gene

ATP5F1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ATP5F1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

20Connections

0Hypotheses

0Analyses

16Outgoing

4Incoming

0Experiments

0Debates

Summary

ATP5F1 is a gene implicated in neurodegeneration research. Key relationships include: interacts with, implicated in. Associated with Aging, Als, Alzheimer. Connected to 21 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	ATP5F1
Full Name	ATP Synthase F1 Subunit Beta
Chromosome	1p13.3
Function	encodes the beta subunit of the F1 catalytic sector of mitochondrial ATP synthase, also known as Complex V of the electron transport chain[@nature2010]
Primary Expression	Brain, Heart, Muscle
Amino Acids	511 aa
UniProt ID	P06576
NCBI Gene ID	547
Ensembl ID	ENSG00000067715
GeneCards	ATP5F1
Human Protein Atlas	ATP5F1
Interactions	ACETYL-COA, AGING, AMPK, BACE1, CLOCK, HUNTINGTON'S DISEASE
KG Connections	20 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: ATP5F1 — AlphaFold P06576 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

ATP5F1 — ATP Synthase F1 Subunit Beta

gene · 4040 words

→

ATP5F1 Protein — ATP Synthase F1 Subunit Beta

protein · 556 words

→

Pathway Diagram

graph TD
    ATP5F1["ATP5F1"]
    Alzheimer{"Alzheimer"}
    ATP5F1 -->|"interacts with"| Alzheimer
    Aging{"Aging"}
    ATP5F1 -->|"interacts with"| Aging
    Als{"Als"}
    ATP5F1 -->|"interacts with"| Als
    Huntington{"Huntington"}
    ATP5F1 -->|"interacts with"| Huntington
    Parkinson{"Parkinson"}
    ATP5F1 -->|"interacts with"| Parkinson
    Ms{"Ms"}
    ATP5F1 -->|"interacts with"| Ms
    P53["P53"]
    ATP5F1 -->|"interacts with"| P53
    LMNA["LMNA"]
    ATP5F1 -->|"interacts with"| LMNA
    HUNTINGTON_S_DISEASE["HUNTINGTON'S DISEASE"]
    ATP5F1 -->|"interacts with"| HUNTINGTON_S_DISEASE
    CLOCK["CLOCK"]
    ATP5F1 -->|"interacts with"| CLOCK
    SDHB["SDHB"]
    ATP5F1 -->|"interacts with"| SDHB
    PPARG["PPARG"]
    ATP5F1 -->|"interacts with"| PPARG
    AGING["AGING"]
    AGING -->|"interacts with"| ATP5F1
    NEURODEGENERATIVE_DISEASES["NEURODEGENERATIVE DISEASES"]
    NEURODEGENERATIVE_DISEASES -->|"interacts with"| ATP5F1
    SIRT3["SIRT3"]
    SIRT3 -->|"interacts with"| ATP5F1
    PGC1A["PGC1A"]
    PGC1A -->|"interacts with"| ATP5F1
    style ATP5F1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (16)

Target	Relation	Type	Str
Ms	interacts_with	disease	0.65
Aging	interacts_with	disease	0.65
Als	interacts_with	disease	0.65
Huntington	interacts_with	disease	0.65
Parkinson	interacts_with	disease	0.65
Alzheimer	interacts_with	disease	0.65
HUNTINGTON'S DISEASE	interacts_with	gene	0.60
AMPK	interacts_with	gene	0.60
ACETYL-COA	interacts_with	gene	0.60
P53	interacts_with	gene	0.60
LMNA	interacts_with	gene	0.60
CLOCK	interacts_with	gene	0.60
SDHB	interacts_with	gene	0.60
PPARG	interacts_with	gene	0.60
PARK7	interacts_with	gene	0.60
BACE1	interacts_with	gene	0.60

Incoming (4)

Source	Relation	Type	Str
AGING	interacts_with	gene	0.60
NEURODEGENERATIVE DISEASES	interacts_with	gene	0.60
SIRT3	interacts_with	gene	0.60
PGC1A	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning ATP5F1 in their description or question text

No additional research found