gene

CCL20

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CCL20: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

155Connections

0Hypotheses

0Analyses

50Outgoing

41Incoming

0Experiments

0Debates

Summary

CCL20 is a gene implicated in neurodegeneration research. Key relationships include: associated with, activates, regulates. Associated with ALS, Als, Alzheimer. Connected to 78 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	CCL20
Chromosome	2q36.3
Protein Type	Chemokine
Function	CCL20 has distinct functions in immune and nervous systems:
Primary Expression	CCR6 is expressed on Th17 cells, regulatory T cells, B cells, and dendritic cells
Molecular Weight	8 kDa
Pathways	PI3K, MAPK
NCBI Gene ID	6384
GeneCards	CCL20
Human Protein Atlas	CCL20
Associated Diseases	Als, Alzheimer, Autoimmune, Cancer, Carcinoma, Diabetes
Known Drugs/Compounds	IRN
Interactions	AND, C1QA, CANCER, CCR6, CEBPB, Chemokine
KG Connections	155 knowledge graph edges
Databases	GeneCards UniProt HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

CCL20 Gene

gene · 615 words

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Pathway Diagram

flowchart TD
    IRN["IRN"] -.->|"inhibits"| CCL20["CCL20"]
    CCL20["CCL20"] -->|"therapeutic target"| Ms["Ms"]
    CCL20["CCL20"] -->|"therapeutic target"| Als["Als"]
    CCL20["CCL20"] -->|"regulates"| Als["Als"]
    CCL20["CCL20"] -->|"regulates"| Neuroinflammation["Neuroinflammation"]
    CCL20["CCL20"] -->|"regulates"| Inflammation["Inflammation"]
    CCL20["CCL20"] -->|"associated with"| Hepatitis["Hepatitis"]
    CCL20["CCL20"] -->|"associated with"| Glioblastoma["Glioblastoma"]
    CCL20["CCL20"] -->|"associated with"| Alzheimer["Alzheimer"]
    CCL20["CCL20"] -->|"associated with"| Obesity["Obesity"]
    CCL20["CCL20"] -->|"associated with"| Diabetes["Diabetes"]
    CCL20["CCL20"] -->|"associated with"| Stroke["Stroke"]
    style IRN fill:#6d3000,stroke:#333,color:#e0e0e0
    style CCL20 fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style Ms fill:#ef5350,stroke:#333,color:#e0e0e0
    style Als fill:#ef5350,stroke:#333,color:#e0e0e0
    style Neuroinflammation fill:#ef5350,stroke:#333,color:#e0e0e0
    style Inflammation fill:#ef5350,stroke:#333,color:#e0e0e0
    style Hepatitis fill:#ef5350,stroke:#333,color:#e0e0e0
    style Glioblastoma fill:#ef5350,stroke:#333,color:#e0e0e0
    style Alzheimer fill:#ef5350,stroke:#333,color:#e0e0e0
    style Obesity fill:#ef5350,stroke:#333,color:#e0e0e0
    style Diabetes fill:#ef5350,stroke:#333,color:#e0e0e0
    style Stroke fill:#ef5350,stroke:#333,color:#e0e0e0

Outgoing (114)

Target	Relation	Type	Str
Subarachnoid Hemorrhage	associated_with	disease	0.80
NF-ΚB	activates	gene	0.70
Nf-Κb	activates	pathway	0.70
Colorectal Cancer	activates	disease	0.65
Fibrosis	associated_with	disease	0.65
Cancer	activates	disease	0.65
ALS	expressed_in	disease	0.65
Ms	therapeutic_target	disease	0.65
Alzheimer	associated_with	disease	0.65
Leukemia	associated_with	disease	0.65
Inflammation	regulates	disease	0.65
Aging	activates	disease	0.65
Tumor	inhibits	disease	0.65
Stroke	associated_with	disease	0.65
Als	associated_with	disease	0.65
Als	regulates	disease	0.65
Cancer	expressed_in	disease	0.65
Carcinoma	associated_with	disease	0.65
Neuroinflammation	regulates	disease	0.65
Cancer	therapeutic_target	disease	0.65
Autoimmune	associated_with	disease	0.65
Glioblastoma	associated_with	disease	0.65
Cardiovascular	expressed_in	disease	0.65
Hepatitis	associated_with	disease	0.65
Obesity	associated_with	disease	0.65
Als	therapeutic_target	disease	0.65
Diabetes	associated_with	disease	0.65
Cancer	associated_with	disease	0.65
Als	activates	disease	0.65
Inflammation	activates	disease	0.65
Ms	associated_with	disease	0.65
Multiple Sclerosis	associated_with	disease	0.65
INFLAMMATION	activates	gene	0.60
CYTOKINES	activates	gene	0.60
CYTOKINES	therapeutic_target	gene	0.60
Notch	associated_with	pathway	0.60
Complement	activates	pathway	0.60
T Cell	activates	cell_type	0.60
NEUROINFLAMMATION	regulates	gene	0.60
ASTROCYTES	regulates	gene	0.60
Macrophage	activates	cell_type	0.60
Monocyte	activates	cell_type	0.60
Stem Cell	activates	cell_type	0.60
Microglia	activates	cell_type	0.60
AND	activates	gene	0.60
Dendritic Cell	activates	cell_type	0.60
INFLAMMATION	regulates	gene	0.60
CANCER	expressed_in	gene	0.60
Chemoresistance	interacts_with	pathway	0.60
Tumor Microenvironment	activates	pathway	0.60

Incoming (41)

Source	Relation	Type	Str
ABLIM1	upstream_of	protein	0.90
Isorhynchophylline	downregulates	compound	0.90
NF-KB	regulates	pathway	0.90
IRN	inhibits	drug	0.72
FOXO1	activates	gene	0.60
CXCL8	associated_with	gene	0.60
MMP3	associated_with	gene	0.60
ICAM1	associated_with	gene	0.60
HMGCR	therapeutic_target	gene	0.60
RNA	therapeutic_target	gene	0.60
GENES	associated_with	gene	0.60
RNA	expressed_in	gene	0.60
AND	associated_with	gene	0.60
TLR4	activates	gene	0.60
C1QA	activates	gene	0.60
RNA	activates	gene	0.60
GENES	therapeutic_target	gene	0.60
MIRNAS	activates	gene	0.60
RORA	associated_with	gene	0.60
BMP7	associated_with	gene	0.60
CX3CR1	associated_with	gene	0.60
AHR	associated_with	gene	0.60
EP300	associated_with	gene	0.60
JUN	associated_with	gene	0.60
JAK2	associated_with	gene	0.60
STAT3	activates	gene	0.60
SOCS3	activates	gene	0.60
AND	activates	gene	0.60
CYTOKINES	associated_with	gene	0.60
DIABETES MELLITUS	associated_with	gene	0.60
CANCER	associated_with	gene	0.60
GENES	expressed_in	gene	0.60
LRP1	activates	gene	0.60
MICRORNAS	associated_with	gene	0.60
CYTOKINES	activates	gene	0.60
MMP9	activates	gene	0.60
IL6	activates	gene	0.60
ICAM1	expressed_in	gene	0.50
C1QA	co_discussed	gene	0.50
RNA	regulates	gene	0.50
ICAM1	interacts_with	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CCL20 in their description or question text

No additional research found