEGENERATION	regulates	gene	0.60
INFLAMMATION	activates	gene	0.60
AND	activates	gene	0.60
CIRCADIAN RHYTHM	activates	gene	0.60
ALZHEIMER	therapeutic_target	gene	0.60
NEUROINFLAMMATION	activates	gene	0.60
C-FOS	regulates	gene	0.60
GENES	regulates	gene	0.60
CCL2	targets	gene	0.60
MAPK12	therapeutic_target	gene	0.60
AGING	regulates	gene	0.60
JUN	interacts_with	gene	0.60
STAT3	interacts_with	gene	0.60
BCL2	therapeutic_target	gene	0.60
PLIN2	activates	gene	0.60
BMAL1	activates	gene	0.60
SIRT1	activates	gene	0.60
NRF2	inhibits	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning FOS in their description or question text

No additional research found

FOS