gene

ERCC3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ERCC3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

43Connections

0Hypotheses

0Analyses

29Outgoing

14Incoming

0Experiments

0Debates

Summary

ERCC3 is a gene implicated in neurodegeneration research. Key relationships include: activates, associated with, risk factor for. Associated with ALS, Als, Carcinoma. Connected to 35 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	ERCC3
Chromosome	19q13.32.
Protein Type	Gene
Function	is a DNA repair gene located on chromosome 19q13.
Primary Expression	all human tissues, including: - Brain: neurons, astrocytes, microglia, oligodendroc
Molecular Weight	89 kDa
Amino Acids	782 aa
Exons	17
Pathways	Akt, Mtor, PI3K-AKT-mTOR signaling, Pi3K
GeneCards	ERCC3
Human Protein Atlas	ERCC3
Transcription initiation	ERCC3's helicase activity unwinds DNA at the promoter region, allowing RNA polymerase II to initiate transcription of neuronal genes
DNA repair	TC-NER removes bulky DNA lesions (UV-induced pyrimidine dimers, chemical adducts) that would otherwise block transcription
Neuronal survival	Proper DNA repair maintains genomic integrity in post-mitotic neurons, which cannot undergo replication-based repair
Associated Diseases	Als, Carcinoma, Cirrhosis
Interactions	AKT, AND, CCL2, CEBPB, CHKA, CYP1A2
KG Connections	43 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

ERCC3 Gene

gene · 637 words

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Pathway Diagram

graph TD
    ERCC3["ERCC3"]
    Cirrhosis{"Cirrhosis"}
    ERCC3 -->|"activates"| Cirrhosis
    Carcinoma{"Carcinoma"}
    ERCC3 -->|"activates"| Carcinoma
    Ms{"Ms"}
    ERCC3 -->|"activates"| Ms
    Als{"Als"}
    ERCC3 -->|"activates"| Als
    ERCC3 -->|"associated with"| Als
    ERCC3 -->|"associated with"| Carcinoma
    ERCC3 -->|"associated with"| Cirrhosis
    ALS{"ALS"}
    ERCC3 -->|"activates"| ALS
    CEBPB["CEBPB"]
    ERCC3 -->|"activates"| CEBPB
    Pi3K(["Pi3K"])
    ERCC3 -->|"activates"| Pi3K
    Mtor(["Mtor"])
    ERCC3 -->|"activates"| Mtor
    Akt(["Akt"])
    ERCC3 -->|"activates"| Akt
    EGF["EGF"]
    EGF -->|"activates"| ERCC3
    CYP3A4["CYP3A4"]
    CYP3A4 -->|"activates"| ERCC3
    PDK1["PDK1"]
    PDK1 -->|"activates"| ERCC3
    MTOR["MTOR"]
    MTOR -->|"activates"| ERCC3
    EGFR["EGFR"]
    EGFR -->|"activates"| ERCC3
    CYP1A2["CYP1A2"]
    CYP1A2 -->|"activates"| ERCC3
    AKT["AKT"]
    AKT -->|"activates"| ERCC3
    CEBPB -->|"activates"| ERCC3
    PI3K["PI3K"]
    PI3K -->|"activates"| ERCC3
    CCL2["CCL2"]
    CCL2 -->|"activates"| ERCC3
    style ERCC3 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (29)

Target	Relation	Type	Str
Hepatocellular Carcinoma	risk_factor_for	disease	0.85
Hepatocellular Carcinoma	contributes_to	disease	0.80
Ms	activates	disease	0.65
Als	activates	disease	0.65
Cirrhosis	activates	disease	0.65
Carcinoma	activates	disease	0.65
Als	associated_with	disease	0.65
Carcinoma	associated_with	disease	0.65
Cirrhosis	associated_with	disease	0.65
ALS	activates	disease	0.65
PSEN2	associated_with	gene	0.60
CYP1A2	activates	gene	0.60
CEBPB	activates	gene	0.60
ONCOGENES	activates	gene	0.60
PI3K-AKT-mTOR signaling	participates_in	pathway	0.60
PI3K	activates	gene	0.60
EGFR	activates	gene	0.60
MTOR	activates	gene	0.60
CYP3A4	activates	gene	0.60
AKT	activates	gene	0.60
Pi3K	activates	pathway	0.60
Mtor	activates	pathway	0.60
Akt	activates	pathway	0.60
Mtor	associated_with	pathway	0.60
AND	activates	gene	0.60
PDK1	activates	gene	0.60
EGF	activates	gene	0.60
Macrophage	expressed_in	cell_type	0.55
NAFLD	activates	disease	0.50

Incoming (14)

Source	Relation	Type	Str
CHKA	activates	gene	0.60
CCL2	activates	gene	0.60
ONCOGENES	activates	gene	0.60
EGF	activates	gene	0.60
CYP3A4	activates	gene	0.60
PDK1	activates	gene	0.60
MTOR	activates	gene	0.60
EGFR	activates	gene	0.60
AKT	activates	gene	0.60
CEBPB	activates	gene	0.60
PI3K	activates	gene	0.60
CCND3	associated_with	gene	0.60
CYP1A2	activates	gene	0.60
Pi3K	activates	pathway	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning ERCC3 in their description or question text

No additional research found