gene

PARK7

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PARK7: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

610Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

PARK7 is a gene implicated in neurodegeneration research. Key relationships include: associated with, contributes to, interacts with. Associated with AD, ALS, Aging. Connected to 157 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	PARK7
Full Name	Parkinsonism Associated Deglycase (DJ-1)
Aliases	Page for PARK7 Gene
Chromosome	1p36.23
Protein Type	Protein
Function	DJ-1 has multiple cellular functions
Primary Expression	High in brain (substantia nigra), testis, kidney
Subcellular Localization	Cytoplasm, nucleus, mitochondria
Molecular Weight	20 kDa
Amino Acids	189 aa
Pathways	Alpha-Synuclein, Autophagy, Epigenetic, Er Stress, Inflammasome
UniProt ID	Q99497
GeneCards	PARK7
Human Protein Atlas	PARK7
Associated Diseases	AD, Als, Alzheimer, Alzheimer's disease, Amyotrophic Lateral Sclerosis
Interactions	ACETYL-COA, AD, AGING, AKT, Alpha-Synuclein, ALS
KG Connections	610 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: PARK7 — AlphaFold Q99497 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (12)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    PARK7["PARK7"]
    PARK7 -->|"causes"| PD["PD"]
    PARK7 -->|"regulates"| Neurodegeneration["Neurodegeneration"]
    PARK7 -.biomarker for.-> Alzheimer["Alzheimer"]
    PARK7 -.biomarker for.-> Ms["Ms"]
    PARK7 -.biomarker for.-> Als["Als"]
    PARK7 -->|"contributes to"| Parkinson["Parkinson"]
    PARK7 -->|"interacts"| Aging["Aging"]
    SOD1["SOD1"] -->|"regulates"| PARK7
    VPS35["VPS35"] -->|"contributes to"| PARK7
    LRRK2["LRRK2"] -->|"contributes to"| PARK7
    GBA1["GBA1"] -->|"contributes to"| PARK7
    GENES["GENES"] -->|"contributes to"| PARK7
    DNA["DNA"] -->|"target for"| PARK7
    PINK1["PINK1"] -->|"contributes to"| PARK7
    PRKN["PRKN"] -->|"contributes to"| PARK7
    DNM1L["DNM1L"] -.biomarker for.-> PARK7
    FIS1["FIS1"] -.biomarker for.-> PARK7

Outgoing (321)

Target	Relation	Type	Str
Parkinson's Disease	causes	disease	0.95
Parkinson's Disease	associated_with	disease	0.95
Alzheimer's Disease	biomarker_for	disease	0.85
Neurodegeneration	associated_with	process	0.85
oxidative stress	suppresses	process	0.85
neurodegeneration	associated_with	phenotype	0.85
proteostasis	regulates	process	0.85
Als	associated_with	disease	0.75
PD	causes	disease	0.72
SIRT1	activates	gene	0.70
SOD1	activates	gene	0.70
SYNJ1	associated_with	gene	0.70
PINK1	protects_against	gene	0.70
STING	associated_with	gene	0.70
TRAF6	activates	gene	0.70
TNF	activates	gene	0.70
TFEB	activates	gene	0.70
SQSTM1	activates	gene	0.70
ULK1	activates	gene	0.70
GENES	associated_with	gene	0.70
SNCA	associated_with	gene	0.70
PRKN	associated_with	gene	0.70
stem cells	expressed_in	cell_type	0.70
oxidative stress response	participates_in	pathway	0.70
SYNJ1	interacts_with	gene	0.70
PRKN	interacts_with	gene	0.70
ALS	biomarker_for	disease	0.65
Alzheimer	biomarker_for	disease	0.65
Neurodegeneration	regulates	disease	0.65
Als	expressed_in	disease	0.65
Huntington	associated_with	disease	0.65
Parkinson	causes	disease	0.65
Huntington	expressed_in	disease	0.65
Als	biomarker_for	disease	0.65
Ms	causes	disease	0.65
LAMP2	causes	gene	0.65
Parkinson	associated_with	disease	0.65
Parkinson	expressed_in	disease	0.65
NRF2	regulates	gene	0.65
Ms	biomarker_for	disease	0.65
ALS	regulates	disease	0.65
PARKIN	interacts_with	gene	0.65
SNCA	interacts_with	gene	0.65
ALS	associated_with	disease	0.65
FERROPTOSIS	causes	phenotype	0.65
ROS	activates	phenotype	0.65
ROS	regulates	phenotype	0.65
apoptosis	co_discussed	concept	0.65
Alzheimer	interacts_with	disease	0.65
Aging	interacts_with	disease	0.65

Incoming (289)

Source	Relation	Type	Str
BECN1	associated_with	gene	0.70
ATP13A2	causes	gene	0.70
NEP	associated_with	gene	0.70
NRF2	activates	gene	0.70
NFKB	activates	gene	0.70
KEAP1	activates	gene	0.70
BECN1	activates	gene	0.70
AMPK	activates	gene	0.70
APP	activates	gene	0.70
NEURONS	activates	cell_type	0.70
NLRP3	associated_with	gene	0.70
NRF2	associated_with	gene	0.70
MACROPHAGE	activates	cell_type	0.70
LRRK2	protects_against	gene	0.70
LRRK2	activates	gene	0.70
GBA	activates	gene	0.70
ENDOTHELIAL	activates	cell_type	0.70
DOPAMINERGIC	associated_with	cell_type	0.70
FBXO7	interacts_with	gene	0.70
GBA1	interacts_with	gene	0.70
ALZHEIMER	associated_with	gene	0.70
DNAJC6	interacts_with	gene	0.70
LRRK2	associated_with	gene	0.70
ATP13A2	interacts_with	gene	0.70
NRF2	co_discussed	gene	0.65
AUTOPHAGY	associated_with	gene	0.65
FBXO7	co_discussed	gene	0.65
MTOR	interacts_with	gene	0.65
ATP13A2	associated_with	gene	0.65
LRRK2	co_discussed	gene	0.60
LRRK2	interacts_with	gene	0.60
GBA	interacts_with	gene	0.60
PARKINSON'S DISEASE	associated_with	gene	0.60
CHCHD10	interacts_with	gene	0.60
FUS	interacts_with	gene	0.60
DJ-1	expressed_in	protein	0.60
DJ-1	regulates	gene	0.60
PARKINSON	regulates	gene	0.60
OXIDATIVE STRESS	regulates	gene	0.60
HIF	regulates	gene	0.60
ALZHEIMER	regulates	gene	0.60
ALS	expressed_in	gene	0.60
PARK1	causes	gene	0.60
SAMHD1	associated_with	gene	0.60
GBA1	causes	gene	0.60
LRRK2	causes	gene	0.60
APP	co_discussed	gene	0.60
ATP13A2	co_discussed	gene	0.60
HSP90	associated_with	gene	0.60
HSP70	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PARK7 in their description or question text

No additional research found

PARK7

Understanding Entity Pages

Summary

Wiki Pages (12)

PARK7 — Parkinsonism Associated Deglycase (DJ-1)

PARK7 (DJ-1) Targeted Therapy for Parkinson's Disease

DJ-1/PARK7 Neuroprotection Pathway in Parkinson's Disease

PARK7/DJ-1 Neuroprotection Pathway — Parkinson's Disease Causal Chain

PARK7 — Parkinsonism Associated Deglycase (DJ-1)

DJ-1 Protein (PARK7)

GPR37 (PARK7) Neurons

PARK7 Gene - DJ-1/PARK7

DJ1 (PARK7)

DJ-1 (PARK7) Neuroprotective Therapies

PARK7 (DJ-1) Protein

PARK7 Protein (DJ-1)