gene

FGF21

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about FGF21: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

501Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

FGF21 encodes a metabolic regulator of the FGF19 subfamily with emerging roles in neuroprotection, neuroinflammation, synaptic plasticity, and potential therapeutic applications in Alzheimer's and Parkinson's diseases.

View on Wiki →

No AI portrait yet

🧬 Gene Info

Gene Symbol	FGF21
Full Name	Fibroblast Growth Factor 21
Chromosome	12q13
Function	encodes a member of the FGF19 subfamily of fibroblast growth factors that functions primarily as a metabolic regulator.
Molecular Weight	22.5 kDa
Amino Acids	209 aa
Pathways	Apoptosis, Autophagy, Mtor
UniProt ID	Q9NS73
NCBI Gene ID	26291
Ensembl ID	ENSG00000163410
OMIM	609436
GeneCards	FGF21
Human Protein Atlas	FGF21
Associated Diseases	Aging, Als, Alzheimer, Amyotrophic Lateral Sclerosis Survival, diabetes
Known Drugs/Compounds	metformin
Interactions	ACE2, Actin, AGING, AKT, ALOX15, ALZHEIMER
KG Connections	500 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: FGF21 — AlphaFold Q9NS73 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

FGF21 — Fibroblast Growth Factor 21

gene · 2052 words

→

Fibroblast Growth Factor 21 (FGF21)

biomarker · 1084 words

→

Pathway Diagram

flowchart TD
    FGF21["FGF21
Fibroblast Growth
Factor 21"]
    FGFR1["FGFR1
FGF Receptor 1"]
    JMJD3["JMJD3
Histone Demethylase"]
    
    LipidCat["Lipid Catabolism
Metabolic Process"]
    Inflammation["Inflammation
Immune Response"]
    Neuroinflam["Neuroinflammation
CNS Inflammation"]
    
    ALS["ALS
Amyotrophic Lateral
Sclerosis"]
    MS["Multiple Sclerosis
Demyelinating
Disease"]
    Stroke["Stroke
Cerebrovascular
Disease"]
    Ischemia["Ischemia
Reduced Blood Flow"]
    
    Aging["Aging
Cellular Senescence"]
    Senescence["Senescence
Age-related
Decline"]
    Fibrosis["Fibrosis
Tissue Scarring"]
    
    Diabetes["Diabetes
Metabolic
Dysfunction"]
    FattyLiver["Fatty Liver
Hepatic Steatosis"]
    
    FGF21 -->|"interacts with"| FGFR1
    FGF21 -->|"activates"| JMJD3
    FGF21 -->|"promotes"| LipidCat
    
    FGF21 -->|"biomarker for"| Inflammation
    FGF21 -->|"biomarker for"| ALS
    FGF21 -->|"biomarker for"| Aging
    FGF21 -->|"biomarker for"| Senescence
    
    FGF21 -->|"protects against"| Inflammation
    FGF21 -->|"protects against"| Neuroinflam
    FGF21 -->|"prevents"| FattyLiver
    
    FGF21 -->|"therapeutic target"| Stroke
    FGF21 -->|"therapeutic target"| MS
    FGF21 -->|"therapeutic target"| Fibrosis
    
    Inflammation -->|"leads to"| Neuroinflam
    Neuroinflam -->|"contributes to"| ALS
    Neuroinflam -->|"contributes to"| MS
    Ischemia -->|"triggers"| Stroke
    
    style FGF21 fill:#006494
    style FGFR1 fill:#4a1a6b
    style JMJD3 fill:#4a1a6b
    style LipidCat fill:#1b5e20
    style Inflammation fill:#ef5350
    style Neuroinflam fill:#ef5350
    style ALS fill:#5d4400
    style MS fill:#5d4400
    style Stroke fill:#5d4400
    style Aging fill:#ef5350
    style Fibrosis fill:#ef5350

Outgoing (359)

Target	Relation	Type	Str
Septic Liver Injury	associated_with	disease	0.95
Septic Liver Injury	treats	phenotype	0.95
Subarachnoid Hemorrhage	protects_against	disease	0.95
Inflammation	inhibits	process	0.95
Proinflammatory Macrophage Activation	inhibits	process	0.95
Hepatic Autophagy	activates	process	0.95
Neuroinflammation	associated_with	process	0.95
Parkinson's disease	protects_against	disease	0.92
Lipid Degradation	activates	process	0.92
cGAS-STING	inhibits	pathway	0.90
Autophagy	promotes	process	0.90
Mitophagy	associated_with	process	0.90
dopaminergic neuron survival	promotes	phenotype	0.89
PKA	activates	protein	0.88
microglia activation	modulates	process	0.88
mitochondrial homeostasis	promotes	process	0.87
STING	inhibits	protein	0.85
Hepatosteatosis	modulates	phenotype	0.85
Diabetes-Associated Cognitive Impairment	mediates	disease	0.85
Myogenesis	promotes	process	0.85
Amyotrophic Lateral Sclerosis Survival	associated_with	phenotype	0.85
Muscle Atrophy	expressed_in	phenotype	0.85
HIF-1α	modulates	protein	0.85
Non-alcoholic Fatty Liver Disease	treats	disease	0.85
Sepsis	treats	disease	0.85
Insulin Sensitivity	regulates	phenotype	0.85
CGAS	inhibits	protein	0.85
Non-Alcoholic Fatty Liver Disease	treats	disease	0.85
autophagy pathway	participates_in	pathway	0.80
dopaminergic neuron	stimulates_differentiation	cell_type	0.80
ACE2	interacts_with	gene	0.80
ERK1/2	activates	pathway	0.80
MITOPHAGY	promotes	process	0.80
Stress-Induced Cytotoxicity	inhibits	process	0.80
cGAS-STING pathway	inhibits	pathway	0.80
Parkinson's Disease	associated_with	disease	0.80
IL-6	activates	gene	0.80
Aging	therapeutic_target	disease	0.75
Inflammation	therapeutic_target	disease	0.75
Aging	activates	disease	0.75
Als	therapeutic_target	disease	0.75
Inflammation	activates	disease	0.75
SOD1	co_expressed_with	protein	0.75
Als	activates	disease	0.75
Aging	associated_with	process	0.75
Diabetes	activates	disease	0.75
JMJD3	activates	protein	0.72
hepatocellular carcinoma	protects_against	disease	0.70
pancreatic ductal adenocarcinoma	protects_against	disease	0.70
fatty liver	protects_against	disease	0.70

Incoming (142)

Source	Relation	Type	Str
Fasting	activates	process	0.90
Methionine Restriction	activates	process	0.90
Dietary Restriction	modulates	process	0.85
BCAA	associated_with	chemical	0.80
EXERCISE	activates	gene	0.80
AGING	therapeutic_target	gene	0.70
SIRT1	regulates	gene	0.70
BDNF	activates	gene	0.70
MTDNA	activates	gene	0.60
AGING	contributes_to	gene	0.60
ACE2	regulates	gene	0.60
ACE2	activates	gene	0.60
metformin	targets	drug	0.60
ULK1	activates	gene	0.60
CXCL10	activates	gene	0.60
PLAU	activates	gene	0.60
FGF23	activates	gene	0.60
APP	biomarker_for	gene	0.60
FGFR1	activates	gene	0.60
ATG7	activates	gene	0.60
COMPLEMENT	biomarker_for	gene	0.60
MTORC1	regulates	gene	0.60
APOPTOSIS	protects_against	gene	0.60
NOX4	activates	gene	0.60
PPAR	inhibits	gene	0.60
MTOR	regulates	gene	0.60
AKT	phosphorylates	gene	0.60
AGING	regulates	gene	0.60
NAD	regulates	gene	0.60
AUTOPHAGY	regulates	gene	0.60
NEUROINFLAMMATION	activates	gene	0.60
GLUT4	activates	gene	0.60
NEUROINFLAMMATION	inhibits	gene	0.60
DNA	activates	gene	0.60
APOPTOSIS	inhibits	gene	0.60
CGAS-STING	inhibits	gene	0.60
RNA	activates	gene	0.60
SOD1	activates	gene	0.60
SOD2	activates	gene	0.60
CGAS	activates	gene	0.60
ALOX15	regulates	gene	0.60
ALOX15	activates	gene	0.60
GENES	activates	gene	0.60
INSULIN RESISTANCE	implicated_in	gene	0.60
ALZHEIMER'S DISEASE	activates	gene	0.60
IGF-1	biomarker_for	gene	0.60
AGING	activates	gene	0.60
NEURODEGENERATION	activates	gene	0.60
INSULIN RESISTANCE	activates	gene	0.60
OXIDATIVE STRESS	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning FGF21 in their description or question text

No additional research found