gene

TNFAIP3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TNFAIP3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

86Connections

0Hypotheses

0Analyses

50Outgoing

32Incoming

0Experiments

0Debates

Summary

TNFAIP3 is a gene implicated in neurodegeneration research. Key relationships include: inhibits, associated with, regulates. Associated with Als, Inflammation, Ischemia. Connected to 38 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	TNFAIP3
Full Name	TNF Alpha Induced Protein 3 (A20)
Chromosome	6q23.3
Function	The NF-κB pathway controls the expression of inflammatory cytokines, chemokines, and survival genes.
Primary Expression	microglia, astrocytes, and neurons, where it controls neur
Molecular Weight	90 kDa
Amino Acids	790 aa
Exons	9
Pathways	NF-κB, NF-κB signaling
UniProt ID	[P21579](https://www.uniprot.org/uniprot/P21579)
Ensembl ID	ENSG00000118503
OMIM	191163
GeneCards	TNFAIP3
Human Protein Atlas	TNFAIP3
Deubiquitinase (DUB) activity	Removes ubiquitin chains from signaling molecules (TRAF6, RIPK1, NEMO)
Associated Diseases	Als, Ms
Interactions	ASTROCYTES, ATXN2, CGAS, CGAS-STING, Cytokine, CYTOKINES
KG Connections	86 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

TNFAIP3 — TNF Alpha Induced Protein 3 (A20)

gene · 2414 words

→

TNFAIP3 Protein

protein · 861 words

→

Pathway Diagram

graph TD
    TNFAIP3["TNFAIP3"]
    Als{"Als"}
    TNFAIP3 -->|"biomarker for"| Als
    Ms{"Ms"}
    TNFAIP3 -->|"biomarker for"| Ms
    Ischemia{"Ischemia"}
    TNFAIP3 -->|"biomarker for"| Ischemia
    TNFAIP3 -->|"associated with"| Als
    TNFAIP3 -->|"associated with"| Ms
    Inflammation{"Inflammation"}
    TNFAIP3 -->|"regulates"| Inflammation
    TNFAIP3 -->|"regulates"| Ischemia
    CEBPB["CEBPB"]
    TNFAIP3 -->|"associated with"| CEBPB
    IRF1["IRF1"]
    TNFAIP3 -->|"associated with"| IRF1
    Nf__b(["Nf-Kappab"])
    TNFAIP3 -->|"biomarker for"| Nf__b
    RIPK3["RIPK3"]
    TNFAIP3 -->|"regulates"| RIPK3
    Necroptosis(["Necroptosis"])
    TNFAIP3 -->|"associated with"| Necroptosis
    HSPA1B["HSPA1B"]
    HSPA1B -->|"associated with"| TNFAIP3
    SERPINE1["SERPINE1"]
    SERPINE1 -->|"associated with"| TNFAIP3
    NF__B["NF-KappaB"]
    NF__B -->|"biomarker for"| TNFAIP3
    HSPA1A["HSPA1A"]
    HSPA1A -->|"associated with"| TNFAIP3
    PYROPTOSIS["PYROPTOSIS"]
    PYROPTOSIS -->|"associated with"| TNFAIP3
    TMEM173["TMEM173"]
    TMEM173 -->|"regulates"| TNFAIP3
    STING1["STING1"]
    STING1 -->|"regulates"| TNFAIP3
    INFLAMMATION["INFLAMMATION"]
    INFLAMMATION -->|"regulates"| TNFAIP3
    IMMUNE_INFILTRATION["IMMUNE INFILTRATION"]
    IMMUNE_INFILTRATION -->|"associated with"| TNFAIP3
    style TNFAIP3 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (54)

Target	Relation	Type	Str
oxidative stress response	participates_in	pathway	0.70
Inflammation	regulates	disease	0.65
Als	biomarker_for	disease	0.65
Ms	biomarker_for	disease	0.65
Ischemia	biomarker_for	disease	0.65
Als	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Ischemia	regulates	disease	0.65
Inflammation	activates	disease	0.65
Neuroinflammation	activates	disease	0.65
Als	inhibits	disease	0.65
Inflammation	inhibits	disease	0.65
Inflammasome	inhibits	pathway	0.60
ASTROCYTES	activates	gene	0.60
IL-6	activates	gene	0.60
MICROGLIA	activates	gene	0.60
CYTOKINES	activates	gene	0.60
Microglia	activates	cell_type	0.60
Astrocyte	activates	cell_type	0.60
Cytokine	activates	protein	0.60
PI3K-AKT-mTOR signaling	participates_in	pathway	0.60
UBQLN2	interacts_with	gene	0.60
necroptosis	participates_in	pathway	0.60
PYROPTOSIS	inhibits	gene	0.60
Pyroptosis	inhibits	pathway	0.60
TNF	activates	gene	0.60
TRAF6	activates	gene	0.60
TRIM25	activates	gene	0.60
CGAS	inhibits	gene	0.60
STING	inhibits	gene	0.60
UBIQUITIN	inhibits	gene	0.60
GFAP	activates	gene	0.60
Nf-Κb	biomarker_for	pathway	0.60
NF-kB signaling	participates_in	pathway	0.60
CEBPB	associated_with	gene	0.60
ALS	interacts_with	disease	0.60
Necroptosis	associated_with	pathway	0.60
Pyroptosis	associated_with	pathway	0.60
SELF-DNA	activates	gene	0.60
INFLAMMATION	inhibits	gene	0.60
DNA	activates	gene	0.60
CGAS-STING	inhibits	gene	0.60
DSDNA	inhibits	gene	0.60
INOS	activates	gene	0.60
IRF1	associated_with	gene	0.60
RIPK3	regulates	gene	0.60
NEK7	inhibits	gene	0.60
NLRP3	inhibits	gene	0.60
HSPA1B	associated_with	gene	0.60
HSPA1A	associated_with	gene	0.60

Incoming (32)

Source	Relation	Type	Str
NF-ΚB	biomarker_for	gene	0.60
PYROPTOSIS	associated_with	gene	0.60
INFLAMMATION	regulates	gene	0.60
IMMUNE INFILTRATION	associated_with	gene	0.60
NEUROINFLAMMATION	activates	gene	0.60
CYTOKINES	activates	gene	0.60
IL-6	activates	gene	0.60
HSPA1B	associated_with	gene	0.60
SERPINE1	associated_with	gene	0.60
HSPA1A	associated_with	gene	0.60
CEBPB	associated_with	gene	0.60
PERK	activates	gene	0.60
PI3K	activates	gene	0.60
PTEN	activates	gene	0.60
RIPK1	activates	gene	0.60
GENES	associated_with	gene	0.60
ATXN2	interacts_with	gene	0.60
OPTN	interacts_with	gene	0.60
SQSTM1	interacts_with	gene	0.60
TAX1BP1	interacts_with	gene	0.60
TBK1	interacts_with	gene	0.60
INOS	activates	gene	0.60
MICROGLIA	activates	gene	0.60
ASTROCYTES	activates	gene	0.60
TMEM173	regulates	gene	0.60
STING1	regulates	gene	0.60
TNF	activates	gene	0.60
GFAP	activates	gene	0.60
PKA	activates	gene	0.60
RNA	activates	gene	0.60
ROS	activates	gene	0.60
TLR	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning TNFAIP3 in their description or question text

No additional research found