Contents

APC Gene

🧬 Gene Info

Gene Symbol	APC
Chromosome	5q22.2
Protein Type	Gene
Function	is a tumor suppressor gene originally identified for its role in colorectal cancer, but increasingly recognized for its critical functions in the central nervous system.
Amino Acids	843 aa
Pathways	Akt, Autophagy, Epigenetic, Mapk, Mtor
UniProt ID	P25054
NCBI Gene ID	324
Ensembl ID	ENSG00000134982
GeneCards	APC
Human Protein Atlas	APC
Oligomerization domain (N-terminus)	Allows APC to form homodimers and heterodimers, essential for its scaffold function.
Armadillo repeats	Mediate interactions with beta-catenin, B-catenin, and other proteins containing armadillo repeat domains.
15-amino acid repeats	Bind to beta-catenin with varying affinities. The SAMP repeats mediate beta-catenin degradation.
Basic domain	Binds to microtubules and regulates cytoskeletal dynamics.
Associated Diseases	Aging, Als, Cancer, Carcinoma, Colorectal Cancer, Tumor
Known Drugs/Compounds	rapamycin
Interactions	ADNP, AKT, AKT1, AKT1S1, AND, APOPTOSIS
KG Connections	603 knowledge graph edges
Databases	GeneCards HPA STRING

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