gene 567 words KG: CEBPB
Contents

CEBPB Gene

🧬 Gene Info
Gene SymbolCEBPB
Protein TypeTranscription Factor
FunctionThey function as homo- or heterodimers and regulate gene expression through their leucine zipper DNA-binding domains.
Primary Expressionvarious tissues including brain, where it plays important roles in:
PathwaysInnate Immunity
UniProt IDP17676
Ensembl IDENSG00000172216
GeneCardsCEBPB
Human Protein AtlasCEBPB
Glial Cell FunctionRegulation of astrocyte and microglial activation
Inflammatory ResponseControl of pro-inflammatory cytokine expression
Metabolic RegulationModulation of glucose and lipid metabolism
Cell DifferentiationInvolvement in cellular differentiation programs
Associated DiseasesAls, Cancer, Carcinoma, Cirrhosis
InteractionsAKT, ALZHEIMER, ALZHEIMER'S DISEASE, AMPK, AND, ATG5
KG Connections211 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (11)

AMPK hypersensitivity in astrocytes creates enhanced mitocho
Score: 0.82
Transcriptional Autophagy-Lysosome Coupling
Score: 0.76
CYP46A1 Overexpression Gene Therapy
Score: 0.73
Metabolic Switch Targeting for A1→A2 Repolarization
Score: 0.73
TFAM overexpression creates mitochondrial donor-recipient gr
Score: 0.73
Perforant Path Presynaptic Terminal Protection Strategy
Score: 0.70
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
Metabolic Reprogramming via Microglial Glycolysis Inhibition
Score: 0.67
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
HSP90-Tau Disaggregation Complex Enhancement
Score: 0.57

Related Analyses (6)

Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Epigenetic reprogramming in aging neurons
neurodegeneration · archived

See Also (13)

ATP P2X3 Receptor Neurons
cell · KG edge: activates
AMPK (AMP-Activated Protein Kinase)
entity · KG edge: activates
Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: activates
ATG5 — Autophagy Related 5
gene · KG edge: activates
ATG7 Gene
gene · KG edge: activates

Knowledge Graph (12 edges)

EGF activates CEBPB
CYP3A4 activates CEBPB
PDK1 activates CEBPB
MTOR activates CEBPB
EGFR activates CEBPB
ERCC3 activates CEBPB
PI3K activates CEBPB
CEBPB activates AKT
AKT activates CEBPB
CEBPB associated_with CYP3A4

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