protein

VPS16

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about VPS16: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

25Connections

0Hypotheses

0Analyses

18Outgoing

7Incoming

0Experiments

0Debates

Summary

VPS16 is a protein involved in neurodegeneration research. Key relationships include: inhibits, participates in, interacts with. Associated with Als, colorectal cancer, dystonia. Connected to 14 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	VPS16
Full Name	Vacuolar Protein Sorting 16 Homolog
Chromosome	20q13.33
Function	In neurons, VPS16 and the HOPS complex play essential roles in
Molecular Weight	89 kDa
Amino Acids	790 aa
UniProt ID	Q9H269
NCBI Gene ID	64601
Ensembl ID	ENSG00000112357
GeneCards	VPS16
Human Protein Atlas	VPS16
Associated Diseases	colorectal cancer, dystonia
Interactions	AND, ATP, LC3, LYSOSOME, Ras, STX17
KG Connections	25 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: VPS16 — AlphaFold Q9H269 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

VPS16 Gene

gene · 918 words

→

VPS16 Protein

protein · 619 words

→

Pathway Diagram

graph TD
    VPS16["VPS16"]
    HOPS["HOPS"]
    VPS16 -->|"component of"| HOPS
    lysosome["lysosome"]
    VPS16 -->|"participates in"| lysosome
    dystonia{"dystonia"}
    VPS16 -->|"causes"| dystonia
    colorectal_cancer{"colorectal cancer"}
    VPS16 -->|"associated with"| colorectal_cancer
    CORVET["CORVET"]
    VPS16 -->|"component of"| CORVET
    endosome["endosome"]
    VPS16 -->|"participates in"| endosome
    autophagy["autophagy"]
    VPS16 -->|"regulates"| autophagy
    Als{"Als"}
    VPS16 -->|"interacts with"| Als
    LC3["LC3"]
    VPS16 -->|"inhibits"| LC3
    neurodegeneration["neurodegeneration"]
    VPS16 -->|"implicated in"| neurodegeneration
    VPS33A["VPS33A"]
    VPS33A -->|"binds"| VPS16
    VPS33A -->|"inhibits"| VPS16
    STX17["STX17"]
    STX17 -->|"inhibits"| VPS16
    UVRAG["UVRAG"]
    UVRAG -->|"interacts with"| VPS16
    style VPS16 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (18)

Target	Relation	Type	Str
lysosome	participates_in	entity	0.90
HOPS	component_of	entity	0.90
dystonia	causes	disease	0.90
colorectal cancer	associated_with	disease	0.80
CORVET	component_of	entity	0.80
endosome	participates_in	entity	0.80
Als	interacts_with	disease	0.65
ACSL5	associated_with	gene	0.60
Ras	activates	protein	0.60
VPS33A	inhibits	gene	0.60
ATP	activates	gene	0.60
STX17	inhibits	gene	0.60
COX15	associated_with	gene	0.60
RPL4	associated_with	gene	0.60
UVRAG	interacts_with	gene	0.60
LC3	inhibits	gene	0.60
AND	inhibits	gene	0.60
LYSOSOME	interacts_with	gene	0.60

Incoming (7)

Source	Relation	Type	Str
VPS33A	associated_with	protein	0.90
VPS33A	inhibits	gene	0.60
STX17	inhibits	gene	0.60
UVRAG	interacts_with	gene	0.60
PPP1R7	associated_with	gene	0.60
ABCB1	associated_with	gene	0.60
PEX3	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning VPS16 in their description or question text

No additional research found