gene

CYP3A4

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CYP3A4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

298Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

2Debates

Summary

CYP3A4 is a gene implicated in neurodegeneration research. Key relationships include: associated with, activates, regulates. Associated with ALS, Als, Alzheimer. Connected to 175 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	CYP3A4
Full Name	Cytochrome P450 3A4
Chromosome	7q21.1
Function	CYP3A4 encodes cytochrome P450 3A4, which plays a critical role in
Primary Expression	the liver and intestinal mucosa
Pathways	Oxidative Stress
UniProt ID	[P08684](https://www.uniprot.org/uniprot/P08684)
Ensembl ID	ENSG00000123338
OMIM	171696
GeneCards	CYP3A4
Human Protein Atlas	CYP3A4
Associated Diseases	Als, Alzheimer, Alzheimer's disease, Anxiety
Known Drugs/Compounds	anxiolytic drugs
Interactions	ABCB1, AKT, ALZHEIMER, ALZHEIMER'S DISEASE, BID, CCL2
KG Connections	298 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

CYP3A4 — Cytochrome P450 3A4

gene · 711 words

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Pathway Diagram

flowchart TD
    CYP3A4["CYP3A4
Cytochrome P450
Drug Metabolizing Enzyme"]
    
    MTOR["mTOR
Mechanistic Target
of Rapamycin"]
    JUN["c-JUN
Transcription
Factor"]
    SNCA["SNCA
alpha-Synuclein
Protein"]
    
    ABCB1["ABCB1
P-glycoprotein
Drug Efflux Pump"]
    ABCG2["ABCG2
BCRP Transporter
Drug Efflux"]
    SLC6A2["SLC6A2
Norepinephrine
Transporter"]
    SLC6A3["SLC6A3
Dopamine
Transporter"]
    
    Epigenetic["Epigenetic
Regulation
Pathway"]
    
    Alzheimer["Alzheimer's
Disease"]
    Parkinson["Parkinson's
Disease"]
    ALS["ALS
Motor Neuron
Disease"]
    Dementia["Dementia
Cognitive Decline"]
    Depression["Depression
Mood Disorder"]
    MS["Multiple
Sclerosis"]
    
    Drug_Metabolism["Drug Metabolism
 and Clearance"]
    BBB_Transport["Blood-Brain Barrier
Drug Transport"]
    
    CYP3A4 -->|"regulates"| MTOR
    CYP3A4 -->|"activates"| JUN
    CYP3A4 -->|"metabolizes"| Drug_Metabolism
    CYP3A4 -->|"coordinates with"| ABCB1
    CYP3A4 -->|"coordinates with"| ABCG2
    
    MTOR -->|"influences"| Alzheimer
    JUN -->|"promotes"| Parkinson
    SNCA -->|"associated with"| Parkinson
    
    Drug_Metabolism -->|"affects"| BBB_Transport
    ABCB1 -->|"controls"| BBB_Transport
    ABCG2 -->|"controls"| BBB_Transport
    SLC6A2 -->|"regulates"| Depression
    SLC6A3 -->|"regulates"| Parkinson
    
    BBB_Transport -->|"therapeutic efficacy"| Dementia
    Epigenetic -->|"modulates"| CYP3A4
    
    CYP3A4 -->|"dual role"| ALS
    CYP3A4 -->|"associated with"| MS
    
    style CYP3A4 fill:#006494
    style MTOR fill:#4a1a6b
    style JUN fill:#4a1a6b
    style ABCB1 fill:#4a1a6b
    style ABCG2 fill:#4a1a6b
    style Drug_Metabolism fill:#1b5e20
    style BBB_Transport fill:#1b5e20
    style Epigenetic fill:#1b5e20
    style Alzheimer fill:#5d4400
    style Parkinson fill:#5d4400
    style ALS fill:#5d4400
    style Dementia fill:#5d4400
    style Depression fill:#ef5350
    style MS fill:#ef5350

Outgoing (170)

Target	Relation	Type	Str
anxiolytic drugs	modulates	drug	0.80
clopidogrel resistance	contributes_to	phenotype	0.80
Ms	associated_with	disease	0.65
Dementia	associated_with	disease	0.65
ALS	activates	disease	0.65
Parkinson	activates	disease	0.65
Als	protects_against	disease	0.65
Parkinson	protects_against	disease	0.65
Alzheimer	associated_with	disease	0.65
Als	activates	disease	0.65
Depression	associated_with	disease	0.65
Diabetes	regulates	disease	0.65
Metabolic Syndrome	regulates	disease	0.65
Als	regulates	disease	0.65
Nafld	associated_with	disease	0.65
Inflammation	regulates	disease	0.65
Fatty Liver	regulates	disease	0.65
Type 2 Diabetes	regulates	disease	0.65
Insulin Resistance	regulates	disease	0.65
Als	associated_with	disease	0.65
Carcinoma	associated_with	disease	0.65
Cirrhosis	associated_with	disease	0.65
Cirrhosis	activates	disease	0.65
Carcinoma	activates	disease	0.65
Ms	expressed_in	disease	0.65
Anxiety	associated_with	disease	0.65
Dementia	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Cancer	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Carcinoma	therapeutic_target	disease	0.65
Vascular Dementia	therapeutic_target	disease	0.65
Frontotemporal Dementia	transports	disease	0.65
Dementia	transports	disease	0.65
ALS	transports	disease	0.65
Vascular Dementia	transports	disease	0.65
Alzheimer	transports	disease	0.65
Frontotemporal Dementia	therapeutic_target	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Dementia	interacts_with	disease	0.65
ALS	inhibits	disease	0.65
Alzheimer	inhibits	disease	0.65
MTOR	regulates	protein	0.64
HSPA8	activates	gene	0.60
ONCOGENES	activates	gene	0.60
CCL2	activates	gene	0.60
Macrophage	activates	cell_type	0.60
MMP9	therapeutic_target	gene	0.60
PPAR	regulates	gene	0.60
SLC22A1	regulates	gene	0.60

Incoming (128)

Source	Relation	Type	Str
Mi-891	downregulates	drug	0.90
PXR	activates	protein	0.85
CYP2E1	associated_with	gene	0.60
ALZHEIMER	associated_with	gene	0.60
CYP1A2	interacts_with	gene	0.60
DNA	interacts_with	gene	0.60
CYP2E1	regulates	gene	0.60
INSULIN RESISTANCE	regulates	gene	0.60
OXIDATIVE STRESS	regulates	gene	0.60
CYP1A2	therapeutic_target	gene	0.60
AND	associated_with	gene	0.60
CYP3A5	associated_with	gene	0.60
PER	therapeutic_target	gene	0.60
DEMENTIA	transports	gene	0.60
ALZHEIMER	transports	gene	0.60
POR	transports	gene	0.60
CYP3A5	transports	gene	0.60
NR1I2	transports	gene	0.60
ALZHEIMER'S DISEASE	transports	gene	0.60
CYP1A2	regulates	gene	0.60
CYP1A1	activates	gene	0.60
CYP1A2	activates	gene	0.60
SLC6A4	affects	gene	0.60
CYP2D6	associated_with	gene	0.60
CYP2C19	associated_with	gene	0.60
MAOB	associated_with	gene	0.60
GABRA1	associated_with	gene	0.60
CHAT	associated_with	gene	0.60
HMGCR	associated_with	gene	0.60
OPRM1	associated_with	gene	0.60
SLC30A8	associated_with	gene	0.60
COMT	associated_with	gene	0.60
NBEA	associated_with	gene	0.60
HTR2C	associated_with	gene	0.60
ADRA2A	associated_with	gene	0.60
BCHE	associated_with	gene	0.60
SLC6A2	associated_with	gene	0.60
SLC6A3	associated_with	gene	0.60
SLC6A4	associated_with	gene	0.60
GSTP1	associated_with	gene	0.60
DRD2	associated_with	gene	0.60
EGF	activates	gene	0.60
ABCG2	associated_with	gene	0.60
PDK1	activates	gene	0.60
ERCC3	activates	gene	0.60
PI3K	activates	gene	0.60
EGFR	activates	gene	0.60
MTOR	expressed_in	gene	0.60
GPNMB	transports	gene	0.60
NUCKS1	transports	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Does Alectinib truly bind C1q directly with high affinity, or is this an experim

molecular biology | 2026-04-17 | 10 hypotheses Top: 0.455

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (2)

Multi-agent debates referencing this entity

The fundamental premise remains unvalidated despite extensive mechanistic specul

closed · Rounds: 4 · Score: 1.00 · 2026-04-19

The fundamental premise remains unvalidated despite extensive mechanistic specul

closed · Rounds: 4 · Score: 0.50 · 2026-04-18

Related Research

Hypotheses and analyses mentioning CYP3A4 in their description or question text

No additional research found