concept

GFP

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GFP: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1015Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

GFP is a concept in neurodegeneration research. Key relationships include: associated with, activates, inhibits. Associated with AD, ALI, ALS. Connected to 429 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	GFP
Key Genes/Proteins	ABL1, ABP, ACETYL-COA, ACLY, ACTB, Actin
Related Diseases	AD, Aging, ALI, Als
Related Pathways	Akt

Pathway Diagram

graph TD
    GFP["GFP"]
    GFP -->|"expressed in"| microglia["microglia"]
    GFP -->|"interacts"| Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
    GFP -->|"interacts"| ALS["ALS"]
    GFP -->|"interacts"| Dementia["Dementia"]
    GFP -->|"activates"| Tumor["Tumor"]
    GFP -->|"degrades"| Aging["Aging"]
    GFP -->|"degrades"| Cardiovascular["Cardiovascular"]
    GFP -->|"inhibits"| Inflammation["Inflammation"]
    C9ORF72["C9ORF72"] -->|"interacts"| GFP
    LC3["LC3"] -->|"interacts"| GFP
    P62["P62"] -->|"interacts"| GFP
    FUS["FUS"] -->|"interacts"| GFP
    UBIQUITIN["UBIQUITIN"] -->|"interacts"| GFP
    SQSTM1["SQSTM1"] -->|"interacts"| GFP
    TRIM21["TRIM21"] -->|"interacts"| GFP
    OPTN["OPTN"] -->|"interacts"| GFP
    NEURODEGENERATIVE_DISEASES["NEURODEGENERATIVE DISEASES"] -->|"regulates"| GFP
    ACTB["ACTB"] -->|"interacts"| GFP

Outgoing (703)

Target	Relation	Type	Str
AUTOPHAGY	activates	gene	1.00
Autophagy	activates	pathway	1.00
Autophagy	associated_with	pathway	1.00
LC3	associated_with	gene	1.00
AUTOPHAGY	associated_with	gene	1.00
Mtor	activates	pathway	1.00
MTOR	activates	gene	1.00
Tumor	activates	disease	0.95
oxidative stress response	participates_in	pathway	0.90
autophagy pathway	participates_in	pathway	0.90
AKT	activates	gene	0.90
Als	activates	disease	0.85
Aging	inhibits	disease	0.85
Infection	activates	disease	0.85
MCOLN1	activates	gene	0.80
neurons	regulates	cell_type	0.80
neural stem cells	activates	cell_type	0.80
ubiquitin-proteasome	participates_in	pathway	0.80
apoptosis pathway	participates_in	pathway	0.80
AMPK	activates	gene	0.80
Apoptosis	associated_with	pathway	0.80
APOPTOSIS	activates	gene	0.80
Pi3K/Akt	activates	pathway	0.80
Mtor	associated_with	pathway	0.80
PI3K	activates	gene	0.80
LC3	activates	gene	0.80
Apoptosis	activates	pathway	0.80
Tumor	inhibits	disease	0.75
Als	associated_with	disease	0.75
Cancer	therapeutic_target	disease	0.75
Cancer	associated_with	disease	0.75
Inflammation	activates	disease	0.75
MCOLN1	interacts_with	gene	0.70
blood-brain barrier	participates_in	pathway	0.70
ATG	associated_with	gene	0.70
adenosine	activates	neurotransmitter	0.70
ATG5	activates	gene	0.70
neurons	disrupts	cell_type	0.70
DMSO	associated_with	gene	0.70
BCL-2	activates	gene	0.70
Autophagy	therapeutic_target	pathway	0.70
Apoptosis	therapeutic_target	pathway	0.70
CANCER	therapeutic_target	gene	0.70
UBIQUITIN	associated_with	gene	0.70
GENES	therapeutic_target	gene	0.70
APOPTOSIS	associated_with	gene	0.70
BECN1	associated_with	gene	0.70
Mtor	inhibits	pathway	0.70
MAP1LC3	activates	gene	0.70
MAP1LC3	associated_with	gene	0.70

Incoming (312)

Source	Relation	Type	Str
rapamycin	targets	drug	0.80
CTSD	interacts_with	gene	0.70
DNA	activates	gene	0.70
CTSB	activates	gene	0.70
SQSTM1	associated_with	gene	0.70
CTSD	activates	gene	0.70
BECN1	associated_with	gene	0.70
CALCOCO2	regulates	gene	0.70
AMPK	interacts_with	gene	0.70
CASP3	activates	gene	0.70
CTSB	interacts_with	gene	0.70
BECN1	activates	gene	0.70
GBM	regulates	gene	0.60
EPG5	regulates	gene	0.60
TSPAN1	regulates	gene	0.60
G3BP1	activates	gene	0.60
FUS	activates	gene	0.60
BECN1	interacts_with	gene	0.60
TAU	expressed_in	gene	0.60
FUS	regulates	gene	0.60
FAM83A	activates	gene	0.60
CALCOCO2	activates	gene	0.60
ATG7	interacts_with	gene	0.60
BCL2	interacts_with	gene	0.60
BCL2L13	interacts_with	gene	0.60
BNIP3L	interacts_with	gene	0.60
COX4I1	interacts_with	gene	0.60
GAPDH	interacts_with	gene	0.60
AIF1	regulates	gene	0.60
ASC	regulates	gene	0.60
ALZHEIMER	expressed_in	gene	0.60
CSNK1A1	activates	gene	0.60
SREBP1	activates	gene	0.60
ATG7	protects_against	gene	0.60
DHFR	associated_with	gene	0.60
EGF	interacts_with	gene	0.60
CCND1	activates	gene	0.60
EEA1	interacts_with	gene	0.60
DMSO	interacts_with	gene	0.60
CR1	biomarker_for	gene	0.60
CTNNB1	activates	gene	0.60
MICROGLIA	expressed_in	gene	0.60
ALS	regulates	gene	0.60
AXIN2	activates	gene	0.60
ALS	activates	gene	0.60
G3BP1	regulates	gene	0.60
GBM	interacts_with	gene	0.60
AMPK	regulates	gene	0.60
ATG	regulates	gene	0.60
GFAP	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning GFP in their description or question text

No additional research found