Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CYP1A2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
CYP1A2 is a concept in neurodegeneration research. Key relationships include: associated with, activates, therapeutic target. Associated with ALS, Als, Alzheimer. Connected to 118 entities in the SciDEX knowledge graph.
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| Name | CYP1A2 |
| Key Genes/Proteins | AADC, ABCB1, ABCG2, Actin, ADRA2A, ADRB2 |
| Related Diseases | Als, ALS, Alzheimer, Alzheimer's disease |
| Related Pathways | Akt |
graph TD
CYP1A2["CYP1A2"]
CYP1A2 -->|"target for"| Dementia["Dementia"]
CYP1A2 -->|"activates"| Carcinoma["Carcinoma"]
CYP1A2 -->|"activates"| Als["Als"]
CYP1A2 -->|"activates"| Cirrhosis["Cirrhosis"]
CYP1A2 -->|"expressed in"| Ms["Ms"]
CYP1A2 -->|"target for"| Cancer["Cancer"]
PDK1["PDK1"] -->|"activates"| CYP1A2
EGF["EGF"] -->|"activates"| CYP1A2
CYP3A4["CYP3A4"] -->|"interacts"| CYP1A2
CANCER["CANCER"] -->|"target for"| CYP1A2
OXIDATIVE_STRESS["OXIDATIVE STRESS"] -->|"target for"| CYP1A2
ABCB1["ABCB1"] -->|"interacts"| CYP1A2
PER["PER"] -->|"interacts"| CYP1A2
PI3K["PI3K"] -->|"activates"| CYP1A2
MTOR["MTOR"] -->|"expressed in"| CYP1A2
AKT["AKT"] -->|"activates"| CYP1A2| Target | Relation | Type | Str |
|---|---|---|---|
| anxiety | associated_with | disease | 0.80 |
| depression | associated_with | disease | 0.80 |
| GENES | therapeutic_target | gene | 0.70 |
| Anxiety | associated_with | disease | 0.65 |
| Dementia | associated_with | disease | 0.65 |
| Alzheimer | associated_with | disease | 0.65 |
| Depression | associated_with | disease | 0.65 |
| Dementia | therapeutic_target | disease | 0.65 |
| Als | associated_with | disease | 0.65 |
| Cirrhosis | associated_with | disease | 0.65 |
| Carcinoma | associated_with | disease | 0.65 |
| Carcinoma | therapeutic_target | disease | 0.65 |
| Als | therapeutic_target | disease | 0.65 |
| Ms | therapeutic_target | disease | 0.65 |
| Cancer | therapeutic_target | disease | 0.65 |
| Carcinoma | activates | disease | 0.65 |
| Dementia | interacts_with | disease | 0.65 |
| Als | activates | disease | 0.65 |
| Cirrhosis | activates | disease | 0.65 |
| Ms | expressed_in | disease | 0.65 |
| ALS | activates | disease | 0.65 |
| MTOR | regulates | protein | 0.64 |
| CYP3A4 | therapeutic_target | gene | 0.60 |
| PTGS2 | therapeutic_target | gene | 0.60 |
| MMP9 | therapeutic_target | gene | 0.60 |
| AADC | regulates | gene | 0.60 |
| Alzheimer's disease | associated_with | disease | 0.60 |
| autophagy pathway | participates_in | pathway | 0.60 |
| CYP2C19 | associated_with | gene | 0.60 |
| MTHFR | associated_with | gene | 0.60 |
| Oxidative Stress | therapeutic_target | pathway | 0.60 |
| DNA | interacts_with | gene | 0.60 |
| CYP3A4 | interacts_with | gene | 0.60 |
| Complement | activates | pathway | 0.60 |
| CCL2 | activates | gene | 0.60 |
| Macrophage | activates | cell_type | 0.60 |
| CYP3A4 | regulates | gene | 0.60 |
| ONCOGENES | activates | gene | 0.60 |
| AND | expressed_in | gene | 0.60 |
| Rb | regulates | protein | 0.60 |
| AKT | activates | gene | 0.60 |
| Pi3K | activates | pathway | 0.60 |
| Akt | activates | pathway | 0.60 |
| Mtor | expressed_in | pathway | 0.60 |
| BCHE | associated_with | gene | 0.60 |
| ALZHEIMER'S DISEASE | associated_with | gene | 0.60 |
| ANXIETY | associated_with | gene | 0.60 |
| ADRA2A | associated_with | gene | 0.60 |
| GENES | interacts_with | gene | 0.60 |
| ABCB1 | associated_with | gene | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| BCHE | associated_with | gene | 0.60 |
| ADRA2A | associated_with | gene | 0.60 |
| ADRB2 | associated_with | gene | 0.60 |
| GSTP1 | associated_with | gene | 0.60 |
| ABCB1 | associated_with | gene | 0.60 |
| AKT | associated_with | gene | 0.60 |
| CEBPB | associated_with | gene | 0.60 |
| CYP3A5 | associated_with | gene | 0.60 |
| PER | therapeutic_target | gene | 0.60 |
| CYP3A4 | interacts_with | gene | 0.60 |
| CANCER | therapeutic_target | gene | 0.60 |
| OXIDATIVE STRESS | therapeutic_target | gene | 0.60 |
| ABCB1 | interacts_with | gene | 0.60 |
| GABRA1 | associated_with | gene | 0.60 |
| DEPRESSION | associated_with | gene | 0.60 |
| SLC30A8 | associated_with | gene | 0.60 |
| SLC6A3 | associated_with | gene | 0.60 |
| APOE | associated_with | gene | 0.60 |
| PER | interacts_with | gene | 0.60 |
| NBEA | associated_with | gene | 0.60 |
| CYP2E1 | associated_with | gene | 0.60 |
| HTR2C | associated_with | gene | 0.60 |
| ALZHEIMER | associated_with | gene | 0.60 |
| CHAT | associated_with | gene | 0.60 |
| CYP2D6 | associated_with | gene | 0.60 |
| CYP3A4 | associated_with | gene | 0.60 |
| OPRM1 | associated_with | gene | 0.60 |
| PI3K | activates | gene | 0.60 |
| MTOR | expressed_in | gene | 0.60 |
| AKT | activates | gene | 0.60 |
| EGFR | activates | gene | 0.60 |
| CEBPB | activates | gene | 0.60 |
| CCL2 | activates | gene | 0.60 |
| ERCC3 | activates | gene | 0.60 |
| ANXIETY | associated_with | gene | 0.60 |
| HMGCR | associated_with | gene | 0.60 |
| SLC6A2 | associated_with | gene | 0.60 |
| SLC6A4 | associated_with | gene | 0.60 |
| COMT | associated_with | gene | 0.60 |
| ABCG2 | associated_with | gene | 0.60 |
| ALZHEIMER'S DISEASE | associated_with | gene | 0.60 |
| GENES | interacts_with | gene | 0.60 |
| CYP3A4 | expressed_in | gene | 0.60 |
| ONCOGENES | activates | gene | 0.60 |
| AND | expressed_in | gene | 0.60 |
| AADC | regulates | gene | 0.60 |
| MAO | regulates | gene | 0.60 |
| ROS | regulates | gene | 0.60 |
| MAO-B | regulates | gene | 0.60 |
| CYP1A1 | activates | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning CYP1A2 in their description or question text
No additional research found