gene

DUSP6

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DUSP6: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

31Connections

0Hypotheses

0Analyses

15Outgoing

16Incoming

0Experiments

0Debates

Summary

DUSP6 is a gene implicated in neurodegeneration research. Key relationships include: inhibits, regulates, activates. Associated with Aging, Als, Fibrosis. Connected to 32 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	DUSP6
Full Name	Dual Specificity Phosphatase 6 (MKP3)
Chromosome	12p13
Protein Type	Phosphatase
Function	is a dual-specificity phosphatase that specifically dephosphorylates and inactivates ERK1/2 (Extracellular Signal-Regulated Kinases 1 and 2).
Primary Expression	brain regions involved in learning and memory:
Subcellular Localization	The protein has a classic PTP (protein tyrosine phosphatase) fold with the HCX5R active site motif essential for catalyt
Amino Acids	367 aa
Pathways	MAPK
UniProt ID	[O43508](https://www.uniprot.org/uniprot/O43508)
Ensembl ID	ENSG00000139318
OMIM	601653
GeneCards	DUSP6
Human Protein Atlas	DUSP6
ERK5	Minor substrate
Associated Diseases	neurodegeneration
Interactions	ASTROCYTES, DRP1, DUSP1, ERK1, ERK2, LRRK2
KG Connections	31 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

DUSP6 — Dual Specificity Phosphatase 6 (MKP3)

gene · 1259 words

→

MAP Kinase Phosphatase 3 (DUSP6/MKP3)

protein · 1196 words

→

Pathway Diagram

graph TD
    DUSP6["DUSP6"]
    Parkinson{"Parkinson"}
    DUSP6 -->|"inhibits"| Parkinson
    Ms{"Ms"}
    DUSP6 -->|"inhibits"| Ms
    Fibrosis{"Fibrosis"}
    DUSP6 -->|"therapeutic target"| Fibrosis
    Als{"Als"}
    DUSP6 -->|"regulates"| Als
    Aging{"Aging"}
    DUSP6 -->|"therapeutic target"| Aging
    DUSP6 -->|"activates"| Als
    DRP1["DRP1"]
    DUSP6 -->|"inhibits"| DRP1
    LRRK2["LRRK2"]
    DUSP6 -->|"inhibits"| LRRK2
    BMI1["BMI1"]
    DUSP6 -->|"regulates"| BMI1
    CEBPB["CEBPB"]
    DUSP6 -->|"regulates"| CEBPB
    Tgf__(["Tgf-Beta"])
    DUSP6 -->|"therapeutic target"| Tgf__
    ERK1["ERK1"]
    DUSP6 -->|"activates"| ERK1
    STX17["STX17"]
    STX17 -->|"inhibits"| DUSP6
    LRRK2 -->|"inhibits"| DUSP6
    PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
    PARKINSON_S_DISEASE -->|"inhibits"| DUSP6
    DRP1 -->|"inhibits"| DUSP6
    ASTROCYTES["ASTROCYTES"]
    ASTROCYTES -->|"inhibits"| DUSP6
    AGING["AGING"]
    AGING -->|"therapeutic target"| DUSP6
    FOS["FOS"]
    FOS -->|"regulates"| DUSP6
    HK2["HK2"]
    HK2 -->|"therapeutic target"| DUSP6
    LGALS3["LGALS3"]
    LGALS3 -->|"regulates"| DUSP6
    RELA["RELA"]
    RELA -->|"regulates"| DUSP6
    SOD2["SOD2"]
    SOD2 -->|"regulates"| DUSP6
    FGF21["FGF21"]
    FGF21 -->|"regulates"| DUSP6
    style DUSP6 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (15)

Target	Relation	Type	Str
Parkinson	inhibits	disease	0.65
Ms	inhibits	disease	0.65
Als	activates	disease	0.65
Fibrosis	therapeutic_target	disease	0.65
Als	regulates	disease	0.65
Aging	therapeutic_target	disease	0.65
Tgf-Β	therapeutic_target	pathway	0.60
Mapk	activates	pathway	0.60
BMI1	regulates	gene	0.60
CEBPB	regulates	gene	0.60
DRP1	inhibits	gene	0.60
ERK2	activates	gene	0.60
MIRO1	activates	gene	0.60
ERK1	activates	gene	0.60
LRRK2	inhibits	gene	0.60

Incoming (16)

Source	Relation	Type	Str
PARKINSON'S DISEASE	inhibits	gene	0.60
ASTROCYTES	inhibits	gene	0.60
STX17	inhibits	gene	0.60
LRRK2	inhibits	gene	0.60
MAPK3	activates	gene	0.60
MAPK1	activates	gene	0.60
MYC	expressed_in	gene	0.60
DUSP1	activates	gene	0.60
AGING	therapeutic_target	gene	0.60
DRP1	inhibits	gene	0.60
FOS	regulates	gene	0.60
HK2	therapeutic_target	gene	0.60
LGALS3	regulates	gene	0.60
RELA	regulates	gene	0.60
SOD2	regulates	gene	0.60
FGF21	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning DUSP6 in their description or question text

No additional research found