concept

HUNTINGTON'S DISEASE

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HUNTINGTON'S DISEASE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1654Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

5Debates

Summary

HUNTINGTON'S DISEASE is a concept in neurodegeneration research. Key relationships include: associated with, activates, regulates. Associated with ALS, Aging, Als. Connected to 534 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	HUNTINGTON'S DISEASE
Key Genes/Proteins	AADC, ACETYL-COA, ACHE, AD, AGING, AIF
Related Diseases	adrenoleukodystrophy, aging, Aging, Als, Alzheimer

Pathway Diagram

graph TD
    HUNTINGTON_S_DISEASE["HUNTINGTON'S DISEASE"]
    HUNTINGTON_S_DISEASE -->|"causes"| NEURODEGENERATION["NEURODEGENERATION"]
    HUNTINGTON_S_DISEASE -->|"target for"| Als["Als"]
    HUNTINGTON_S_DISEASE -->|"target for"| Inflammation["Inflammation"]
    HUNTINGTON_S_DISEASE -->|"interacts"| Alzheimer["Alzheimer"]
    HUNTINGTON_S_DISEASE -->|"target for"| Neurodegeneration["Neurodegeneration"]
    HUNTINGTON_S_DISEASE -->|"interacts"| Multiple_Sclerosis["Multiple Sclerosis"]
    HUNTINGTON_S_DISEASE -->|"interacts"| Huntington["Huntington"]
    HUNTINGTON_S_DISEASE -->|"target for"| Neuroinflammation["Neuroinflammation"]
    HUNTINGTON_S_DISEASE -->|"target for"| Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
    HUNTINGTON_S_DISEASE -->|"target for"| Parkinson["Parkinson"]
    CAG_EXPANSION["CAG EXPANSION"] -->|"causes"| HUNTINGTON_S_DISEASE
    PPARGC1A["PPARGC1A"] -.protects against.-> HUNTINGTON_S_DISEASE
    DH1["DH1"] -->|"treats"| HUNTINGTON_S_DISEASE
    NRF2["NRF2"] -.protects against.-> HUNTINGTON_S_DISEASE
    huntingtin["huntingtin"] -->|"causes"| HUNTINGTON_S_DISEASE
    antisense_oligonucleotides["antisense oligonucleotides"] -->|"treats"| HUNTINGTON_S_DISEASE
    protein_misfolding["protein misfolding"] -->|"causes"| HUNTINGTON_S_DISEASE
    STAT3["STAT3"] -->|"regulates"| HUNTINGTON_S_DISEASE
    ginsenosides["ginsenosides"] -->|"treats"| HUNTINGTON_S_DISEASE
    NEAT1["NEAT1"] -.biomarker for.-> HUNTINGTON_S_DISEASE

Outgoing (790)

Target	Relation	Type	Str
AMYOTROPHIC LATERAL SCLEROSIS	associated_with	gene	1.00
Amyotrophic Lateral Sclerosis	associated_with	disease	1.00
ALZHEIMER'S DISEASE	associated_with	gene	1.00
Neurodegeneration	activates	disease	1.00
Alzheimer	associated_with	disease	1.00
Neurodegeneration	regulates	disease	1.00
Huntington	activates	disease	1.00
Parkinson	associated_with	disease	1.00
Huntington	causes	disease	1.00
Huntington	associated_with	disease	1.00
Parkinson	causes	disease	0.95
Als	activates	disease	0.95
Alzheimer	causes	disease	0.95
Circadian Rhythm	associated_with	process	0.95
Neurodegeneration	therapeutic_target	disease	0.95
NEURODEGENERATION	causes	gene	0.95
Als	therapeutic_target	disease	0.95
Neurodegeneration	associated_with	disease	0.95
Amyotrophic Lateral Sclerosis	causes	disease	0.95
Non-Coding Rna	therapeutic_target	compound	0.92
astrocytes	affects	cell_type	0.90
TDP-43 Nuclear Localization Disruption	causes	phenotype	0.90
neural stem cells	affects	cell_type	0.90
oxidative stress response	involves	pathway	0.90
striatum	affects	brain_region	0.90
cerebellum	affects	brain_region	0.90
neurons	affects	cell_type	0.90
AMYOTROPHIC LATERAL SCLEROSIS	causes	gene	0.90
ALZHEIMER'S DISEASE	causes	gene	0.90
Huntington	regulates	disease	0.85
Aging	activates	disease	0.85
m6A RNA Modification	downregulates	process	0.85
Alzheimer	activates	disease	0.85
Aging	associated_with	disease	0.85
Stroke	associated_with	disease	0.85
Multiple Sclerosis	associated_with	disease	0.85
Inflammation	regulates	disease	0.85
Als	associated_with	disease	0.85
mitochondrial function	involves	pathway	0.80
unfolded protein response	involves	pathway	0.80
autophagy pathway	involves	pathway	0.80
ferroptosis	involves	pathway	0.80
metabolic stress	associated_with	process	0.80
Mtor	activates	pathway	0.80
AGING	associated_with	gene	0.80
STROKE	associated_with	gene	0.80
AUTOPHAGY	activates	gene	0.80
Autophagy	activates	pathway	0.80
Apoptosis	therapeutic_target	pathway	0.80
Neuroinflammation	regulates	disease	0.75

Incoming (864)

Source	Relation	Type	Str
NEURODEGENERATION	associated_with	gene	1.00
ALS	associated_with	gene	1.00
AMYLOID	associated_with	protein	1.00
PARKINSON	associated_with	gene	1.00
ALZHEIMER	associated_with	gene	1.00
ALZHEIMER'S DISEASE	associated_with	gene	1.00
PARKINSON'S DISEASE	associated_with	gene	1.00
HUNTINGTON	activates	gene	1.00
NEURODEGENERATION	regulates	gene	1.00
HUNTINGTON	associated_with	gene	1.00
NEURODEGENERATIVE DISORDERS	part_of	gene	1.00
HUNTINGTON	causes	gene	1.00
NEURODEGENERATIVE DISEASES	therapeutic_target	gene	1.00
NEURODEGENERATIVE DISEASES	associated_with	gene	1.00
NEURODEGENERATIVE DISEASES	activates	gene	1.00
Circadian Clock	associated_with	process	0.95
HTT	causes	gene	0.95
CAG EXPANSION	causes	gene	0.95
Berbamine Hydrochloride	treats	drug	0.95
proteostasis depletion	contributes_to	process	0.90
38609352	causes	paper	0.90
GAL3	implicated_in	protein	0.90
protein aggregation	causes	process	0.90
TAU	associated_with	protein	0.90
39843658	causes	paper	0.90
39843658	drives	paper	0.90
Parthanatos	involved_in	pathway	0.90
Reactive astrogliosis	contributes_to	process	0.90
Parthanatos	involved_in	pathway	0.90
Purinergic Signaling	associated_with	pathway	0.90
Stau1	biomarker_for	biomarker	0.90
Circadian Disturbance	biomarker_for	phenotype	0.90
ASK1	associated_with	protein	0.90
ALS	associated_with	gene	0.90
NPY	implicated_in	protein	0.90
Neuroinflammation	contributes_to	process	0.90
36482283	is characterized by	paper	0.90
38609352	is a genetic modifier of	paper	0.90
MRI	associated_with	process	0.90
IGF2	associated_with	protein	0.90
HTT	causes	gene	0.90
NEURODEGENERATION	therapeutic_target	gene	0.90
NEURODEGENERATIVE DISEASES	regulates	gene	0.90
NEURODEGENERATIVE DISORDERS	associated_with	gene	0.90
ALZHEIMER	causes	gene	0.90
PARKINSON	causes	gene	0.90
PARKINSON'S DISEASE	causes	gene	0.90
RB5	treats	drug	0.87
Circadian Molecular Clockwork	contributes_to	mechanism	0.85
cGAS-STING	involved_in	pathway	0.85

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Lipid raft composition changes in synaptic neurodegeneration

neurodegeneration | 2026-04-01 | 13 hypotheses Top: 0.852

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (5)

Multi-agent debates referencing this entity

Related Research

Hypotheses and analyses mentioning HUNTINGTON'S DISEASE in their description or question text

No additional research found